127 research outputs found
Notes on Practice of Medicine, from Prof. Da Costa\u27s Lectures, at The Jefferson Medical College, During Sessions of [18]84-85 and [18]85-86
Notes from the lectures of Jacob Mendes Da Costa taken by 1887 graduate of Jefferson Medical College William W. H. Wehner. Jacob Mendes Da Costa served in the U.S. Army during the American Civil War and undertook research on irritable heart (neurocirculatory asthenia) in soldiers, research that was of landmark importance in clinical medicine. After the Civil War, Da Costa continued his teaching at the Pennsylvania Hospital (1865-1900). He began at Jefferson Medical College as a lecturer on clinical medicine (1866-1872), then professor of theory and practice of medicine (1872-1891), and finally professor emeritus (1891-1900). While Da Costa retired in 1891, he continued his medical efforts as a consultant and supporter for medical education reform and served as a trustee of the University of Pennsylvania in 1899 (University Archives and Special Collections). Notes in this book include Da Costa\u27s lectures on typhoid, malaria, yellow fever, small pox, and a host of other diseases. 179 pages.
Reference:
University Archives and Special Collections of Thomas Jefferson University. 10 Notable Jefferson Alumni of the Past: Jacob Mendes Da Costa. Retrieved from: http://jeffline.jefferson.edu/SML/archives/exhibits/notable_alumni/jacob_mendes_dacosta.htmlhttps://jdc.jefferson.edu/medicalnotebooks/1001/thumbnail.jp
Stability of the Scalar Potential and Symmetry Breaking in the Economical 3-3-1 Model
A detailed study of the criteria for stability of the scalar potential and
the proper electroweak symmetry breaking pattern in the economical 3-3-1 model,
is presented. For the analysis we use, and improve, a method previously
developed to study the scalar potential in the two-Higgs-doublet extension of
the standard model. A new theorem related to the stability of the potential is
stated. As a consequence of this study, the consistency of the economical 3-3-1
model emerges.Comment: to be published in EPJ C, 13 page
Biomimetic Sniffing Improves the Detection Performance of a 3D Printed Nose of a Dog and a Commercial Trace Vapor Detector
Unlike current chemical trace detection technology, dogs actively sniff to acquire an odor sample. Flow visualization experiments with an anatomically-similar 3D printed dog’s nose revealed the external aerodynamics during canine sniffing, where ventral-laterally expired air jets entrain odorant-laden air toward the nose, thereby extending the “aerodynamic reach” for inspiration of otherwise inaccessible odors. Chemical sampling and detection experiments quantified two modes of operation with the artificial nose-active sniffing and continuous inspiration-and demonstrated an increase in odorant detection by a factor of up to 18 for active sniffing. A 16-fold improvement in detection was demonstrated with a commercially-available explosives detector by applying this bio-inspired design principle and making the device “sniff” like a dog. These lessons learned from the dog may benefit the next-generation of vapor samplers for explosives, narcotics, pathogens, or even cancer, and could inform future bio-inspired designs for optimized sampling of odor plumes.United States. Department of Homeland Security. Advanced Research Projects Agency (Interagency Agreement HSHQPM-13-X-00107)United States. Air Force (Contract FA8721-05-C-0002)United States. Air Force (Contract FA8702-15-D-0001
SU(3)_c X SU(4)_L X U(1)_x without exotic electric charges
We present an extension of the Standard Model to the local gauge group
with a family non-universal treatment
and anomalies canceled among the three families in a nontrivial fashion. The
mass scales, the gauge boson masses, and the masses for the spin 1/2 particles
in the model are analyzed. The neutral currents coupled to all neutral vector
bosons in the model are studied, and particular values of the parameters are
used in order to simplify the mixing between the three neutral currents present
in the theory, mixing which is further constrained by experimental results from
the CERN LEP, SLAC Linear Collider, and atomic parity violation.Comment: RevTeX, 11 pages, 1 figure. Several formulas corrected. One reference
added. Accepted for publication in Phys. Rev.
Determination of the Deep Inelastic Contribution to the Generalised Gerasimov-Drell-Hearn Integral for the Proton and Neutron
The virtual photon absorption cross section differences [sigma_1/2-sigma_3/2]
for the proton and neutron have been determined from measurements of polarised
cross section asymmetries in deep inelastic scattering of 27.5 GeV
longitudinally polarised positrons from polarised 1H and 3He internal gas
targets. The data were collected in the region above the nucleon resonances in
the kinematic range nu < 23.5 GeV and 0.8 GeV**2 < Q**2 < 12 GeV**2. For the
proton the contribution to the generalised Gerasimov-Drell-Hearn integral was
found to be substantial and must be included for an accurate determination of
the full integral. Furthermore the data are consistent with a QCD
next-to-leading order fit based on previous deep inelastic scattering data.
Therefore higher twist effects do not appear significant.Comment: 6 pages, 3 figures, 1 table, revte
Scalar Potential Without Cubic Term in 3-3-1 Models Without Exotic Electric Charges
A detailed study of the criteria for stability of the scalar potential, and
the proper electroweak symmetry breaking pattern in some 3-3-1 models without
exotic electric charges is presented. In this paper we concentrate in a scalar
sector with three Higgs scalar triplets, with a potential that does not include
the cubic term, due to the presence of a discrete symmetry. For the analysis we
use, and improve, a method previously developed to study the scalar potential
in the two-Higgs-doublet extension of the standard model. Our main result is to
show the consistency of those 3-3-1 models without exotic electric charges.Comment: 19 page
SU(3)c⊗SU(3)L⊗U(1)x as an SU(6)⊗U(1)x subgroup
ABSTRACT: An extension of the standard model to the local gauge group SU(3) c ^ SU(3)L ^ U(1)X as a family independent model is presented. The mass scales, the gauge boson masses, and the masses for the spin 1/2 particles in the model are studied. The mass differences between the up and down quark sectors, between the quarks and leptons, and between the charged and neutral leptons in one family are analyzed. The existence of two Dirac neutrinos for each family, one light and one very heavy, is predicted. By using experimental results from CERN LEP, SLC and atomic parity violation we constrain the mixing angle between the two neutral currents and the mass of the additional neutral gauge boson to be 20.00015<sin u<0 and 1.5 TeV<MZ2 at 95% C.L
RANTES/CCL5 and risk for coronary events: Results from the MONICA/KORA Augsburg case-cohort, Athero-express and CARDIoGRAM studies
Background: The chemokine RANTES (regulated on activation, normal T-cell expressed and secreted)/CCL5 is involved in the pathogenesis of cardiovascular disease in mice, whereas less is known in humans. We hypothesised that its relevance for atherosclerosis should be reflected by associations between CCL5 gene variants, RANTES serum concentrations and protein levels in atherosclerotic plaques and risk for coronary events. Methods and Findings: We conducted a case-cohort study within the population-based MONICA/KORA Augsburg studies. Baseline RANTES serum levels were measured in 363 individuals with incident coronary events and 1,908 non-cases (mean follow-up: 10.2±
Fine-Scale Mapping of the 4q24 Locus Identifies Two Independent Loci Associated with Breast Cancer Risk
Background: A recent association study identified a common variant (rs9790517) at 4q24 to be associated with breast cancer risk. Independent association signals and potential functional variants in this locus have not been explored.
Methods: We conducted a fine-mapping analysis in 55,540 breast cancer cases and 51,168 controls from the Breast Cancer Association Consortium.
Results: Conditional analyses identified two independent association signals among women of European ancestry, represented by rs9790517 [conditional P = 2.51 × 10−4; OR, 1.04; 95% confidence interval (CI), 1.02–1.07] and rs77928427 (P = 1.86 × 10−4; OR, 1.04; 95% CI, 1.02–1.07). Functional annotation using data from the Encyclopedia of DNA Elements (ENCODE) project revealed two putative functional variants, rs62331150 and rs73838678 in linkage disequilibrium (LD) with rs9790517 (r2 ≥ 0.90) residing in the active promoter or enhancer, respectively, of the nearest gene, TET2. Both variants are located in DNase I hypersensitivity and transcription factor–binding sites. Using data from both The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC), we showed that rs62331150 was associated with level of expression of TET2 in breast normal and tumor tissue.
Conclusion: Our study identified two independent association signals at 4q24 in relation to breast cancer risk and suggested that observed association in this locus may be mediated through the regulation of TET2.
Impact: Fine-mapping study with large sample size warranted for identification of independent loci for breast cancer risk
Novas evidências documentais para a história da homeopatia na América Latina: um estudo de caso sobre os vínculos entre Rio de Janeiro e Buenos Aires
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