10 research outputs found
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Synthetic cytokine circuits that drive T cells into immune-excluded tumors
- Author
- Publication venue
- eScholarship, University of California
- Publication date
- 16/12/2022
- Field of study
Chimeric antigen receptor (CAR) T cells are ineffective against solid tumors with immunosuppressive microenvironments. To overcome suppression, we engineered circuits in which tumor-specific synNotch receptors locally induce production of the cytokine IL-2. These circuits potently enhance CAR T cell infiltration and clearance of immune-excluded tumors, without systemic toxicity. The most effective IL-2 induction circuit acts in an autocrine and T cell receptor (TCR)- or CAR-independent manner, bypassing suppression mechanisms including consumption of IL-2 or inhibition of TCR signaling. These engineered cells establish a foothold in the target tumors, with synthetic Notch-induced IL-2 production enabling initiation of CAR-mediated T cell expansion and cell killing. Thus, it is possible to reconstitute synthetic T cell circuits that activate the outputs ultimately required for an antitumor response, but in a manner that evades key points of tumor suppression
Effect of Hydrogenation on the Chemical Composition of Canola Oil
- Author
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Radiofrequency oxygen plasma treatment of pyrolytic graphite electrode surfaces
- Author
- Angerstein-Kozlowska H.
- Angerstein-Kozlowska H.
- Berthou H.
- Biller J. E.
- Blaedel W. J.
- Blaisdell B. E.
- Blurton K. F.
- Boehm P.
- Boehm P.
- Carhart R. E.
- Carlson T. A.
- Dijkstra E. W.
- Dromey R. G.
- Elliot C. M.
- Epstein B. D.
- Evans J. F.
- Firth B. E.
- Garten V. A
- Hammer C. G.
- Hawkrldge F.
- Hertz H. S.
- Jellum E.
- John F. Evans
- Karasek F. W.
- Mamantov G.
- Mattson J. S.
- Merrifield R. B.
- Nau H.
- Nau H.
- Oldfield L. F.
- Pilla A. A.
- Purl B. R.
- Randin J. P.
- Randin J. P.
- Sheehan J. C.
- Smith D. H.
- Stokke O.
- Sweeley C. C.
- Taylor R. J.
- Theodore. Kuwana
- Thomas J. M.
- Thompson J. A.
- Watkins B. F.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
DESEGREGATION: VOLUNTARY OR MANDATORY?
- Author
- Armor David
- Ausubel David P.
- Bernard Viola
- Campbell J. D.
- Carrigan Patricia
- Cheslar Mark A.
- Coleman James S.
- Coles Robert
- Crain Robert
- Denmark Florence
- Dimond Paul R.
- Fox David J.
- Frankel Edward
- Freeman Howard E.
- Gottlieb David
- Katz Irwin
- Lundberg George A.
- Mahan Thomas W.
- McPartland James
- Milner Esther
- Nancy H. St. John
- Pettigrew Thomas F.
- Porter Judith
- Purl Mabel C.
- Ransford H. Edward.
- Singer Dorothy
- St. John Nancy
- Sullivan Neil
- Teele James E.
- Useem Betsy L.
- Veroff Joseph
- Webster Staten W.
- Weinberg Meyer
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Comparison of methods to assess surface acidic groups on activated carbons
- Author
- Ahsan T
- Ahsan T.
- Bansal R. C.
- Boehm P.
- Cobb K A
- Department of Chemical Engineering and Materials Science
- Dong S.
- Dorris G. M.
- Havard D. C.
- Huang X.
- Hunter R. J.
- Ignasik B. S.
- Jacek. Jagiello
- JagieUo J.
- James A. Schwarz
- Jorgenson J. W.
- Jorgenson J. W.
- Kiselev A. V.
- Kiselev A. V.
- Lauer H.
- Lee C. S.
- Lee C. S.
- Lee C. S.
- McCormick R. M.
- Nakayama Y.
- Nelson R. J.
- Noh J. S.
- Purl B. R.
- Richard E.
- Saint-Flour C.
- Schultz J.
- Skoog B.
- Sldql M.
- Smlsek M.
- Teresa J. Bandosz
- Tsuda T.
- von Fredersdor H G. G.
- Wallingford R. A.
- Worthington C. C.
- Zawadzki J.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Nonparametric methods in factorial designs
- Author
- A. M. Mathai
- A. Raviv
- D. D. Boos
- D. J. Groggle
- D. Quade
- E. B. Page
- E. Brunner
- E. Brunner
- E. Brunner
- E. Brunner
- E. Brunner
- E. Brunner
- E. Brunner
- E. Brunner
- E. Brunner
- Edgar Brunner
- F. A. Graybill
- F.H. Ruymgaart
- G. A. Mack
- G. E. P. Box
- G. G. KOCH
- G. G. Koch
- G. G. Koch
- G. L. Thompson
- G. L. Thompson
- G. L. Thompson
- G. L. Thompson
- H. H. Lemmer
- J. I. Marden
- J. L. Kepner
- K. L. Mehra
- K. M. Patel
- M. G. Akritas
- M. G. Akritas
- M. G. Akritas
- M. G. Akritas
- M. G. Akritas
- M. G. Akritas
- M. Hollander
- M. L. Puri
- M. L. PURl
- Madan L. Puri
- P. K. Sen
- P. Levy
- R. C Blair
- S. C. Hora
- T. P. Hettmansperger
- U. Munzel
- U. Munzel
- W. C. Rinaman
- W. H. Kruskal
- W. H. Kruskal
- W. H. Kruskal
- W. J. Conover
- W. J. Conover
- Z. Govindarajulu
- Publication venue
- Publication date
- Field of study
Rank Tests, Factorial Designs, Repeated Measures, Unbalanced Designs, Ordered Categorical Data, Count Data,
Alteration of metal release mechanisms in graphite furnace atomizers by chemisorbed oxygen
- Author
- Ag
- Aggett J.
- Beaty M.
- Campbell W. C.
- Department of Chemistry
- Eklund R. H.
- Fuller C. W.
- Fuller C. W.
- Fuller C. W.
- Fuller C. W.
- Gaydon A. G.
- Hart P.
- Holcombe J. A.
- James A. Holcombe
- Johnson D. J.
- Katskov D. A.
- L'vov
- L'vov B. V.
- L'vov B. V.
- Lalne N. R.
- Lussow R. O.
- McLaren J. W.
- Paverl-Fontana S. L.
- Paverl-Fontana S. L.
- Pb
- Purl B. R.
- Regan J.
- Regan J.
- Salmon S. G.
- Salmon S. G.
- Salmon S. G.
- Savltzky A.
- Smets B.
- Stephen G. Salmon
- Sturgeon R. E.
- Tessarl G.
- Tessarl G.
- Torsi G.
- Torsi G.
- Van de Broek W.
- Vastóla F. J.
- Zsakó J.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
6: Desegregation and Minority Group Performance
- Author
- Anderson Louis V
- Archibald David K
- Banks Ronald
- Beker Jerome
- Bowles Samuel
- Campbell Donald T
- Clark Kenneth B
- Clark Kenneth B
- Clark Kenneth B
- Coleman James S
- Conant James B
- Dressler Frank J
- Duncan Otis D
- Fortenberry James H
- Fox David J
- Fox David J
- Fox David J
- Gordon Edmund W
- Hansen Carl F
- Herriott Robert E
- Jessup Dorothy K
- Jonnson Harold A
- Kaplan John
- Katzenmeyer William Gilbert
- Katzman Martin T
- Klineberg Otto
- Laird Mary Alice
- Lockwood Jane Durand
- Mahan Thomas W
- Mahan Thomas W
- Matthai Robert Arthur
- Matzen Stanley Paul
- McCauley Patrick
- McPartland James
- Meketon Betty Field
- Miller Carroll L
- Moriber Leonard
- Nancy H. ST. John
- Peterson RA
- Pettigrew Thomas F
- Public Education Association
- Purl Mabel C
- Radin Norma
- Rock William C
- Rock William C
- Rock William C
- Samuels Ivan G
- Sexton Patricia
- Smith Marshall S
- St. John Nancy H
- St. John Nancy Hoyt
- St. John Nancy Hoyt
- Stetler Henry G
- Stouffer Samuel A
- Sullivan Neil V
- United States Commission on Civil Rights
- Walberg Herbert J
- Weinberg Meyer
- Wessman Alden E
- White Plains Public Schools
- Whiteman Martin
- Wilson Alan B
- Wilson Alan B
- Wolff Max
- Wolman TG
- Publication venue
- 'American Educational Research Association (AERA)'
- Publication date
- Field of study
Urogenital tuberculosis
- Author
- A Ambrosetti
- A Berczeller
- A Beskow
- A Blystad
- A Cuenot
- A Cuenot
- A Dacosta
- A Dimtza
- A Dimtza
- A Dufour
- A Dufour
- A Frisch
- A Gaertner
- A Gütgemann
- A Homb
- A Jacobs
- A Jacobs
- A Jacobs
- A Jacobs
- A Jacobs
- A Jacobs
- A Jacobs
- A Joller
- A Kristenson
- A Ladehoff
- A Lind
- A Lind
- A Lindbom
- A Luzès
- A Maffucci
- A Martin-Laval
- A Martin-Laval
- A Mitchell
- A Mitscierlich
- A Moyaprats
- A Paladino-Blandini
- A Palmlöv
- A Peña
- A Puigvert
- A Puigvert
- A Puigvert
- A Puigvert
- A Péna
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- A Péna
- A Randall
- A Ravich
- A Renander
- A Schatz
- A Socin
- A Sporer
- A Sporer
- A Steinbock
- A Tacxot
- A Troell
- A Wallgren
- A Wallgren
- A Wallgren
- A Wallgren
- A Wallgren
- A Wallnek
- A Weiser
- A Westerborn
- A. S. Griffith
- AC Finlay
- AE Bottie
- AF Read
- AG Karlsson
- AH Baggenstoss
- AI Dodson
- AJ Greenberger
- AL Chute
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- AL Dean
- AP Gorro
- AW Adams
- B Cholzoff
- B Fey
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- B Gayet
- B Snellman
- B Stenström
- B Terruzzi
- BM Fisher
- C Benda
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- C Gelderen
- C Huawitz
- C Hurter
- C Hurwitz
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- C Lahayville
- C Pana
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- CA Coleman
- CA Sthill
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- DW Mackenzie
- E Asshauer
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- E Chauvin
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- E Ljunggren
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- E Ljunggren
- E Ljunggren
- E Ljunggren
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- E Moberg
- E Papin
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- W Peters
- W Staehler
- W Staehler
- W Staehler
- W Steenken Jr.
- W Steenken Jr.
- W Steenken Jr.
- W Szybalski
- WA Moonen
- WA Murray
- WB Tucker
- WB Tucker
- WB Tucker
- WE Dye
- WE Kittredge
- WE Lower
- Wegelin
- WF Braasch
- WF Braasch
- WF Braasch
- WF Braasch
- WF Russell Jr
- WG Townsend
- WH Feldman
- WH Feldman
- WH Feldman
- WH Feldman
- WL Howard
- WM Borthwick
- WM Borthwick
- WM Borthwick
- WM Borthwick
- WM Borthwick
- WM Borthwick
- WP Herbst
- WR Barclay
- WT Munro
- WW Scott
- Y Yaoita
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1959
- Field of study
Entwicklung und klimatische Differenzierung der Laubwaldflora Mitteleuropas im Tertiär
- Author
- Ablaev
- Andrae
- Andreánszky
- Andreánszky
- Andreánszky
- Andreánszky
- Andreánszky
- Andreánszky
- Andreánszky
- Andreánszky
- Andreánszky
- Baas
- Bader
- Baikovskaia
- Baily
- Baranova
- Berger
- Berger
- Berger
- Berry
- Berry
- Berry
- Berry
- Berry
- Berry
- Berry
- Berry
- Bones
- Bourdeau
- Braun
- Bronn
- Brown
- Budancev
- Buell
- Bünning
- Bůžek
- Bůžek
- Bůžek
- Bůžek
- Chandler
- Chandler
- Chandler
- Chandler
- Chandler
- Chandler
- Chaney
- Chaney
- Chapman
- Chapman
- Chochieva
- Chochieva
- Czeczott
- Czeczott
- Czeczott
- Cziffery-Szilagy
- Davis
- Depape
- Depape
- Dieter H. Mai
- Dilcher
- Dolianiti
- Dorf
- Dorofeev
- Dorofeev
- Dorofeev
- Dorofeev
- Dorofeev
- Dorofeev
- Dorofeev
- Eberle
- Ellenberg
- Engelhardt
- Engelhardt
- Engelhardt
- Engelhardt
- Engler
- Ettingshausen
- Fedorov
- Fedorov
- Fischer
- Fosberg
- Frenzel
- Friedrich
- Friedrich
- Fritel
- Fritel
- Fritel
- Fritel
- Fritel
- Gardner
- Givulescu
- Givulescu
- Givulescu
- Givulescu
- Givulescu
- Givulescu
- Givulescu
- Givulescu
- Givulescu
- Gomez-Pompa
- Grangeon
- Gregor
- Gregor
- GÖPpert
- Hajós
- Hanelt
- Hantke
- Hantke
- Hara
- Heer
- Heer
- Heer
- Heinke
- Hirmer
- Horvat
- Hui-Lin
- Hui-Lin
- Hunger
- Hurník
- Iljinskaja
- Jakubovskaja
- Jentys-Szaferowa
- Johnson
- Johnson
- Johnson
- Jung
- Juraskyk
- Jäger
- Jäger
- JÄGer
- Kabanov
- Kanai
- Kedves
- Kilpper
- Kilpper
- Kirchheimer
- Kirchheimer
- Kirchheimer
- Kirchheimer
- Kirchheimer
- Kirchheimer
- Kirchheimer
- Kirchheimer
- Kitanov
- Klotz
- Knapp
- Knobloch
- Knobloch
- Knobloch
- Knobloch
- Knobloch
- Knobloch
- Knobloch
- Knobloch
- Knobloch
- Knobloch
- Knobloch
- Knobloch
- Koch
- Koch
- Kolakovskij
- Kolakovskij
- Kolakovskij
- Kolakovskij
- Kolakovskij
- Kolakovskij
- KovÁTs
- Krutzsch
- Kryshtofovich
- Kryshtofovich
- KrÄUsel
- KrÄUsel
- KrÄUsel
- Kuchler
- Kuyl
- KvaČEk
- KvaČEk
- Lakowitz
- Langeron
- Laurent
- Laurent
- Lavrenko
- Lehner
- Leopold
- Mal
- Mal
- Mal
- Mal
- Mal
- Mal
- Mal
- Mal
- Mal
- Mal
- Mal
- Mal
- Mccormick
- Meijer
- Menzel
- Meusel
- Meusel
- Meusel
- Meusel
- Meusel
- Meusel
- Meyer
- Miki
- Miranda
- Mitchell
- Miyawaki
- Muenscher
- Muller
- Mädler
- Mägdefrau
- Müller-Stoll
- Negru
- Negru
- Nemějc
- Nemějc
- Noirfalise
- Oberdorfer
- Oberdorfer
- Palamarev
- Palamarev
- Palamarev
- Panfilov
- Pax
- Pax
- Petrescu
- Potbury
- Principi
- Purl
- Raniecka-Bobrowska
- Raniecka-Bobrowska
- Rao
- Rasmussen
- Reid
- Reid
- Richards
- Rüffle
- Rüffle
- Safarov
- Safarov
- Saporta
- Saporta
- Saporta
- Saporta
- Schimper
- Schloemer-JäGer
- Schmid
- Schneider
- Schneider
- Schneider
- Schneider
- Schubert
- Schwarzbach
- Schweinfurth
- Scott
- Selli
- Senghas
- Seward
- Shuangxing
- Steyermark
- Straus
- Straus
- Stur
- Sturm
- Suzuki
- Suzuki
- Szafer
- Szafer
- Szafer
- Takhtadjan
- Takhtadjan
- Tanai
- Tanai
- Tanai
- Tanai
- Tanai
- Tanai
- Teichmüller
- Thomson
- Thomson
- Tiffney
- Tralau
- Tralau
- Tsukada
- Unger
- Van Beusekom
- Van Steenis
- Van Steenis
- Van Steenis
- Van Steenis
- Van Steenis
- Vangerow
- Vasiljev
- Vasiljev
- Vent
- Vidal
- Walter
- Walter
- Walther
- Walther
- Wang
- Weber
- Weyland
- Weyland
- Wolfe
- Wolfe
- Wolfe
- Wolfe
- Wolfe
- Wolfe
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/1981
- Field of study