Neurofibromatosis (von Recklinghausen's disease) - An unusual cause of parenchymal lung disease : a case report

CITATION: Hardcastle, S. W. & Hendricks, M. L. 1984. Neurofibromatosis (von Recklinghausen's disease) - An unusual cause of parenchymal lung disease : a case report. South African Medical Journal, 66:959-960.The original publication is available at http://www.samj.org.zaInterstitial pulmonary fibrosis and bullae are uncommon findings in neurofibromatosis. A case of this disease with pulmonary parenchymal involvement is presented and the association between the two is discussed.Publisher’s versio

A Chandra study of particle acceleration in the multiple hotspots of nearby radio galaxies

We present Chandra observations of a small sample of nearby classical double radio galaxies which have more than one radio hotspot in at least one of their lobes. The X-ray emission from the hotspots of these comparatively low-power objects is expected to be synchrotron in origin, and therefore to provide information about the locations of high-energy particle acceleration. In some models of the relationship between the jet and hotspot the hotspots that are not the current jet termination point should be detached from the energy supply from the active nucleus and therefore not capable of accelerating particles to high energies. We find that in fact some secondary hotspots are X-ray sources, and thus probably locations for high-energy particle acceleration after the initial jet termination shock. In detail, though, we show that the spatial structures seen in X-ray are not consistent with naive expectations from a simple shock model: the current locations of the acceleration of the highest-energy observable particles in powerful radio galaxies need not be coincident with the peaks of radio or even optical emission.Comment: Accepted for ApJ. 33 pages, 8 figures inc. 2 in colo

A Chandra Study of the Lobe/ISM Interactions Around the Inner Radio Lobes of Centaurus A: Constraints on the Temperature Structure and Transport Processes

We present results from deeper {\em Chandra} observations of the southwest radio lobe of Centaurus A, first described by Kraft et al. (2003). We find that the sharp X-ray surface brightness discontinuity extends around $\sim$75% of the periphery of the radio lobe, and detect significant temperature jumps in the brightest regions of this discontinuity nearest to the nucleus. This demonstrates that this discontinuity is indeed a strong shock which is the result of an overpressure which has built up in the entire lobe over time. Additionally, we demonstrate that if the mean free path for ions to transfer energy and momentum to the electrons behind the shock is as large as the Spitzer value, the electron and proton temperatures will not have equilibrated along the SW boundary of the radio lobe where the shock is strongest. Thus the proton temperature of the shocked gas could be considerably larger than the observed electron temperature, and the total energy of the outburst correspondingly larger as well. We investigate this using a simple one-dimensional shock model for a two-fluid (proton/electron) plasma. We find that for the thermodynamic parameters of the Cen A shock the electron temperature rises rapidly from $\sim$0.29 keV (the temperature of the ambient ISM) to $\sim$3.5 keV at which point heating from the protons is balanced by adiabatic losses. The proton and electron temperatures do not equilibrate in a timescale less than the age of the lobe. We note that the measured electron temperature of similar features in other nearby powerful radio galaxies in poor environments may considerably underestimate the strength and velocity of the shock.Comment: 29 pages, 9 figures, 2 tables - accepted for publication in the Astrophysical Journa

Sub-Arcsecond Imaging of 3C123:108-GHz Continuum Observations of the Radio Hotspots

We present the results of sub-arcsecond 108 GHz continuum interferometric observations toward the radio luminous galaxy 3C123. Using multi-array observations, we utilize the high u,v dynamic range of the BIMA millimeter array to sample fully spatial scales ranging from 0.5" to 50". This allows us to make one-to-one comparisons of millimeter-wavelength emission in the radio lobes and hotspots to VLA centimeter observations at 1.4, 4.9, 8.4, and 15 GHz. At 108 GHz, the bright, eastern double hotspot in the southern lobe is resolved. This is only the second time that a multiple hotspot region has been resolved in the millimeter regime. We model the synchrotron spectra of the hotspots and radio lobes using simple broken power-law models with high energy cutoffs, and discuss the hotspot spectra and their implications for models of multiple hotspot formation.Comment: 16 pages, 3 Figures, ApJ Accepte

A LOFAR mini-survey for low-frequency radio emission from the nearest brown dwarfs

We have conducted a mini-survey for low-frequency radio emission from some of the closest brown dwarfs to the Sun with rapid rotation rates: SIMP J013656.5 +093347, WISEPC 150649.97+702736.0, and WISEPA J174124.26+255319.5.We have placed robust 3s upper limits on the flux density in the 111 – 169 MHz frequency range for these targets: WISE 1506: < 0:72 mJy; WISE 1741: < 0:87 mJy; SIMP 0136: < 0:66 mJy. At 8 hours of integration per target to achieve these limits, we find that systematic and detailed study of this class of object at LOFAR frequencies will require a substantial dedication of resources

The Hot Gas Environment of the Radio Galaxy 3C 388: Quenching the Accumulation of Cool Gas in a Cluster Core by a Nuclear Outburst

We present results from a 35 ks {\em Chandra}/ACIS-I observation of the hot ICM around the FR II radio galaxy 3C 388. 3C 388 resides in a cluster environment with an ICM temperature of $\sim$3.5 keV. We detect cavities in the ICM coincident with the radio lobes. The enthalpy of these cavities is $\sim1.2\times10^{60}$ ergs. The work done on the gas by the inflation of the lobes is $\sim3\times10^{59}$ ergs, or $\sim$0.87 keV per particle out to the radius of the lobes. The radiative timescale for gas at the center of the cluster at the current temperature is a few Gyrs. The gas in the core was probably cooler and denser before the outburst, so the cooling time was considerably shorter. We are therefore likely to be witnessing the quenching of a cluster cooling flow by a radio galaxy outburst. The mechanical power of the lobes is at least 20 times larger than the radiative losses out to the cooling radius. Outbursts of similar power with a $\sim$5% duty cycle would be more than sufficient to continually reheat the cluster core over the Hubble time and prevent the cooling of any significant amount of gas. The mechanical power of the outburst is also roughly two orders of magnitude larger than either the X-ray luminosity of the active nucleus or the radio luminosity of the lobes. The equipartition pressure of the radio lobes is more than an order of magnitude lower than that of the ambient medium, indicating that the pressure of the lobe is dominated by something other than the relativistic electrons radiating at GHz frequencies.Comment: 28 pages, 10 figures - accepted for publication in the Astrophysical Journa

Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitorD9331

Uracil DNA misincorporation and misrepair of DNA have been recognized as important events accompanying thymidylate synthase (TS) inhibition. dUTPase catalyses the hydrolysis of dUTP to dUMP, thereby maintaining low intracellular dUTP. We have addressed the relationship between dUTPase expression and cellular sensitivity to TS inhibition in four human lung tumour cell lines. Sensitivity (5-day MTT assay) to the growth inhibitory effects of the non-polyglutamatable, specific quinazoline TS inhibitor ZD9331, varied up to 20-fold (IC 50 3–70 nM). TS protein expression correlated with TS activity (r2= 0.88 P= 0.05). Intracellular concentrations of drug following exposure to ZD9331 (1 μM, 24 h) varied by ~2-fold and dTTP pools decreased by > 80% in all cell lines. No clear associations across the cell lines between intracellular drug concentrations, TS activity/expression, or TTP depletion could be made. dUTPase activity varied 17-fold and correlated with dUTPase protein expression (r2= 0.94 P= 0.03). There was a striking variation in the amount of dUTP formed following exposure to ZD9331 (between 1.3 and 57 pmole 10–6cells) and was in general inversely associated with dUTPase activity. A large expansion in the dUTP pool was associated with increased sensitivity to a 24-h exposure to ZD9331 in A549 cells that have low dUTPase activity/expression. dUTPase expression and activity were elevated (approximately 3-fold) in two variants of a human lymphoblastoid cell line with acquired resistance to TS inhibitors, further suggesting an important role for this enzyme in TS inhibited cells. © 2000 Cancer Research Campaig

LOFAR early-time search for coherent radio emission from GRB 180706A

© 2019 The Author(s) Published by Oxford University Press on behalf of the Royal Astronomical Society.The nature of the central engines of gamma-ray bursts (GRBs) and the composition of their relativistic jets are still under debate. If the jets are Poynting flux dominated rather than baryon dominated, a coherent radio flare from magnetic re-connection events might be expected with the prompt gamma-ray emission. There are two competing models for the central engines of GRBs; a black hole or a newly formed milli-second magnetar. If the central engine is a magnetar it is predicted to produce coherent radio emission as persistent or flaring activity. In this paper, we present the deepest limits to date for this emission following LOFAR rapid response observations of GRB 180706A. No emission is detected to a 3$\sigma$ limit of 1.7 mJy beam$^{-1}$ at 144 MHz in a two-hour LOFAR observation starting 4.5 minutes after the gamma-ray trigger. A forced source extraction at the position of GRB 180706A provides a marginally positive (1 sigma) peak flux density of $1.1 \pm 0.9$ mJy. The data were time-sliced into different sets of snapshot durations to search for FRB like emission. No short duration emission was detected at the location of the GRB. We compare these results to theoretical models and discuss the implications of a non-detection.Peer reviewedFinal Accepted Versio

Extended soft X-ray emission in 3CR radio galaxies at z < 0.3: High Excitation and Broad Line Galaxies

We analyze Chandra observations of diffuse soft X-ray emission associated with a complete sample of 3CR radio galaxies at z < 0.3. In this paper we focus on the properties of the spectroscopic sub-classes of high excitation galaxies (HEGs) and broad line objects (BLOs). Among the 33 HEGs we detect extended (or possibly extended) emission in about 40% of the sources; the fraction is even higher (8/10) restricting the analysis to the objects with exposure times larger than 10 ks. In the 18 BLOs, extended emission is seen only in 2 objects; this lower detection rate can be ascribed to the presence of their bright X-ray nuclei that easily outshine any genuine diffuse emission. A very close correspondence between the soft X-ray and optical line morphology emerges. We also find that the ratio between [O III] and extended soft X-ray luminosity is confined within a factor of 2 around a median value of 5. Both results are similar to what is seen in Seyfert galaxies. We discuss different processes that could explain the soft X-ray emission and conclude that the photoionization of extended gas, coincident with the narrow line region, is the favored mechanism.Comment: 15 pages, 11 figures. Accepted for publication on A&

The origins of X-ray emission from the hotspots of FRII radio sources

We use new and archival Chandra data to investigate the X-ray emission from a large sample of compact hotspots of FRII radio galaxies and quasars from the 3C catalogue. We find that only the most luminous hotspots tend to be in good agreement with the predictions of a synchrotron self-Compton model with equipartition magnetic fields. At low hotspot luminosities inverse-Compton predictions are routinely exceeded by several orders of magnitude, but this is never seen in more luminous hotspots. We argue that an additional synchrotron component of the X-ray emission is present in low-luminosity hotspots, and that the hotspot luminosity controls the ability of a given hotspot to produce synchrotron X-rays, probably by determining the high-energy cutoff of the electron energy spectrum. It remains plausible that all hotspots are close to the equipartition condition.Comment: 49 pages, 16 figures. ApJ accepted. Revised version fixes a typo in one of the Tables and corrects a statement about 3C27