Two-parameter neutrino mass matrices with two texture zeros

We reanalyse Majorana-neutrino mass matrices M_nu with two texture zeros, by searching for viable hybrid textures in which the non-zero matrix elements of M_nu have simple ratios. Referring to the classification scheme of Frampton, Glashow and Marfatia, we find that the mass matrix denoted by A1 allows the ratios (M_nu)_{mu mu} : (Mnu)_{tau tau} = 1:1 and (M_nu)_{e tau} : (Mnu)_{mu tau} = 1:2. There are analogous ratios for texture A2. With these two hybrid textures, one obtains, for instance, good agreement with the data if one computes the three mixing angles in terms of the experimentally determined mass-squared differences Delta m^2_21 and Delta m^2_31. We could not find viable hybrid textures based on mass matrices different from those of cases A1 and A2.Comment: 10 pages, no figures, minor changes, some references adde

Well-defined regions of the Plasmodium falciparum reticulocyte binding protein homologue 4 mediate interaction with red blood cell membrane

Two widely studied parasite protein families are considered attractive targets for developing a fully effective antimalarial vaccine: the erythrocyte binding antigen (EBA) family defining a sialic acid-dependent invasion pathway, and reticulocyte-binding homologue (RH) proteins associated with sialic acid-independent red blood cell (RBC) invasion. In this study, the micronemal invasive PfRH4 protein was finely mapped using 20-mer-long synthetic peptides spanning the entire protein length to identify protein regions that establish high affinity interactions with human RBCs. Twenty conserved, mainly ?-helical high-activity binding peptides (HABPs) with nanomolar dissociation constants and recognizing 32, 25, 22, and 20 kDaRBCmembrane molecules in a chymotrypsin and/or trypsin-sensitive manner were identified in this protein. Anti-PfRH4 rabbit sera and PfRH4 HABPs inhibited merozoite invasion in vitro, therefore suggesting the implication of these HABPs in Plasmodium falciparum invasion and supporting their inclusion in further structural and immunological studies to design potential components of a minimal subunit-based, multiantigenic, chemically synthesized antimalarial vaccine. ©2009 American Chemical Society

Computational calculation of the magnetic properties of MnO/ZnO superlattice

En este trabajo se realizaron cálculos por primeros principios basados en la Teoría del Funcional de la Densidad, con el fin de investigar las propiedades estructurales, electrónicas y magnéticas de la superred MnO/ZnO en la estructura wurtzita. Se utilizó el método Ondas Plana Aumentadas y Linealizadas Potencial Completo (FP LAPW), tal como está implementado en el código computacional Wien2k. Los efectos de intercambio y de correlación entre los electrones fueron tratados por medio de la Aproximación de Gradiente Generalizado (GGA) de Pedew, Burke y Ernzerhof (PBE). El análisis de las propiedades estructurales muestran que el valor del módulo de volumen es alto, por tanto, esta superred es bastante rígida y es buena candidata para aplicaciones en dispositivos que deban trabajar altas temperaturas, altas potencias y en recubrimientos duros. Los estudios de la densidad estados muestran que la superred posee un comportamiento semimetálicos con polarización de espín en el estado base del 100% y un momento magnético de 5 μβ/atomo-Mn, el estado ferromagnético proviene de la hibridación y polarización de los estados Mn-3d en mayor contribución y de los orbitales O-2p en menor contribución que atraviesan el nivel de Fermi. Debido a esta propiedad la superred puede ser potencialmente usada en espintrónica.First-principle calculations were performed in order to investigate the structural, electronic and magnetic properties of 1x1 MnO/ZnO superlattice in the wurtzite-type structure. The full-potential linearized augmented-plane-wave (FP-LAPW) method was used, as implemented in the WIEN2k computational code. Exchange and correlation effects are treated using the generalized gradient approximation (GGA) of PerdewBurke-Ernzerhof (PBE). The analyze of the structural properties show that the value of the bulk moduli is high, therefore is quite rigid and this feature makes them good candidates for possible application in devices that have to operate at high temperatures, under high power, and in hard coatings. The electronic density studies show that the MnO/ZnO superlattice have a half-metallic behavior with a magnetic spin polarization of 100% and a magnetic moment of 5 µβ/atom-Mn in the ground state. The ferromagnetic state comes from the hybridization of the Mn-3d and O-2p states that cross the Fermi level. This superlattice is a good candidate for spintronic applications

The Glial Regenerative Response to Central Nervous System Injury Is Enabled by Pros-Notch and Pros-NFκB Feedback

Organisms are structurally robust, as cells accommodate changes preserving structural integrity and function. The molecular mechanisms underlying structural robustness and plasticity are poorly understood, but can be investigated by probing how cells respond to injury. Injury to the CNS induces proliferation of enwrapping glia, leading to axonal re-enwrapment and partial functional recovery. This glial regenerative response is found across species, and may reflect a common underlying genetic mechanism. Here, we show that injury to the Drosophila larval CNS induces glial proliferation, and we uncover a gene network controlling this response. It consists of the mutual maintenance between the cell cycle inhibitor Prospero (Pros) and the cell cycle activators Notch and NFκB. Together they maintain glia in the brink of dividing, they enable glial proliferation following injury, and subsequently they exert negative feedback on cell division restoring cell cycle arrest. Pros also promotes glial differentiation, resolving vacuolization, enabling debris clearance and axonal enwrapment. Disruption of this gene network prevents repair and induces tumourigenesis. Using wound area measurements across genotypes and time-lapse recordings we show that when glial proliferation and glial differentiation are abolished, both the size of the glial wound and neuropile vacuolization increase. When glial proliferation and differentiation are enabled, glial wound size decreases and injury-induced apoptosis and vacuolization are prevented. The uncovered gene network promotes regeneration of the glial lesion and neuropile repair. In the unharmed animal, it is most likely a homeostatic mechanism for structural robustness. This gene network may be of relevance to mammalian glia to promote repair upon CNS injury or disease

Scanned Probe Microscopy of Electronic Transport in Carbon Nanotubes

We use electrostatic force microscopy and scanned gate microscopy to probe the conducting properties of carbon nanotubes at room temperature. Multi-walled carbon nanotubes are shown to be diffusive conductors, while metallic single-walled carbon nanotubes are ballistic conductors over micron lengths. Semiconducting single-walled carbon nanotubes are shown to have a series of large barriers to conduction along their length. These measurements are also used to probe the contact resistance and locate breaks in carbon nanotube circuits.Comment: 4 page

Workshop on immunotherapy combinations. Society for immunotherapy of cancer annual meeting Bethesda, November 3, 2011

Although recent FDA approvals on ipilimumab and sipuleucel-T represent major milestones, the ultimate success of immunotherapy approaches will likely benefit from appropriate combinations with other immunotherapeutic and/or non-immunotherapeutic approaches. However, implementation of ideal combinations in the clinic may still face formidable challenges in regulatory, drug-availability and intellectual property aspects. The 2011 SITC annual meeting hosted a workshop on combination immunotherapy to discuss: 1) the most promising combinations found in the laboratory; 2) early success of combination immunotherapy in clinical trials; 3) industry perspectives on combination approaches, and 4) relevant regulatory issues. The integrated theme was how to accelerate the implementation of efficacious combined immunotherapies for cancer patients. Rodent animal models are providing many examples of synergistic combinations that typically include more than two agents. However, mouse and human immunology differ in a significant number of mechanisms and hence we might be missing opportunities peculiar to humans. Nonetheless, incisive animal experimentation with deep mechanistic insight remains the best compass that we can use to guide our paths in combinatorial immunotherapy. Combination immunotherapy clinical trials are already in progress and preliminary results are extremely promising. As a key to translate promising combinations into clinic, real and “perceived” business and regulatory hurdles were debated. A formidable step forward would be to be able to test combinations of investigational agents prior to individual approval. Taking together the FDA and the industrial perspective on combinatorial immunotherapy, the audience was left with the clear message that this is by no means an impossible task. The general perception is that the road ahead of us is full of combination clinical trials which hopefully will bring clinical benefit to our cancer patients at a fast pace

Bullying girls - Changes after brief strategic family therapy: A randomized, prospective, controlled trial with one-year follow-up

Background: Many girls bully others. They are conspicuous because of their risk-taking behavior, increased anger, problematic interpersonal relationships and poor quality of life. Our aim was to determine the efficacy of brief strategic family therapy (BSFT) for bullying-related behavior, anger reduction, improvement of interpersonal relationships, and improvement of health-related quality of life in girls who bully, and to find out whether their expressive aggression correlates with their distinctive psychological features. Methods: 40 bullying girls were recruited from the general population: 20 were randomly selected for 3 months of BSFT. Follow-up took place 12 months after the therapy had ended. The results of treatment were examined using the Adolescents' Risk-taking Behavior Scale (ARBS), the State-Trait Anger Expression Inventory (STAXI), the Inventory of Interpersonal Problems (IIP-D), and the SF-36 Health Survey (SF-36). Results: In comparison with the control group (CG) (according to the intent-to-treat principle), bullying behavior in the BSFT group was reduced (BSFT-G from n = 20 to n = 6; CG from n = 20 to n = 18, p = 0.05) and statistically significant changes in all risk-taking behaviors (ARBS), on most STAXI, IIP-D, and SF-36 scales were observed after BSFT. The reduction in expressive aggression (Anger-Out scale of the STAXI) correlated with the reduction on several scales of the ARBS, IIP-D, and SF-36. Follow-up a year later showed relatively stable events. Conclusions: Our findings suggest that bullying girls suffer from psychological and social problems which may be reduced by the use of BSFT. Expressive aggression in girls appears to correlate with several types of risk-taking behavior and interpersonal problems, as well as with health-related quality of life. Copyright (c) 2006 S. Karger AG, Basel

Potential of optimized NOvA for large theta(13) & combined performance with a LArTPC & T2K

NOvA experiment has reoptimized its event selection criteria in light of the recently measured moderately large value of theta(13). We study the improvement in the sensitivity to the neutrino mass hierarchy and to leptonic CP violation due to these new features. For favourable values of deltacp, NOvA sensitivity to mass hierarchy and leptonic CP violation is increased by 20%. Addition of 5 years of neutrino data from T2K to NOvA more than doubles the range of deltacp for which the leptonic CP violation can be discovered, compared to stand alone NOvA. But for unfavourable values of deltacp, the combination of NOvA and T2K are not enough to provide even a 90% C.L. hint of hierarchy discovery. Therefore, we further explore the improvement in the hierarchy and CP violation sensitivities due to the addition of a 10 kt liquid argon detector placed close to NOvA site. The capabilities of such a detector are equivalent to those of NOvA in all respects. We find that combined data from 10 kt liquid argon detector (3 years of nu + 3 years of nubar run), NOvA (6 years of nu + 6 years of nubar run) and T2K (5 years of nu run) can give a close to 2 sigma hint of hierarchy discovery for all values of deltacp. With this combined data, we can achieve CP violation discovery at 95% C.L. for roughly 60% values of deltacp.Comment: 22 pages, 24 pdf figures, 5 tables. In the appendix, new results are presented with conservative choices of central values of oscillation parameters. New references are added. Accepted in JHE

Reconstructing the Cosmic Velocity and Tidal Fields with Galaxy Groups Selected from the Sloan Digital Sky Survey

[abridge]Cosmic velocity and tidal fields are important for the understanding of the cosmic web and the environments of galaxies, and can also be used to constrain cosmology. In this paper, we reconstruct these two fields in SDSS volume from dark matter halos represented by galaxy groups. Detailed mock catalogues are used to test the reliability of our method against uncertainties arising from redshift distortions, survey boundaries, and false identifications of groups by our group finder. We find that both the velocity and tidal fields, smoothed on a scale of ~2Mpc/h, can be reliably reconstructed in the inner region (~66%) of the survey volume. The reconstructed tidal field is used to split the cosmic web into clusters, filaments, sheets, and voids, depending on the sign of the eigenvalues of tidal tensor. The reconstructed velocity field nicely shows how the flows are diverging from the centers of voids, and converging onto clusters, while sheets and filaments have flows that are convergent along one and two directions, respectively. We use the reconstructed velocity field and the Zel'dovich approximation to predict the mass density field in the SDSS volume as function of redshift, and find that the mass distribution closely follows the galaxy distribution even on small scales. We find a large-scale bulk flow of about 117km/s in a very large volume, equivalent to a sphere with a radius of ~170Mpc/h, which seems to be produced by the massive structures associated with the SDSS Great Wall. Finally, we discuss potential applications of our reconstruction to study the environmental effects of galaxy formation, to generate initial conditions for simulations of the local Universe, and to constrain cosmological models. The velocity, tidal and density fields in the SDSS volume, specified on a Cartesian grid with a spatial resolution of ~700kpc/h, are available from the authors upon request.Comment: 35 pages, 13 figures, accepted for publication in MNRA

Bilinear R-parity violation with flavor symmetry

Bilinear R-parity violation (BRPV) provides the simplest intrinsically supersymmetric neutrino mass generation scheme. While neutrino mixing parameters can be probed in high energy accelerators, they are unfortunately not predicted by the theory. Here we propose a model based on the discrete flavor symmetry $A_4$ with a single R-parity violating parameter, leading to (i) correct Cabbibo mixing given by the Gatto-Sartori-Tonin formula, and a successful unification-like b-tau mass relation, and (ii) a correlation between the lepton mixing angles $\theta_{13}$ and $\theta_{23}$ in agreement with recent neutrino oscillation data, as well as a (nearly) massless neutrino, leading to absence of neutrinoless double beta decay.Comment: 16 pages, 3 figures. Extended version, as published in JHE