107 research outputs found
The receptor for advanced glycation end products and risk of peripheral arterial disease, amputation or death in type 2 diabetes: a population-based cohort study
Therapeutic targeting of cathepsin C::from pathophysiology to treatment
Cathepsin C (CatC) is a highly conserved tetrameric lysosomal cysteine dipeptidyl aminopeptidase. The best characterized physiological function of CatC is the activation of pro-inflammatory granule-associated serine proteases. These proteases are synthesized as inactive zymogens containing an N-terminal pro-dipeptide, which maintains the zymogen in its inactive conformation and prevents premature activation, which is potentially toxic to the cell. The activation of serine protease zymogens occurs through cleavage of the N-terminal dipeptide by CatC during cell maturation in the bone marrow. In vivo data suggest that pharmacological inhibition of pro-inflammatory serine proteases would suppress or attenuate deleterious effects of inflammatory/auto-immune disorders mediated by these proteases. The pathological deficiency in CatC is associated with Papillon-Lefèvre syndrome. The patients however do not present marked immunodeficiency despite the absence of active serine proteases in immune defense cells. Hence, the transitory pharmacological blockade of CatC activity in the precursor cells of the bone marrow may represent an attractive therapeutic strategy to regulate activity of serine proteases in inflammatory and immunologic conditions. A variety of CatC inhibitors have been developed both by pharmaceutical companies and academic investigators, some of which are currently being employed and evaluated in preclinical/clinical trials
Apocalypsis revelata in qua deteguntur areana quae ibi praedicta sunt et hactenus recondita latuerunt. Opus Emanuelis Swedenborg cujus editio princeps exiit Amstelodami, 1766 ...
Mode of access: Internet."Editoris pracfatio" signed: Samuel H. Worcester
Apocalypsis explicata secundum sensum spiritualem ubi revelantur areana quae ibi praedicta et hactenus recondita fuerunt. Opus posthumum Emanuelis Swedenborgii ad fidem editionis photolithographicae 1870 Holmiae excusae ...
Vol. 6: Index rerum tum index locorum Scrupturae Sacrae adornati ab editore.Mode of access: Internet."Editoris oraefatio" signed: Samuel H. Worcester
Sapientia angelica de divino amore et de divina sapientia.
Mode of access: Internet.Ed. by S.H. Worcester.With this is bound his Sapientia angelica de divina providentia. 1899
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