Differential Input from the Amygdaloid Body to the Ventromedial Hypothalamic Nucleus in the Rat

Differential amygdaloid afferents to anterior dorsal, anterior ventral, posterior dorsal and posterior ventral subdivisions of the ventromedial hypothalamic nucleus (VMH) were studied by means of retrograde transport of horseradish peroxidase (HRP). Injections of tracer confined to the VMH subdivisions mentioned, and enhancement of tracer uptake and transport were achieved by iontophoretic delivery of an HRP solution containing poly-L-α-ornithine. It was shown that the medial, central, basolateral, basomedial, lateroposterior and intercalated nuclei of the amygdala constitute afferent input sources to the ventromedial nucleus in a topographic pattern related to the various subdivisions of the VMH. This topographically organized amygdala-VMH projection is discussed against the background of the functional role that both amygdala and VMH play in the control of feeding, apart from various other autonomous functions that both brain centers are known to be concerned with.

かつおだし摂取のマウスの情動行動及び脳内パルブアルブミン陽性ニューロンに及ぼす影響

富山大学・富生命博甲第88号・Jargalsaikhan Undarmaa・2017/03/23Nutritional Neuroscience,Published online:21 Jul 2016,1-16,doi:10.1080/1028415X.2016.1208429に掲載富山大学201

Thermal stress induces glycolytic beige fat formation via a myogenic state.

Environmental cues profoundly affect cellular plasticity in multicellular organisms. For instance, exercise promotes a glycolytic-to-oxidative fibre-type switch in skeletal muscle, and cold acclimation induces beige adipocyte biogenesis in adipose tissue. However, the molecular mechanisms by which physiological or pathological cues evoke developmental plasticity remain incompletely understood. Here we report a type of beige adipocyte that has a critical role in chronic cold adaptation in the absence of β-adrenergic receptor signalling. This beige fat is distinct from conventional beige fat with respect to developmental origin and regulation, and displays enhanced glucose oxidation. We therefore refer to it as glycolytic beige fat. Mechanistically, we identify GA-binding protein α as a regulator of glycolytic beige adipocyte differentiation through a myogenic intermediate. Our study reveals a non-canonical adaptive mechanism by which thermal stress induces progenitor cell plasticity and recruits a distinct form of thermogenic cell that is required for energy homeostasis and survival

迅速なヘビ検出におけるサル視床枕の役割に関する神経生理学的研究

富山大学・富生命博甲第67号・Le Van Quan・2014/09/26Pulvinar neurons reveal neurobiological evidence of past selection for rapid detection of snakes. Proceedings of the National Academy of Sciences of the United States of America,2013,110(47),19000-19005,doi:10.1073/pnas.1312648110に掲載。出版社版はhttp://www.pnas.org/content/110/47/19000（オープンアクセス）富山大

A category-specific response to animals in the right human amygdala

The amygdala is important in emotion, but it remains unknown whether it is specialized for certain stimulus categories. We analyzed responses recorded from 489 single neurons in the amygdalae of 41 neurosurgical patients and found a categorical selectivity for pictures of animals in the right amygdala. This selectivity appeared to be independent of emotional valence or arousal and may reflect the importance that animals held throughout our evolutionary past

注意開放に関連したラット上丘ニューロンの応答性

富山大学・富生命博甲第66号・Nguyen Hoang Ngan・2014/09/26Frontiers in Integrative Neuroscience,2015,9:9,DOI: 10.3389/fnint.2015.00009に掲載。出版社版はhttp://journal.frontiersin.org/article/10.3389/fnint.2015.00009/full（オープンアクセス）富山大

Brain Cortical Mapping by Simultaneous Recording of Functional Near Infrared Spectroscopy and Electroencephalograms from the Whole Brain During Right Median Nerve Stimulation

To investigate relationships between hemodynamic responses and neural activities in the somatosensory cortices, hemodynamic responses by near infrared spectroscopy (NIRS) and electroencephalograms (EEGs) were recorded simultaneously while subjects received electrical stimulation in the right median nerve. The statistical significance of the hemodynamic responses was evaluated by a general linear model (GLM) with the boxcar design matrix convoluted with Gaussian function. The resulting NIRS and EEGs data were stereotaxically superimposed on the reconstructed brain of each subject. The NIRS data indicated that changes in oxy-hemoglobin concentration increased at the contralateral primary somatosensory (SI) area; responses then spread to the more posterior and ipsilateral somatosensory areas. The EEG data indicated that positive somatosensory evoked potentials peaking at 22 ms latency (P22) were recorded from the contralateral SI area. Comparison of these two sets of data indicated that the distance between the dipoles of P22 and NIRS channels with maximum hemodynamic responses was less than 10 mm, and that the two topographical maps of hemodynamic responses and current source density of P22 were significantly correlated. Furthermore, when onset of the boxcar function was delayed 5–15 s (onset delay), hemodynamic responses in the bilateral parietal association cortices posterior to the SI were more strongly correlated to electrical stimulation. This suggests that GLM analysis with onset delay could reveal the temporal ordering of neural activation in the hierarchical somatosensory pathway, consistent with the neurophysiological data. The present results suggest that simultaneous NIRS and EEG recording is useful for correlating hemodynamic responses to neural activity

Comparative Anatomical Analyses of the Forearm Muscles of Cebus libidinosus (Rylands et al. 2000): Manipulatory Behavior and Tool Use

The present study describes the flexor and extensor muscles in Cebus libidinosus' forearm and compares them with those from humans, chimpanzees and baboons. The data is presented in quantitative anatomical indices for similarity. The capuchin forearm muscles showed important similarities with chimpanzees and humans, particularly those that act on thumb motion and allow certain degree of independence from other hand structures, even though their configuration does not enable a true opposable thumb. The characteristics of Cebus' forearm muscles corroborate the evolutionary convergence towards an adaptive behavior (tool use) between Cebus genus and apes