A mutation in exon 7 of the human cytochrome P-4501A1 gene as marker for sensitivity to anti-cancer drugs?

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The development of a prototype intelligent user interface subsystem for NASA's scientific database systems

The National Space Science Data Center (NSSDC) has initiated an Intelligent Data Management (IDM) research effort which has as one of its components the development of an Intelligent User Interface (IUI).The intent of the latter is to develop a friendly and intelligent user interface service that is based on expert systems and natural language processing technologies. The purpose is to support the large number of potential scientific and engineering users presently having need of space and land related research and technical data but who have little or no experience in query languages or understanding of the information content or architecture of the databases involved. This technical memorandum presents prototype Intelligent User Interface Subsystem (IUIS) using the Crustal Dynamics Project Database as a test bed for the implementation of the CRUDDES (Crustal Dynamics Expert System). The knowledge base has more than 200 rules and represents a single application view and the architectural view. Operational performance using CRUDDES has allowed nondatabase users to obtain useful information from the database previously accessible only to an expert database user or the database designer

The crustal dynamics intelligent user interface anthology

The National Space Science Data Center (NSSDC) has initiated an Intelligent Data Management (IDM) research effort which has, as one of its components, the development of an Intelligent User Interface (IUI). The intent of the IUI is to develop a friendly and intelligent user interface service based on expert systems and natural language processing technologies. The purpose of such a service is to support the large number of potential scientific and engineering users that have need of space and land-related research and technical data, but have little or no experience in query languages or understanding of the information content or architecture of the databases of interest. This document presents the design concepts, development approach and evaluation of the performance of a prototype IUI system for the Crustal Dynamics Project Database, which was developed using a microcomputer-based expert system tool (M. 1), the natural language query processor THEMIS, and the graphics software system GSS. The IUI design is based on a multiple view representation of a database from both the user and database perspective, with intelligent processes to translate between the views

Active noise compensation for multichannel magnetocardiography in an unshielded environment

A multichannel high-T/sub c/-SQUID-based heart scanner for unshielded environments is under development, Outside a magnetically shielded room, sensitive SQUID measurements are possible using gradiometers. However, it is difficult to realize large-baseline gradiometers in high-T/sub c/ materials, Therefore, the authors developed two active noise compensation techniques. In the Total Field Compensation technique, a Helmholtz type coil set is placed around the sensors. One magnetometer is used as a zero detector controlling the compensation current through the coil set. For Individual Flux Compensation, the reference signal is sent to the separate SQUIDs (or their flux transformer circuits) to compensate the local environmental noise fluxes, The latter technique was tested on low-T/sub c/ rf-SQUID magnetometers, each sensor set to a field resolution SQUID magnetometers, i.e. 0.1 pT/sub RMS///spl radic/Hz. The authors were able to suppress the environmental disturbances to such an extent that magnetocardiograms could be recorded in an ordinary environment. Here the two suppression techniques are described and experimental results are presente

Binaries discovered by the SPY project. IV, Five single-lined DA double white dwarfs

We present results from our ongoing follow-up observations of double white dwarf binaries detected in the ESO SN Ia Progenitor SurveY (SPY). We discuss our observing strategy and data analysis and present the orbital solutions of five close double white dwarf binaries: HE0320−1917, HE1511−0448, WD0326−273, WD1013−010 and WD1210+140. Their periods range from 0.44 to 3.22 days. In none of these systems we find any spectral lines originating from the companion. This rules out main sequence companions and indicates that the companion white dwarfs are significantly older and cooler than the bright component. Infrared photometry suggests the presence of a cool, helium-rich white dwarf companion in the binary WD 0326−273. We briefly discuss the consequences of our findings for our understanding of the formation and evolution of double white dwarfs

The expanding bipolar shell of the helium nova V445 Puppis

From multi-epoch adaptive optics imaging and integral field unit spectroscopy, we report the discovery of an expanding and narrowly confined bipolar shell surrounding the helium nova V445 Puppis (Nova Puppis 2000). An equatorial dust disc obscures the nova remnant, and the outflow is characterized by a large polar outflow velocity of 6720 +/- 650 km s(-1) and knots moving at even larger velocities of 8450 +/- 570 km s(-1). We derive an expansion parallax distance of 8.2 +/- 0.5 kpc and deduce a pre-outburst luminosity of the underlying binary of log L/L-circle dot = 4.34 +/- 0.36. The derived luminosity suggests that V445 Puppis probably contains a massive white dwarf accreting at high rate from a helium star companion making it part of a population of binary stars that potentially lead to supernova Ia explosions due to accumulation of helium-rich material on the surface of a massive white dwarf

Interference with the Mate-Finding Communication System of the Obliquebanded Leafroller (Lepidoptera: Tortricidae) Using Synthetic Sex Pheromones

Effect of atmospheric permeation with synthetic sex pheromone on the behavior and control of obliquebanded leafroller, Choristoneura rosaceana (Harris), was studied in small and large plots in commercial apple orchards. Synthetic sex pheromone significantly reduced the ability of male moths to locate pheromone-baited traps and tethered females; however, no differences were found among 3 pheromone rates. Location of pheromone dispensers within the tree canopy did not alter the number of males locating pheromone-baited traps and mating tethered females. Obliquebanded leafroller activity was greatest in the upper positions of the tree canopy and no edge effect was observed around perimeters of large disrupted blocks. The presence of gravid feral females, mated tethered females, high larval densities, and fruit damage within large pheromone disrupted blocks indicate obliqubanded leafrollers mate in orchards treated with synthetic sex pheromone. However, fruit damage caused by obliquebanded leafroller larvae was similar in pheromone, pheromone plus insecticide, and insecticide treatment

A search for the hidden population of AM CVn binaries in the Sloan Digital Sky Survey

We present the latest results from a spectroscopic survey designed to uncover the hidden population of AM Canum Venaticorum (AM CVn) binaries in the photometric data base of the Sloan Digital Sky Survey (SDSS). We selected ∼2000 candidates based on their photometric colours, a relatively small sample which is expected to contain the majority of all AM CVn binaries in the SDSS (expected to be ∼50). We present two new candidate AM CVn binaries discovered using this strategy: SDSS J104325.08+563258.1 and SDSS J173047.59+554518.5. We also present spectra of 29 new cataclysmic variables, 23 DQ white dwarfs and 21 DZ white dwarfs discovered in this survey. The survey is now approximately 70 per cent complete, and the discovery of seven new AM CVn binaries indicates a lower space density than previously predicted. From the essentially complete g ≤ 19 sample, we derive an observed space density of (5 ± 3) × 10^(−7) pc^(−3); this is lower than previous estimates by a factor of 3. The sample has been cross-matched with the GALEX All-Sky Imaging Survey data base, and with Data Release 9 of the United Kingdom Infrared Telescope (UKIRT) Infrared Deep Sky Survey (UKIDSS). The addition of UV photometry allows new colour cuts to be applied, reducing the size of our sample to ∼1100 objects. Optimizing our follow-up should allow us to uncover the remaining AM CVn binaries present in the SDSS, providing the larger homogeneous sample required to more reliably estimate their space density

Supersymmetric version of a Gaussian irrotational compressible fluid flow

The Lie point symmetries and corresponding invariant solutions are obtained for a Gaussian, irrotational, compressible fluid flow. A supersymmetric extension of this model is then formulated through the use of a superspace and superfield formalism. The Lie superalgebra of this extended model is determined and a classification of its subalgebras is performed. The method of symmetry reduction is systematically applied in order to derive special classes of invariant solutions of the supersymmetric model. Several new types of algebraic, hyperbolic, multi-solitonic and doubly periodic solutions are obtained in explicit form.Comment: Expanded introduction and added new section on classical Gaussian fluid flow. Included several additional reference

Water Resources Planning and Social Goals: Conceptualization Toward a New Methodology

A modeling concept relating water resource use t