Development of a low-cost, electricity-generating Rankine cycle, alcohol-fuelled cooking stove for rural communities

This article describes a novel design and construction of a helical tube flash boiler that uses a 2kW nominal methylated spirit burner to heat an approximately 2.5m long coil of copper pipe fed by a nominal 8 bar electrically operated solenoid water pump. The final embodiment is for superheated steam to be converted to electricity and the waste exit heat from the generator used either for cooking or for ethanol pro duction for low-income families in developing countries. The performance of the flash boiler has been evaluated experimentally based on the well-known “Direct-Method”; by carefully measuring both the flow of the fuel and the steam. It found that the pressure inside the pipe can reach up to 7.4 bar and the temperature of the steam released by the flashing process can reach 255°C utilising a low-cost water pump. The research results prese nted in this paper demonstrate that flash boiler stove has a great potential for generating high-temperature steam for developing a low-cost cooking stove

The Influence of Heat Input Ratio on Electrical Power Output of a Dual-Core Travelling-Wave Thermoacoustic Engine

This paper presents an analytical and experimental investigation of an electricity generator that employs a two-stage looped tube travellin -wave thermoacoustic prime-mover to deliver acoustic power from heat energy, a loudspeaker to extract electricity from sound energy and a tuning stub to compensate the changes in the acoustic field within the engine to enable close to travelling wave operation at the loudspeaker. Furthermore, the paper explains how to enhance the output power utilizing different heat input ratios through the engine cores. A well-known thermoacoustic design tool called Delta EC is used to simulate the wave propagation through the different parts of the system. The electrical power predicted from the low-cost prototype was 24.4 W acoustic power which confirms the potential for developing low-cost thermoacoustic electricity generator for heat recov ery from low-grade heat sources. The electrical power can be increased to 31.3 W using different heating power percentages through the two units. The verified experimental data shows good agreement with DeltaEC results

Analysis and comparison of nonlinear tree height prediction strategies for Douglas-fir forests

Using an extensive Douglas-fir data set from southwest Oregon, we examined the (1) performance and suitability of selected prediction strategies, (2) contribution of relative position and stand-density measures in improving tree height (h) prediction values, and (3) effect of different subsampling designs to fill in missing h values in a new stand using a regional nonlinear model. Nonlinear mixed-effects models (NMEM) substantially improved the accuracy and precision of height prediction over the conventional nonlinear fixed-effects model (NFEM) that assumes the observations are independent, particularly when a few trees are subsampled for height. The predictive performance of a correction factor on a NFEM with relative position and stand-density measures was comparable to that of a NMEM when four or more trees were subsampled for height. When two or more heights were randomly subsampled, the NMEM efficiently explained the differences in the height–diameter relationship because of the variations in relative position of trees and stand density without having to incorporate them into the model. When only one height was subsampled, selecting the largest diameter tree in the stand would result in a lower predicted root mean square error (RMSE) than randomly selecting the height, regardless of the model form or fitting strategy used.A` l’aide d’une banque de donne´es exhaustive sur le sapin Douglas du sud-ouest de l’Oregon, nous avons examine ´ (1) la performance et la pertinence des strate´gies de pre´diction se´lectionne´es, (2) la contribution de la position relative de l’arbre et de la densite´ du peuplement pour ame´liorer la pre´diction de la hauteur des arbres et (3) l’effet de diffe´rents dispositifs d’e´chantillonnage pour imputer la hauteur manquante dans un nouveau peuplement a` l’aide d’un mode`le non line´aire re´gional. Les mode`les non line´aires a` effets mixtes (MNLEM) ame´liorent substantiellement l’exactitude et la pre´cision des pre´dictions de la hauteur comparativement au mode`le non line´aire a` effets fixes conventionnel (MNLEF). Ce dernier suppose que les observations sont inde´pendantes, particulie`rement lorsque peu d’arbres sont e´chantillonne´s pour e´valuer la hauteur. La performance pre´dictive d’un facteur de correction pour le MNLEF base´ sur la mesure de la position relative de l’arbre et de la densite´ du peuplement est comparable a` celle du MNLEM lorsque quatre arbres ou plus sont e´chantillonne´s pour e´valuer la hauteur. Lorsque deux hauteurs ou plus sont e´chantillonne´es ale´atoirement, le MNLEM explique efficacement les diffe´rences dans la relation hauteur-diame`tre dues aux variations de la position relative des arbres et de la densite´ sans avoir a` les incorporer formellement dans le mode`le. Lorsqu’une seule hauteur est e´chantillonne´e, le choix du plus gros arbre dans le peuplement pourrait entraıˆner une erreur de pre´diction plus faible que lorsque la hauteur est se´lectionne´e au hasard, peu importe la forme du mode`le ou la strate´gie d’ajustement utilise´e

A key to the literature on forest growth and yield in the Pacific Northwest, 1910-1981

Tables are presented that summarize 108 published articles on forest growth and yield in the Pacific Northwest. Each table describes the form of the information presented, the species to which the information is applicable, the data sources used to develop the information, the data needed to predict growth and yield, and the form of the predicted data

Assessing the capacity of local ecosystems to meet industrial demand for ecosystem services

Despite the importance of ecosystems, engineering activities continue to ignore or greatly undervalue their role. Consequently, engineered systems often overshoot nature's capacity to support them, causing ecological degradation. Such systems tend to be inherently unsustainable, and they often fail to benefit from nature's ability to provide essential goods and services. This work explores the idea of including ecosystems in chemical processes, and assesses whether such a techno-ecological synergistic system can operate within ecological constraints. The demand for ecosystem services is quantified by emissions and resources used, while the supply is provided by ecosystems on the manufacturing site. Application to a biodiesel manufacturing site demonstrates that ecosystems can be economically and environmentally superior to conventional technologies for making progress toward zero emissions and net positive impact manufacturing. These results highlight the need for shifting the paradigm of engineering from that of dominating nature to embracing nature and respecting its limits

Mathematically gifted and talented learners: Theory and practice

This is an Author's Accepted Manuscript of an article published in International Journal of Mathematical Education in Science and Technology, 40(2), 213-228, 2009, copyright Taylor & Francis, available online at: http://www.tandfonline.com/10.1080/00207390802566907.There is growing recognition of the special needs of mathematically gifted learners. This article reviews policy developments and current research and theory on giftedness in mathematics. It includes a discussion of the nature of mathematical ability as well as the factors that make up giftedness in mathematics. The article is set in the context of current developments in Mathematics Education and Gifted Education in the UK and their implications for Science and Technology. It argues that early identification and appropriate provision for younger mathematically promising pupils capitalizes on an intellectual resource which could provide future mathematicans as well as specialists in Science or Technology. Drawing on a Vygotskian framework, it is suggested that the mathematically gifted require appropriate cognitive challenges as well as attitudinally and motivationally enhancing experiences. In the second half of this article we report on an initiative in which we worked with teachers to identify mathematically gifted pupils and to provide effective enrichment support for them, in a number of London Local Authorities. A number of significant issues are raised relating to the identification of mathematical talent, enrichment provision for students and teachers’ professional development

Multi-centre parallel arm randomised controlled trial to assess the effectiveness and cost-effectiveness of a group-based cognitive behavioural approach to managing fatigue in people with multiple sclerosis

Abstract (provisional) Background Fatigue is one of the most commonly reported and debilitating symptoms of multiple sclerosis (MS); approximately two-thirds of people with MS consider it to be one of their three most troubling symptoms. It may limit or prevent participation in everyday activities, work, leisure, and social pursuits, reduce psychological well-being and is one of the key precipitants of early retirement. Energy effectiveness approaches have been shown to be effective in reducing MS-fatigue, increasing self-efficacy and improving quality of life. Cognitive behavioural approaches have been found to be effective for managing fatigue in other conditions, such as chronic fatigue syndrome, and more recently, in MS. The aim of this pragmatic trial is to evaluate the clinical and cost-effectiveness of a recently developed group-based fatigue management intervention (that blends cognitive behavioural and energy effectiveness approaches) compared with current local practice. Methods This is a multi-centre parallel arm block-randomised controlled trial (RCT) of a six session group-based fatigue management intervention, delivered by health professionals, compared with current local practice. 180 consenting adults with a confirmed diagnosis of MS and significant fatigue levels, recruited via secondary/primary care or newsletters/websites, will be randomised to receive the fatigue management intervention or current local practice. An economic evaluation will be undertaken alongside the trial. Primary outcomes are fatigue severity, self-efficacy and disease-specific quality of life. Secondary outcomes include fatigue impact, general quality of life, mood, activity patterns, and cost-effectiveness. Outcomes in those receiving the fatigue management intervention will be measured 1 week prior to, and 1, 4, and 12 months after the intervention (and at equivalent times in those receiving current local practice). A qualitative component will examine what aspects of the fatigue management intervention participants found helpful/unhelpful and barriers to change. Discussion This trial is the fourth stage of a research programme that has followed the Medical Research Council guidance for developing and evaluating complex interventions. What makes the intervention unique is that it blends cognitive behavioural and energy effectiveness approaches. A potential strength of the intervention is that it could be integrated into existing service delivery models as it has been designed to be delivered by staff already working with people with MS. Service users will be involved throughout this research. Trial registration: Current Controlled Trials ISRCTN7651747

Synthesis of freestanding HfO2 nanostructures

Two new methods for synthesizing nanostructured HfO2 have been developed. The first method entails exposing HfTe2 powders to air. This simple process resulted in the formation of nanometer scale crystallites of HfO2. The second method involved a two-step heating process by which macroscopic, freestanding nanosheets of HfO2 were formed as a byproduct during the synthesis of HfTe2. These highly two-dimensional sheets had side lengths measuring up to several millimeters and were stable enough to be manipulated with tweezers and other instruments. The thickness of the sheets ranged from a few to a few hundred nanometers. The thinnest sheets appeared transparent when viewed in a scanning electron microscope. It was found that the presence of Mn enhanced the formation of HfO2 by exposure to ambient conditions and was necessary for the formation of the large scale nanosheets. These results present new routes to create freestanding nanostructured hafnium dioxide

Bcl-2 and β1-integrin predict survival in a tissue microarray of small cell lung cancer.

INTRODUCTION: Survival in small cell lung cancer (SCLC) is limited by the development of chemoresistance. Factors associated with chemoresistance in vitro have been difficult to validate in vivo. Both Bcl-2 and β(1)-integrin have been identified as in vitro chemoresistance factors in SCLC but their importance in patients remains uncertain. Tissue microarrays (TMAs) are useful to validate biomarkers but no large TMA exists for SCLC. We designed an SCLC TMA to study potential biomarkers of prognosis and then used it to clarify the role of both Bcl-2 and β(1)-integrin in SCLC. METHODS: A TMA was constructed consisting of 184 cases of SCLC and stained for expression of Bcl-2 and β(1)-integrin. The slides were scored and the role of the proteins in survival was determined using Cox regression analysis. A meta-analysis of the role of Bcl-2 expression in SCLC prognosis was performed based on published results. RESULTS: Both proteins were expressed at high levels in the SCLC cases. For Bcl-2 (n=140), the hazard ratio for death if the staining was weak in intensity was 0.55 (0.33-0.94, P=0.03) and for β(1)-integrin (n=151) was 0.60 (0.39-0.92, P=0.02). The meta-analysis showed an overall hazard ratio for low expression of Bcl-2 of 0.91(0.74-1.09). CONCLUSIONS: Both Bcl-2 and β(1)-integrin are independent prognostic factors in SCLC in this cohort although further validation is required to confirm their importance. A TMA of SCLC cases is feasible but challenging and an important tool for biomarker validation

De novo variants of NR4A2 are associated with neurodevelopmental disorder and epilepsy

Purpose This study characterizes the clinical and genetic features of nine unrelated patients with de novo variants in the NR4A2 gene. Methods Variants were identified and de novo origins were confirmed through trio exome sequencing in all but one patient. Targeted RNA sequencing was performed for one variant to confirm its splicing effect. Independent discoveries were shared through GeneMatcher. Results Missense and loss-of-function variants in NR4A2 were identified in patients from eight unrelated families. One patient carried a larger deletion including adjacent genes. The cases presented with developmental delay, hypotonia (six cases), and epilepsy (six cases). De novo status was confirmed for eight patients. One variant was demonstrated to affect splicing and result in expression of abnormal transcripts likely subject to nonsense-mediated decay. Conclusion Our study underscores the importance of NR4A2 as a disease gene for neurodevelopmental disorders and epilepsy. The identified variants are likely causative of the seizures and additional developmental phenotypes in these patients