Perfectionism and burnout in canoe polo and kayak slalom athletes: The mediating influence of validation and growth-seeking

Recent research suggests that validation-seeking and dimensions of perfectionism may be antecedents of athlete burnout. The present investigation examined whether validation and growth-seeking mediate the relationship between selforiented and socially prescribed perfectionism and burnout. One-hundred and fifty canoe polo and kayak slalom athletes recruited from the top two divisions in the UK completed measures of validation and growth-seeking (GOI), perfectionism (HMPS), and athlete burnout (ABQ). Analyses supported the mediating role of validation-seeking in the relationship between socially prescribed perfectionism and burnout. However, while bivariate correlations indicated that self-oriented perfectionism was positively related to both validation and growth-seeking, neither mediated the self-oriented perfectionism-burnout relationship. The findings suggest that validation-seeking may be an important psychological factor in the development of burnout for athletes exhibiting high levels of socially prescribed perfectionism. The relationship between self-oriented perfectionism and athlete burnout remains unclear because of its association with multiple motives and with socially prescribed perfectionism

A Three-Wave Longitudinal Test of Self-Determination Theory's Mediation Model of Engagement and Disaffection in Youth Sport.

Research adopting self-determination theory (SDT) supports a mediation model whereby coach motivational styles (autonomy support and interpersonal control) predict athletes' engagement and disaffection in youth sport via the satisfaction and frustration of psychological needs (autonomy, competence, and relatedness). Our study extends this research by examining SDT's mediation model longitudinally with three waves of data. Two hundred fifty-two youth sports participants (Mage = 12.98; SD = 1.84; range = 11-17; female n = 67) completed measures of study variables at the start, middle, and end of a competitive soccer season. Cross-lagged path analyses revealed that associations between the two coach motivational styles and athletes' engagement were mediated by psychological need satisfaction. Furthermore, a positive reciprocal association between psychological need satisfaction and engagement emerged over time. This study therefore supports the temporal assumptions underpinning SDT's mediation model but, importantly, evidences a mutually reinforcing interplay between athletes' psychological needs and their engaged behavior

Perfectionism, burnout, and engagement in dance: The moderating role of autonomy support

Previous findings highlight the relationships between 2 × 2 perfectionism and burnout in dancers, but researchers are yet to examine the relationships between 2 × 2 perfectionism and, the opposing outcome of, engagement in dance. Similarly, we know little about the factors that may moderate these relationships. We therefore sought to extend previous research by examining the relationships between 2 × 2 perfectionism and both burnout and engagement in dancers, and by assessing whether autonomy support moderated the relationships between subtypes of perfectionism and the two opposing outcomes. Adolescent dancers (N = 244, female n = 198, M age = 15.00 years, SD = 2.90 years) completed measures capturing four subtypes of perfectionism (pure personal standards perfectionism, pure evaluative concerns perfectionism, mixed perfectionism, and non-perfectionism), burnout dimensions (reduced sense of accomplishment, emotional/physical exhaustion, devaluation), engagement dimensions (confidence, dedication, vigour, enthusiasm), and autonomy support provided by their dance teacher. Moderated regression analyses supported all four hypotheses of the 2 × 2 perfectionism model for burnout (all dimensions) and dedication, vigour, and enthusiasm, and supported three hypotheses for confidence (Hypotheses 1a, 2 and 3). In addition, autonomy support moderated the relationships between subtypes of perfectionism and burnout (reduced accomplishment and devaluation) and engagement (all dimensions). The findings suggest that providing autonomy support offers a potential strategy to prevent burnout and promote engagement in perfectionistic dancers

Passion and burnout in elite junior soccer players: The mediating role of self-determined motivation

Objectives: The purpose of the study was to examine the relationship between forms of passion (harmonious and obsessive; Vallerand et al., 2003) and athlete burnout, and whether these relationships are mediated by self-determined motivation. The proposed model posited that because harmonious passion originates from an authentic self, it will be positively associated with self-determined regulation. Conversely, because obsessive passion originates from ego-invested structures within the self, it will be negatively associated with self-determined regulation. In turn, consistent with research examining the relationship between motivation regulation and athlete burnout, self-determined regulation was expected to be negatively associated with athlete burnout. Design: Cross-sectional survey. Method: This model was tested in 149 (M age¼ 16.2, s ¼ 2.0, range¼ 12e21) male junior athletes who attended soccer academies in the UK. Participants completed the Passion Scale (Vallerand et al., 2003), the Sport Motivation Scale (Pelletier et al., 1995), and the Athlete Burnout Questionnaire (Raedeke & Smith, 2001). Results: Harmonious passion was negatively related to a latent athlete burnout factor, whereas obsessive passion was unrelated to a latent athlete burnout factor. The relationship between harmonious passion and burnout was fully mediated by self-determined regulation. Conclusions: The results suggest that harmonious passion may offer some protection from burnout for athletes due to higher levels of self-determined motivatio

Treatment of bone loss in proximal femurs of postmenopausal osteoporotic women with AGN1 local osteo-enhancement procedure (LOEP) increases hip bone mineral density and hip strength: a long-term prospective cohort study.

This first-in-human study of AGN1 LOEP demonstrated that this minimally-invasive treatment durably increased aBMD in femurs of osteoporotic postmenopausal women. AGN1 resorption was coupled with new bone formation by 12 weeks and that new bone was maintained for at least 5-7 years resulting in substantially increased FEA-estimated femoral strength.IntroductionThis first-in-human study evaluated feasibility, safety, and in vivo response to treating proximal femurs of postmenopausal osteoporotic women with a minimally-invasive local osteo-enhancement procedure (LOEP) to inject a resorbable triphasic osteoconductive implant material (AGN1).MethodsThis prospective cohort study enrolled 12 postmenopausal osteoporotic (femoral neck T-score ≤ - 2.5) women aged 56 to 89 years. AGN1 LOEP was performed on left femurs; right femurs were untreated controls. Subjects were followed-up for 5-7 years. Outcomes included adverse events, proximal femur areal bone mineral density (aBMD), AGN1 resorption, and replacement with bone by X-ray and CT, and finite element analysis (FEA) estimated hip strength.ResultsBaseline treated and control femoral neck aBMD was equivalent. Treated femoral neck aBMD increased by 68 ± 22%, 59 ± 24%, and 58 ± 27% over control at 12 and 24 weeks and 5-7 years, respectively (p < 0.001, all time points). Using conservative assumptions, FEA-estimated femoral strength increased by 41%, 37%, and 22% at 12 and 24 weeks and 5-7 years, respectively (p < 0.01, all time points). Qualitative analysis of X-ray and CT scans demonstrated that AGN1 resorption and replacement with bone was nearly complete by 24 weeks. By 5-7 years, AGN1 appeared to be fully resorbed and replaced with bone integrated with surrounding trabecular and cortical bone. No procedure- or device-related serious adverse events (SAEs) occurred.ConclusionsTreating femurs of postmenopausal osteoporotic women with AGN1 LOEP results in a rapid, durable increase in aBMD and femoral strength. These results support the use and further clinical study of this approach in osteoporotic patients at high risk of hip fracture

Genotoxic agents promote the nuclear accumulation of annexin A2: role of annexin A2 in mitigating DNA damage

Annexin A2 is an abundant cellular protein that is mainly localized in the cytoplasm and plasma membrane, however a small population has been found in the nucleus, suggesting a nuclear function for the protein. Annexin A2 possesses a nuclear export sequence (NES) and inhibition of the NES is sufficient to cause nuclear accumulation. Here we show that annexin A2 accumulates in the nucleus in response to genotoxic agents including gamma-radiation, UV radiation, etoposide and chromium VI and that this event is mediated by the nuclear export sequence of annexin A2. Nuclear accumulation of annexin A2 is blocked by the antioxidant agent N-acetyl cysteine (NAC) and stimulated by hydrogen peroxide (H2O2), suggesting that this is a reactive oxygen species dependent event. In response to genotoxic agents, cells depleted of annexin A2 show enhanced phospho-histone H2AX and p53 levels, increased numbers of p53-binding protein 1 nuclear foci and increased levels of nuclear 8-oxo-2'-deoxyguanine, suggesting that annexin A2 plays a role in protecting DNA from damage. This is the first report showing the nuclear translocation of annexin A2 in response to genotoxic agents and its role in mitigating DNA damage.Natural Sciences and Engineering Research Council of Canada (NSERC); European Union [PCOFUND-GA-2009-246542]; Foundation for Science and Technology of Portugal; Beatrice Hunter Cancer Research Institute; Terry Fox Foundationinfo:eu-repo/semantics/publishedVersio

Causal hierarchy within the thalamo-cortical network in spike and wave discharges

Background: Generalised spike wave (GSW) discharges are the electroencephalographic (EEG) hallmark of absence seizures, clinically characterised by a transitory interruption of ongoing activities and impaired consciousness, occurring during states of reduced awareness. Several theories have been proposed to explain the pathophysiology of GSW discharges and the role of thalamus and cortex as generators. In this work we extend the existing theories by hypothesizing a role for the precuneus, a brain region neglected in previous works on GSW generation but already known to be linked to consciousness and awareness. We analysed fMRI data using dynamic causal modelling (DCM) to investigate the effective connectivity between precuneus, thalamus and prefrontal cortex in patients with GSW discharges. Methodology and Principal Findings: We analysed fMRI data from seven patients affected by Idiopathic Generalized Epilepsy (IGE) with frequent GSW discharges and significant GSW-correlated haemodynamic signal changes in the thalamus, the prefrontal cortex and the precuneus. Using DCM we assessed their effective connectivity, i.e. which region drives another region. Three dynamic causal models were constructed: GSW was modelled as autonomous input to the thalamus (model A), ventromedial prefrontal cortex (model B), and precuneus (model C). Bayesian model comparison revealed Model C (GSW as autonomous input to precuneus), to be the best in 5 patients while model A prevailed in two cases. At the group level model C dominated and at the population-level the p value of model C was ∼1. Conclusion: Our results provide strong evidence that activity in the precuneus gates GSW discharges in the thalamo-(fronto) cortical network. This study is the first demonstration of a causal link between haemodynamic changes in the precuneus - an index of awareness - and the occurrence of pathological discharges in epilepsy. © 2009 Vaudano et al

Routes for breaching and protecting genetic privacy

We are entering the era of ubiquitous genetic information for research, clinical care, and personal curiosity. Sharing these datasets is vital for rapid progress in understanding the genetic basis of human diseases. However, one growing concern is the ability to protect the genetic privacy of the data originators. Here, we technically map threats to genetic privacy and discuss potential mitigation strategies for privacy-preserving dissemination of genetic data.Comment: Draft for comment