Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Sensitivity of ARGO-YBJ to different composition models in the energy range 10 ÷ 500 TeV

The ARGO-YBJ experiment is currently under construction at the Yangbajing Cosmic Ray Laboratory (4300 m a.s.l.).The detector consists of a central carpet, 74 × 78 m2, made of a single layer of Resistive Plate Counters (RPCs), and surrounded by a partially instrumented guard ring for a total instrumented area of about 6700 m2. The digital read-out, performed by means of pick-up electrodes 6.7 × 62 cm2 (strip), allows to measure the charged particle number of small size air showers. The technique of counting the number of fired strips on the ARGO carpet corresponds to operate in the 10÷500 TeV energy region where both direct and indirect measurements on the primary cosmic radiation have been performed. Many composition models have been proposed by different experiments. In this work we discuss the ability of the ARGO detector to discriminate among some models

Results of the ARGO-YBJ test experiment

A resistive plate counters (RPCs) carpet of ∼50 m2 has been put in operation in the Yangbajing Laboratory (Tibet, P.R. China) at 4300 m a.s.l., in order to study the RPCs performance at high altitude and the detector capability of imaging the EAS disc. This test has been performed in view of an enlarged use of RPCs for the ARGO-YBJ experiment. This experiment will be devoted to a wide range of fundamental issues in cosmic rays and astroparticle physics, including in particular γ-ray astronomy and γ-ray bursts physics at energies ⩾100 GeV. In this paper we present and discuss the procedures adopted to calibrate the detector and reconstruct the shower direction. Results concerning many shower features as the angular distribution, the density spectrum, the time profile of the shower front, are found well consistent with the expectation

Results from the Analysis of data collected with a 50m2 RPC carpet at Yangbajing

An RPC carpet covering View the MathML source (ARGO-YBJ experiment) will be installed in the YangBaJing Laboratory (Tibet, People's Republic of China) at an altitude of 4300 m a.s.l. A test-module of View the MathML source has been put in operation in this laboratory and about 106 air shower events have been collected. The RPC performance at high altitude and the carpet capability of reconstructing the shower features are presented

Performance of the RPCs for the ARGO detector operated at the YangBaJing Laboratory (4300 m a.s.l.)

Bakelite RPCs, assembled according to the ARGO design, have been operated in the high altitude Laboratory of YBJ using dedicated electronics to pick-up the streamer signal. Here we report on the results concerning absorbed current, single counting rate, efficiency and time resolution. Environmental data concerning the operating temperature inside the ARGO experimental hall are also reported