Global wealth disparities drive adherence to COVID-safe pathways in head and neck cancer surgery

Peer reviewe

Intellectual Property and the Governance of Plant Genetic Resources in Mexico: Trends and Implications for Research and Innovation

This chapter explores how the regulation of plant genetic resources intersects with legal regimes granting intellectual property rights in Mexico. Our analysis is directed towards addressing the argument that regimes governing access to plant genetic resources and the sharing of benefits derived from their commercial exploitation could discourage research and innovation in fields that rely on such resources as inputs. To engage with this critique, we examine the relationship between plant genetic resources and intellectual property, because trends in intellectual property protection may elucidate research and innovation dynamics. Our findings surrounding applications for patents and plant breeders’ rights in Mexico indicate that intellectual property activity related to plant genetic resources can intensify even as new frameworks for the governance of these resources are designed and popularized. However, it is important to note that it is still unknown whether the implementation of a national regime based on the Nagoya Protocol in Mexico might impact the activities of users and providers of genetic resources, including in relation to intellectual property protection

Qualitative modeling, analysis, and control of synthetic regulatory circuits

International audienceQualitative modeling approaches are promising and still underexploited tools for the analysis and design of synthetic circuits. They can make predictions of circuit behavior in the absence of precise, quantitative information. Moreover, they provide direct insight into the relation between the feedback structure and the dynamical properties of a network. We review qualitative modeling approaches by focusing on two specific formalisms, Boolean networks and piecewise-linear differential equations, and illustrate their application by means of three well-known synthetic circuits. We describe various methods for the analysis of state transition graphs, discrete representations of the network dynamics that are generated in both modeling frameworks. We also briefly present the problem of controlling synthetic circuits, an emerging topic that could profit from the capacity of qualitative modeling approaches to rapidly scan a space of design alternatives

The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study

AimThe SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery.MethodsThis was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin.ResultsOverall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P ConclusionOne in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease