Wave energy system using piezoelectric panel

In this research, we research the characteristics of a new type of wave-power generation system that\ud deducts ocean wave energy to the front part by installing a piezo-electric element on the outside of the existing harbor\ud structure. The wave-power generation system proposed in this research might be applied to a variety of marine structure,\ud which makes it possible to add wave-power generation capacity to the original structural function. Furthermore, it cost\ud relatively less to build multiple generators, which makes its wave-power generation for a bigger launch. Moreover, it\ud might be developed in link with a tourism complex by adopting the wave-power generation system. Accordingly, we\ud analyze the usability of the existing marine structure and characteristics and current research trend in the ocean wave\ud energy retrieval of the wave-power generation system. In addition, in order to review hydrographic characteristics of the\ud proposed system, seen from the result of carrying out 2-D cross-section hydrographic model test, it is confirmed that the\ud maximum wave pressure and voltage increase when in the cases of higher wave and longer period. The result from\ud hydrographic model test indicates that wave-power generation system using piezoelectric element has different\ud generation volume depending upon crushing wave height rather than incidence cycle. It also indicates that the\ud generation volume increase in positive proportion to the size of ocean wave energy

Translational repression of mouse mu opioid receptor expression via leaky scanning

Mu opioid receptor (MOR) expression is under temporal and spatial controls, but expression levels of the MOR gene are relatively low in vivo. In addition to transcriptional regulations, upstream AUGs (uAUGs) and open reading frames (uORFs) profoundly affect the translation of the primary ORF and thus the protein levels in several genes. The 5′-untranslated region (UTR) of mouse MOR mRNA contains three uORFs preceding the MOR main initiation codon. In MOR-fused EGFP or MOR promoter/luciferase reporter constructs, mutating each uAUG individually or in combinations increased MOR transient heterologous expression in neuroblastoma NMB and HEK293 cells significantly. Translation of such constructs increased up to 3-fold without altering the mRNA levels if either the third uAUG or both the second and third AUGs were mutated. Additionally, these uAUG-mediated translational inhibitions were independent of their peptide as confirmed by internal mutation analyses in each uORF. Translational studies indicated that protein syntheses were initiated at these uAUG initiation sites, with the third uAUG initiating the highest translation level. These results support the hypothesis that uORFs in mouse MOR mRNA act as negative regulators through a ribosome leaky scanning mechanism. Such leaky scanning resulted in the suppression of mouse MOR under normal conditions

Reliable Multivalued Conductance States in TaOx, Memristors through Oxygen Plasma-Assisted Electrode Deposition with in Situ-Biased Conductance State Transmission Electron Microscopy Analysis

Transition metal oxide-based memristors have widely been proposed for applications toward artificial synapses. In general, memristors have two or more electrically switchable stable resistance states that device researchers see as an analogue to the ion channels found in biological synapses. The mechanism behind resistive switching in metal oxides has been divided into electrochemical metallization models and valence change models. The stability of the resistance states in the memristor vary widely depending on: oxide material, electrode material, deposition conditions, film thickness, and programming conditions. So far, it has been extremely challenging to obtain reliable memristors with more than two stable multivalued states along with endurances greater than similar to 1000 cycles for each of those states. Using an oxygen plasma-assisted sputter deposition method of noble metal electrodes, we found that the metal-oxide interface could be deposited with substantially lower interface roughness observable at the nanometer scale. This markedly improved device reliability and function, allowing for a demonstration of memristors with four completely distinct levels from similar to 6 x 10(-6) to similar to 4 x 10(-8) S that were tested up to 10(4) cycles per level. Furthermore through a unique in situ transmission electron microscopy study, we were able to verify a redox reaction-type model to be dominant in our samples, leading to the higher degree of electrical state controllability. For solid-state synapse applications, the improvements to electrical properties will lead to simple device structures, with an overall power and area reduction of at least 1000 times when compared to SRAM.11Ysciescopu

Thermal-aware 3D Microarchitectural Floorplanning

Next generation deep submicron processor design will need to take into consideration many performance limiting factors. Flip flops are inserted in order to prevent global wire delay from becoming nonlinear, enabling deeper pipelines and higher clock frequency. The move to 3D ICs will also likely be used to further shorten wirelength. This will cause thermal issues to become a major bottleneck to performance improvement. In this paper we propose a floorplanning algorithm which takes into consideration both thermal issues and profile weighted wirelength using mathematical programming. Our profile-driven objective improves performance by 20% over wirelength-driven. While the thermal-driven objective improves temperature by 24% on average over the profile-driven case

Doubly Coexisting Dark Matter Candidates in an Extended Seesaw Model

We examine how a scenario of coexisting two-particle dark mater can be realized in the extended seesaw model, which we have proposed previously to accommodate small neutrino masses and low scale leptogenesis with an introduction of singlet Majorana neutrino $S$ and singlet scalar $\phi$. We now impose the discrete symmetry $Z_2 \times Z_2^{\prime}$ and introduce new renormalizable interaction terms with a new heavy singlet scalar particle $\Phi$ so as for previously introduced $S$ and $\phi$ to be doubly coexisting dark matter candidates. Depending on the mass spectrum of the two dark matter candidates, the annihilation process either $SS\longrightarrow \phi \phi$ or $\phi\phi\longrightarrow SS$ is of particular interest because the annihilation cross sections for the processes can be so large that the relic abundance of decaying particle should get lowered, which in turn makes the constraints on its parameter space relaxed, compared with the case of one and only one dark matter candidate. We discuss the implications of the dark matter detection through the scattering off the nucleus of the detecting material on our scenarios for dark matter candidates. We also study the implications for the search of invisible Higgs decay at LHC, which may serve as a probe of our scenario for dark matter.Comment: modified to renormalizable model

The role of day care for teenage mothers in a public school

Society stresses that teenage mothers should be helped to finish their high school education. However, their schooling can become a reality only if accompanied by child care.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44266/1/10566_2005_Article_BF01132194.pd

Evidence of the neuron-restrictive silencer factor (NRSF) interaction with Sp3 and its synergic repression to the mu opioid receptor (MOR) gene

Previously, we reported that the neuron-restrictive silencer element (NRSE) of mu opioid receptor (MOR) functions as a critical regulator to repress the MOR transcription in specific neuronal cells, depending on neuron-restriction silence factor (NRSF) expression levels [C.S.Kim, C.K.Hwang, H.S.Choi, K.Y.Song, P.Y.Law, L.N.Wei and H.H.Loh (2004) J. Biol. Chem., 279, 46464–46473]. Herein, we identify a conserved GC sequence next to NRSE region in the mouse MOR gene. The inhibition of Sp family factors binding to this GC box by mithramycin A led to a significant increase in the endogenous MOR transcription. In the co-immunoprecipitation experiment, NRSF interacted with the full-length Sp3 factor, but not with Sp1 or two short Sp3 isoforms. The sequence specific and functional binding by Sp3 at this GC box was confirmed by in vitro gel-shift assays using either in vitro translated proteins or nuclear extract, and by in vivo chromatin immunoprecipitation assays. Transient transfection assays showed that Sp3-binding site of the MOR gene is a functionally synergic repressor element with NRSE in NS20Y cells, but not in the NRSF negative PC12 cells. The results suggest that the synergic interaction between NRSF and Sp3 is required to negatively regulate MOR gene transcription and that transcription of MOR gene would be governed by the context of available transcription factors rather than by a master regulator

Impact of COVID-19 on medical education: Introducinghomo digitalis

Purpose To determine how members of the Societe Internationale d'Urologie (SIU) are continuing their education in the time of COVID-19. Methods A survey was disseminated amongst SIU members worldwide by email. Results were analyzed to examine the influence of age, practice region and settings on continuing medical education (CME) of the respondents. Results In total, 2494 respondents completed the survey. Internet searching was the most common method of CME (76%; allps = 2 platforms, with approximately 10% of the respondents using up to 5 different platforms. Urologists < 40 years old were more likely to use online literature (69%), podcasts/AV media (38%), online CME courses/webinars (40%), and social media (39%). There were regional variations in the CME modality used but no significant difference in the number of methods by region. There was no significant difference in responses between urologists in academic/public hospitals or private practice. Conclusion During COVID-19, urologists have used web-based learning for their CME. Internet learning and literature were the top frequently cited learning methods. Younger urologists are more likely to use all forms of digital learning methods, while older urologists prefer fewer methods

Welfare Impact of Carbon Dioxide Euthanasia on Laboratory Mice and Rats : A Systematic Review

Background: There has been increased concern about the suitability of CO as a method for euthanasia of laboratory mice and rats, including the potential discomfort, pain or distress that animals may experience prior to loss of consciousness; time to loss of consciousness; best methods for use of CO; and the availability of better alternatives. These discussions have been useful in providing new information, but have resulted in significant confusion regarding the acceptability of CO for rodent euthanasia. In some cases, researchers and veterinarians have become uncertain as to which techniques to recommend or use for euthanasia of laboratory mice and rats. Methods: The International Association of Colleges of Laboratory Animal Medicine (IACLAM) convened a taskforce to examine the evidence for adverse welfare indicators in laboratory rats and mice undergoing CO euthanasia using a SYRCLE-registered systematic review protocol. Of 3,772 papers identified through a database search (PubMed, Web of Science, CAB Direct, Agricola, and grey literature) from 1900 to 2017, 37 studies were identified for detailed review (some including more than one species or age group), including 15 in adult mice, 21 in adult rats, and 5 in neonates of both species. Experiments or reports were excluded if they only assessed parameters other than those directly affecting animal welfare during CO induction and/or euthanasia. Results: Study design and outcome measures were highly variable and there was an unclear to high risk of bias in many of the published studies. Changes in the outcome measures evaluated were inconsistent or poorly differentiated. It is likely that repeated exposures to carbon dioxide inhalation are aversive to adult rats and mice, based on avoidance behavior studies; however, this effect is largely indistinguishable from aversion induced by repeated exposures to other inhalant anesthetic gasses. Conclusion: There is insufficient evidence to permit an unbiased assessment of the effect of CO inhalation during euthanasia on welfare indicators in laboratory mice and rats. Additional well-designed, unbiased, and adequately powered studies are needed to accurately assess the welfare of laboratory mice and rats undergoing euthanasia via CO gas