Effect of phytase supplementation to barley-canola meal and barley-soybean meal diets on phosphorus and calcium balance in growing pigs

Two metabolism experiments were carried out, to determine the effect of microbial phytase addition to barley-canola meal and barley-soybean meal diets on P and Ca balance in growing. pigs; In experiment 1, six barrows (29.6kg: initial LW) were fed a barley-canola meal diet, without or. with phytase (500 units.kg(-1) ring 24 days, according to a crossover design. The diet provided suboptimal levels. of P. In experiment 2, twelve barrows (53.4kg initial LW) were fed four barley-soybean meal diets, according to a two-period changeover design; Diet 1 was supplemented with inorganic P and Ca to meet requirements,. diets, 2, 3 and 4 contained suboptimal levels of P, diet 3 being supplemented with phytase; diet 4 was supplemented with both phytase and a mixture of xylanase and beta-glucanase. The supplementation of phytase to the barley-canola meal and the barley-soybean meal diets increased (P0.05) values far P retention and P and Ca digestibilities as for diets 1 and 3. In conclusion; phytase supplementation to the barley-canola meal and barley-soybean meal diets improved the utilization of P and digestibility of Ca; but no further effect was observed with the supplementation with the mixture of xylanase and beta-glucanase

Dietary Patterns and Glucose Tolerance Abnormalities in Chinese Adults

OBJECTIVE To investigate the association of the dietary pattern with the presence of newly diagnosed glucose tolerance abnormalities among Chinese adults. RESEARCH DESIGN AND METHODS A total of 20,210 adults aged 45–69 years from the 2002 China National Nutrition and Health Survey were included. Information on dietary intake was collected using a validated food frequency questionnaire. Factor analysis and cluster analysis were used to identify the food factors and dietary pattern clusters. RESULTS Four dietary pattern clusters were identified (“Green Water,” “Yellow Earth,” “Western Adopter,” and “New Affluence”). The prevalence of glucose tolerance abnormalities ranged from 3.9% in the Green Water to 8.0% in the New Affluence. After adjustment for area, age, sex, current smoking, and physical activity, subjects in the Yellow Earth cluster (prevalence ratio 1.22 [95% CI 1.04–1.43]) and New Affluence cluster (2.05 [1.76–2.37]) had significantly higher prevalence rates compared with those for the Green Water cluster. After further adjustment for BMI and waist-to-height ratio, the elevated risk in the New Affluence remained statistically significant. CONCLUSIONS Dietary patterns and food factors are associated with the presence of glucose tolerance abnormalities in China, even independent of obesity. A New Affluence diet is an important modifiable risk factor, which needs attention from the prevention point of vie

Black hole mass and Eddington ratio distributions of less-luminous quasars at z∼4z\sim4 in the Subaru Hyper Suprime-Cam Wide field

We investigate the black hole mass function (BHMF) and Eddington ratio distribution function (ERDF) of broad-line AGNs at z=4, based on a sample of 52 quasars with i<23.2 at 3.50 < z < 4.25 from the Hyper Suprime-Cam Subaru Strategic Program (HSC-SSP) S16A-Wide2 dataset, and 1,462 quasars with i<20.2 in the same redshift range from the Sloan Digital Sky Survey (SDSS) DR7 quasar catalog. Virial BH masses of quasars are estimated using the width of the CIV 1549{\AA} line and the continuum luminosity at 1350{\AA}. To obtain the intrinsic broad-line AGN BHMF and ERDF, we correct for the incompleteness in the low-mass and/or low-Eddington-ratio ranges caused by the flux-limited selection. The resulting BHMF is constrained down to $\log M_{\rm BH}/M_{\odot}\sim7.5$. In comparison with broad-line AGN BHMFs at z=2 in the literature, we find that the number density of massive SMBHs peaks at higher redshifts, consistent with the "down-sizing" evolutionary scenario. Additionally, the resulting ERDF shows a negative dependence on BH mass, suggesting more massive SMBHs tend to accrete at lower Eddington ratios at z=4. With the derived intrinsic broad-line AGN BHMF, we also evaluate the active fraction of broad-line AGNs among the entire SMBH population at z=4. The resulting active fraction may suggest a positive dependence on BH mass. Finally, we examine the time evolution of broad-line AGN BHMF between z=4 and 6 through solving the continuity equation. The results suggest that the broad-line AGN BHMFs at z=4-6 only show evolution in their normalization, but with no significant changes in their shape.Comment: 38 pages, 26 figures. Submitted to ApJ. Data is available in https://github.com/wanqqq31/BHMF_hsc_z

Lamin A/C sustains PcG protein architecture, maintaining transcriptional repression at target genes

Beyond its role in providing structure to the nuclear envelope, lamin A/C is involved in transcriptional regulation. However, its cross talk with epigenetic factors--and how this cross talk influences physiological processes--is still unexplored. Key epigenetic regulators of development and differentiation are the Polycomb group (PcG) of proteins, organized in the nucleus as microscopically visible foci. Here, we show that lamin A/C is evolutionarily required for correct PcG protein nuclear compartmentalization. Confocal microscopy supported by new algorithms for image analysis reveals that lamin A/C knock-down leads to PcG protein foci disassembly and PcG protein dispersion. This causes detachment from chromatin and defects in PcG protein-mediated higher-order structures, thereby leading to impaired PcG protein repressive functions. Using myogenic differentiation as a model, we found that reduced levels of lamin A/C at the onset of differentiation led to an anticipation of the myogenic program because of an alteration of PcG protein-mediated transcriptional repression. Collectively, our results indicate that lamin A/C can modulate transcription through the regulation of PcG protein epigenetic factors

Tyrosine-610 in the receptor kinase BAK1 does not play a major role in brassinosteroid signaling or innate immunity

The plasma membrane-localized BRI1-ASSOCIATED KINASE1 (BAK1) functions as a co-receptor with several receptor kinases including the brassinosteroid (BR) receptor BRASSINOSTEROID-INSENSITIVE 1 (BRI1), which is involved in growth, and the receptors for bacterial flagellin and EF-Tu, FLAGELLIN-SENSING 2 (FLS2) and EF-TU RECEPTOR (EFR), respectively, which are involved in immunity. BAK1 is a dual specific protein kinase that can autophosphorylate on serine, threonine and tyrosine residues. It was previously reported that phosphorylation of Tyr-610 in the carboxy-terminal domain of BAK1 is required for its function in BR signaling and immunity. However, the functional role of Tyr-610 in vivo has recently come under scrutiny. Therefore, we have generated new BAK1(Y610F) transgenic plants for functional studies. We first produced transgenic Arabidopsis expressing BAK1 (Y610F)-Flag in the homozygous bak1-4 bkk1-1 double null background. In a complementary approach, we expressed untagged BAK1 and BAK1(Y610F) in the bak1-4 null mutant. Both BAK1(Y610F) transgenic lines had no obvious growth phenotype compared to wild-type BAK1 expressed in the same background. In addition, the BAK1(Y610F)-Flag plants responded similarly to plants expressing BAK1-Flag in terms of brassinolide (BL) inhibition of root elongation, and there were only minor changes in gene expression between the two transgenic lines as monitored by microarray analysis and real-time PCR. In terms of plant immunity, there were no significant differences between plants expressing BAK1(Y610F)-Flag and BAK1-Flag in the growth of the non-pathogenic hrpA mutant of Pseudomonas syringae pv. tomato DC3000. Furthermore, untagged BAK1(Y610F) transgenic plants were as responsive as plants expressing BAK1 (in the bak1-4 background) and wild-type Col-0 plants towards treatment with the EF-Tu- and flagellin-derived peptide epitopes elf18- and flg22, respectively, as measured by reactive oxygen species (ROS) production, mitogen-activated protein kinase (MAPK) activation, and seedling growth inhibition. Together, these new results demonstrate that Tyr-610 does not play a role in either BR or immune signaling

ππ\pi\pi scattering in the ρ\rho-meson channel at finite temperature

We study $\pi\pi$ scattering in the I=1, $J^P=1^-$ channel at finite temperature in the framework of the extended Nambu-Jona-Lasinio model that explicitly includes vector and axial-vector degrees of freedom in addition to the usual scalar and pseudoscalar sector. The S-matrix in the coupled channels $q\bar q$ and $\pi \pi$ is constructed via $\rho$-exchange in the $s$-channel. The self-energy of the $\rho$-meson contains both quark and pion loop contributions. The analytic structure of the S-matrix for $T\geq 0$ is investigated and the motion of the $\rho$-pole as a function of coupling constant and temperature is followed in the complex $\sqrt{s}$-plane. For numerical calculations, parameters are chosen in order that $m_\pi$, $f_\pi$ and the experimental $\pi\pi$ phase shifts $\delta_1^1$ at zero temperature are reproduced, and then the behavior of the $\rho$-pole as well as the $\pi\pi$ cross section is investigated as a function of the temperature. We find that the position of the $\rho$ mass stays practically constant for $0\leq T\leq 130$ MeV, and then moves down in energy by about 200 MeV for 130 MeV$\leq T\leq 230$ MeV.Comment: 25 pages, 12 figures, to appear in Nucl. Phys.

Nonlinear Supersymmetry as a Hidden Symmetry

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