Solar Mikheyev-Smirnov-Wolfenstein Effect with Three Generations of Neutrinos

Under the assumption that the density variation of the electrons can be approximated by an exponential function, the solar Mikheyev-Smirnov-Wolfenstein effect is treated for three generations of neutrinos. The generalized hypergeometric functions that result from the exact solution of this problem are studied in detail, and a method for their numerical evaluation is presented. This analysis plays a central role in the determination of neutrino masses, not only the differences of their squares, under the assumption of universal quark-lepton mixing.Comment: 22 pages, LaTeX, including 2 figure

Gravitational Collapse in Turbulent Molecular Clouds. I. Gasdynamical Turbulence

Observed molecular clouds often appear to have very low star formation efficiencies and lifetimes an order of magnitude longer than their free-fall times. Their support is attributed to the random supersonic motions observed in them. We study the support of molecular clouds against gravitational collapse by supersonic, gas dynamical turbulence using direct numerical simulation. Computations with two different algorithms are compared: a particle-based, Lagrangian method (SPH), and a grid-based, Eulerian, second-order method (ZEUS). The effects of both algorithm and resolution can be studied with this method. We find that, under typical molecular cloud conditions, global collapse can indeed be prevented, but density enhancements caused by strong shocks nevertheless become gravitationally unstable and collapse into dense cores and, presumably, stars. The occurance and efficiency of local collapse decreases as the driving wave length decreases and the driving strength increases. It appears that local collapse can only be prevented entirely with unrealistically short wave length driving, but observed core formation rates can be reproduced with more realistic driving. At high collapse rates, cores are formed on short time scales in coherent structures with high efficiency, while at low collapse rates they are scattered randomly throughout the region and exhibit considerable age spread. We suggest that this naturally explains the observed distinction between isolated and clustered star formation.Comment: Minor revisions in response to referee, thirteen figures, accepted to Astrophys.

'I-I' and 'I-me' : Transposing Buber's interpersonal attitudes to the intrapersonal plane

Hermans' polyphonic model of the self proposes that dialogical relationships can be established between multiple I-positions1 (e.g., Hermans, 2001a). There have been few attempts, however, to explicitly characterize the forms that these intrapersonal relationships may take. Drawing on Buber's (1958) distinction between the 'I-Thou' and 'I-It' attitude, it is proposed that intrapersonal relationships can take one of two forms: an 'I-I' form, in which one I-position encounters and confirms another I-position in its uniqueness and wholeness; and an 'I-Me' form, in which one I-position experiences another I-position in a detached and objectifying way. This article argues that this I-Me form of intrapersonal relating is associated with psychological distress, and that this is so for a number of reasons: Most notably, because an individual who objectifies and subjugates certain I-position cannot reconnect with more central I-positions when dominance reversal (Hermans, 2001a) takes place. On this basis, it is suggested that a key role of the therapeutic process is to help clients become more able to experience moments of I-I intrapersonal encounter, and it is argued that this requires the therapist to confirm the client both as a whole and in terms of each of his or her different voices

Looking for magnetic monopoles at LHC with diphoton events

Magnetic monopoles have been a subject of interest since Dirac established the relation between the existence of monopoles and charge quantization. The intense experimental search carried thus far has not met with success. The Large Hadron Collider is reaching energies never achieved before allowing the search for exotic particles in the TeV mass range. In a continuing effort to discover these rare particles we propose here other ways to detect them. We study the observability of monopoles and monopolium, a monopole-antimonopole bound state, at the Large Hadron Collider in the $\gamma \gamma$ channel for monopole masses in the range 500-1000 GeV. We conclude that LHC is an ideal machine to discover monopoles with masses below 1 TeV at present running energies and with 5 fb$^{-1}$ of integrated luminosity.Comment: This manuscript contains information appeared in Looking for magnetic monopoles at LHC, arXiv:1104.0218 [hep-ph] and Monopolium detection at the LHC.,arXiv:1107.3684 [hep-ph] by the same authors, rewritten for joint publication in The European Physica Journal Plus. 26 pages, 22 figure

Effective suppression of Dengue fever virus in mosquito cell cultures using retroviral transduction of hammerhead ribozymes targeting the viral genome

Outbreaks of Dengue impose a heavy economic burden on developing countries in terms of vector control and human morbidity. Effective vaccines against all four serotypes of Dengue are in development, but population replacement with transgenic vectors unable to transmit the virus might ultimately prove to be an effective approach to disease suppression, or even eradication. A key element of the refractory transgenic vector approach is the development of transgenes that effectively prohibit viral transmission. In this report we test the effectiveness of several hammerhead ribozymes for suppressing DENV in lentivirus-transduced mosquito cells in an attempt to mimic the transgenic use of these effector molecules in mosquitoes. A lentivirus vector that expresses these ribozymes as a fusion RNA molecule using an Ae. aegypti tRNAval promoter and terminating with a 60A tail insures optimal expression, localization, and activity of the hammerhead ribozyme against the DENV genome. Among the 14 hammerhead ribozymes we designed to attack the DENV-2 NGC genome, several appear to be relatively effective in reducing virus production from transduced cells by as much as 2 logs. Among the sequences targeted are 10 that are conserved among all DENV serotype 2 strains. Our results confirm that hammerhead ribozymes can be effective in suppressing DENV in a transgenic approach, and provide an alternative or supplementary approach to proposed siRNA strategies for DENV suppression in transgenic mosquitoes

RNAi for Treating Hepatitis B Viral Infection

Chronic hepatitis B virus (HBV) infection is one of the leading causes of liver cirrhosis and hepatocellular carcinoma (HCC). Current treatment strategies of HBV infection including the use of interferon (IFN)-α and nucleotide analogues such as lamivudine and adefovir have met with only partial success. Therefore, it is necessary to develop more effective antiviral therapies that can clear HBV infection with fewer side effects. RNA interference (RNAi), by which a small interfering RNA (siRNA) induces the gene silence at a post-transcriptional level, has the potential of treating HBV infection. The successful use of chemically synthesized siRNA, endogenous expression of small hairpin RNA (shRNA) or microRNA (miRNA) to silence the target gene make this technology towards a potentially rational therapeutics for HBV infection. However, several challenges including poor siRNA stability, inefficient cellular uptake, widespread biodistribution and non-specific effects need to be overcome. In this review, we discuss several strategies for improving the anti-HBV therapeutic efficacy of siRNAs, while avoiding their off-target effects and immunostimulation. There is an in-depth discussion on the (1) mechanisms of RNAi, (2) methods for siRNA/shRNA production, (3) barriers to RNAi-based therapies, and (4) delivery strategies of siRNA for treating HBV infection

Photoproduction of J/psi and of high mass e+e- in ultra-peripheral Au+Au collisions at sqrt(s_NN) = 200 GeV

We present the first measurement of photoproduction of J/psi and of two-photon production of high-mass e+e- pairs in electromagnetic (or ultra-peripheral) nucleus-nucleus interactions, using Au+Au data at sqrt(s_NN) = 200 GeV. The events are tagged with forward neutrons emitted following Coulomb excitation of one or both Au^{star} nuclei. The event sample consists of 28 events with m_{e+e-} > 2 GeV/c^2 with zero like-sign background. The measured cross sections at midrapidity of d\sigma / dy (J/psi + Xn, y=0) = 76 +/- 33 (stat) +/- 11 (syst) micro b and d^2\sigma/dm dy (e^+e^- + Xn, y=0) = 86 +/- 23 (stat) +/- 16 (syst) micro b/(GeV/c^2) for m_{e+e-} \in [2.0,2.8] GeV/c^2 are consistent with various theoretical predictions.Comment: 345 authors from 52 institutions, 20 pages, 4 figures, 3 tables. Submitted to Physics Letters B. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.htm

HERA Collider Physics

HERA, the first electron-proton collider, has been delivering luminosity since 1992. It is the natural extension of an impressive series of fixed-target lepton-nucleon scattering experiments. The increase of a factor ten in center-of-mass energy over that available for fixed-target experiments has allowed the discovery of several important results, such as the large number of slow partons in the proton, and the sizeable diffractive cross section at large $Q^2$. Recent data point to a possible deviation from Standard Model expectations at very high $Q^2$, highlighting the physics potential of HERA for new effects. The HERA program is currently in a transition period. The first six years of data taking have primarily elucidated the structure of the proton, allowed detailed QCD studies and had a strong impact on the understanding of QCD dynamics. The coming years will bring the era of electroweak studies and high $Q^2$ measurements. This is therefore an appropriate juncture at which to review HERA results.Comment: 351 pages, 154 figures, submitted to Reviews of Modern Physic