13,751 research outputs found
Relationships between soil moisture-holding properties and soil texture, organic matter content, and bulk density
Specimens from the surface horizon and the subsoil of 62 soil horizons in Hedmark and Oppland were investigated to study how the mechanical composition of the soil, the organic matter content and the bulk density affect their porosity and air capacity and their total and available water content. Most of the specimens belonged to the loam group, and a smaller number was from sandy and silty types of soil. Equations were established to make it possible to calculate the water retention curves and the amount of available water from the above mentioned parameters. As a rule, errors derived from the equations are no greater than those which are found in similar research in other countries
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Suspension Design, Modeling, and Testing of a Thermo-Acoustic-Driven Linear Alternator
The Score-Stove™ generates electricity from a wood-burning cooking stove using a thermo-acoustic engine (TAE) that converts heat to sound through a linear alternator (LA). This paper introduces a prototype hemitoroidal suspension that was refined into a segmented trapezoidal shape that gave a higher cyclic life for the LA and includes a critical evaluation that compares a theoretical analysis with experimental results. The results show an improvement from the 40% efficiency of a standard loudspeaker used in reverse as an LA to 70–80% efficiency with the new suspension and a double Halbach array magnetic topology
A note on leapfrogging vortex rings
In this paper we provide examples, by numerical simulation using the Navier-Stokes equations for axisymmetric laminar flow, of the 'leapfrogging' motion of two, initially identical, vortex rings which share a common axis of symmetry. We show that the number of clear passes that each ring makes through the other increases with Reynolds number, and that as long as the configuration remains stable the two rings ultimately merge to form a single vortex ring
Selection Of A Novel Aptamer Against Vitronectin Using Capillary Electrophoresis And Next Generation Sequencing
Breast cancer (BC) results in ≃40,000 deaths each year in the United States and even among survivors treatment of the disease may have devastating consequences, including increased risk for heart disease and cognitive impairment resulting from the toxic effects of chemotherapy. Aptamer-mediated drug delivery can contribute to improved treatment outcomes through the selective delivery of chemotherapy to BC cells, provided suitable cancer-specific antigens can be identified. We report here the use of capillary electrophoresis in conjunction with next generation sequencing to develop the first vitronectin (VN) binding aptamer (VBA-01; Kd 405 nmol/l, the first aptamer to vitronectin (VN; Kd = 405 nmol/l), a protein that plays an important role in wound healing and that is present at elevated levels in BC tissue and in the blood of BC patients relative to the corresponding nonmalignant tissues. We used VBA-01 to develop DVBA-01, a dimeric aptamer complex, and conjugated doxorubicin (Dox) to DVBA-01 (7:1 ratio) using pH-sensitive, covalent linkages. Dox conjugation enhanced the thermal stability of the complex (60.2 versus 46.5°C) and did not decrease affinity for the VN target. The resulting DVBA-01-Dox complex displayed increased cytotoxicity to MDA-MB-231 BC cells that were cultured on plasticware coated with VN (1.8 × 10⁻⁶mol/l) relative to uncoated plates (2.4 × 10⁻⁶ mol/l), or plates coated with the related protein fibronectin (2.1 × 10⁻⁶ mol/l). The VBA-01 aptamer was evaluated for binding to human BC tissue using immunohistochemistry and displayed tissue specific binding and apparent association with BC cells. In contrast, a monoclonal antibody that preferentially binds to multimeric VN primarily stained extracellular matrix and vessel walls of BC tissue. Our results indicate a strong potential for using VN-targeting aptamers to improve drug delivery to treat BC
Electrodeposition in microgravity: Ground-based experiments
Electrodeposition was studied at one-hundreth g and compared with bench studies at 1 g. The low gravity was achieved during KC-135 aircraft parobolic flights. Flow in a simple cobalt cell (1 M CoSO4) operating under typical commercial conditions (10 to 20 mA/sq cm and 1 V) was monitored with a Schlieren optical system. Natural convection was absent at one-hundreth g. Quantitative comparisons on a cobalt cell with shielded electrodes using interferometry were carried out. Fringe shift differences indicate greater semi-infinite linear diffusion at 1 g than at one-hundreth g for cobalt. Since a shielded electrode operates under diffusion controlled conditions, no differences between 1 g and one-hundreth g would be expected. Similar comparisons on a shielded electrode copper cell were inconclusive. Bench codeposition experiments using polystyrene neutral buoyancy particles coupled with a shielded electrode cobalt cell were begun. Tracking of 12 micron particles showed no measurable difference between thermal/Brownian motion when the cell was operational or nonoperational. Initial experiments on codeposition quality showed a strong dependence upon cathode surface preparation in a shielded electrode configuration
Multilayered printed circuit boards inspected by X-ray laminography
Technique produces high resolution cross-sectional radiographs with close interplane spacing for inspecting multilayer boards to be used in providing circuitry routing and module structural support
Learning to perceive: informing pedagogic practice through the empirical study of drawing
This paper is the result of collaboration between psychologists with an interest in the cognitive processes underpinning drawing activity (Chamberlain, McManus and Brunswick), a dyslexia support tutor (Rankin) and an art school lecturer in drawing (Riley). It reports on a small-scale, ‘pilot’ workshop, designed to test the pedagogical strategies specifically designed for dyslexic students, with a cohort of volunteers from across the Royal College of Art, London
Talking the line: inclusive strategies for the teaching of drawing
The article reports on a series of drawing workshops held at the Royal College of Art (RCA), London, which tested an original pedagogical strategy designed to help dyslexic and/or dyspraxic art and design students who had reported difficulties with their abilities to make accurate representational drawings. A group of non-dyslexic/dyspraxic RCA students volunteered as control group, and both cohorts completed three days of workshops in the Drawing Studio of the RCA. Results of recorded interviews eliciting student observations as they drew, and a questionnaire in the form of a Likert scale, administered before and after the workshop, indicate positive shifts in both cohorts’ attitudes towards specific aspects of the stages involved in the production of accurate representational drawings of still-life set-ups, the human skeleton and the clothed life-model. Assessment of the drawings produced indicates positive shifts in the two cohorts in geometric accuracy and other qualitative criteria embedded in the teaching strategy such as control of scale, proportion and illusions of depth. Both cohorts displayed similar positive attitude shifts and both sets of drawings indicated similar positive shifts in visual qualities. An interim conclusion posits that the pedagogical strategy appears to enhance the abilities of both dyslexic/dyspraxic students and non-dyslexic/dyspraxic students to make accurate representational drawings. This result correlates closely with the findings of an earlier, prototype workshop held at the RCA in July 2012. It is suggested that similar pedagogically inclusive strategies might produce positive results in the context of secondary schools as part of a more inclusive curriculum
Scratching the surface: practice, personality, approaches to learning and the acquisition of high level representational drawing ability
Accurate representational drawing is a complex skill which underpins performance in many branches of the visual arts. Research suggests that expertise typically is acquired as a result of deliberate practice and a flexible approach to learning strategies. The current study investigated how, in art students, differences in the acquisition of observational drawing skill could be characterised using domain-general expertise accounts. A cohort of undergraduate and postgraduate art students (n=682) completed questionnaires about self-perceived artistic abilities, personality and approaches to learning. A subset completed tasks of actual drawing ability (n=301), the Rey-Osterrieth Complex Figure (ROCF) test and a performance IQ test. Actual drawing ability related to time spent drawing and drawing techniques, with additional independent predictive effects of both the copying and delayed ROCF test. Effects of personality were mainly mediated via learning styles, with surface learners spending more time drawing, learning fewer techniques and acquiring a lower level of actual skill. Deep learners learned more drawing techniques, and strategic (achieving) learners acquired a higher level of drawing skill overall. The resulting model of drawing ability development has the potential to be generalised over a range of creative and non-creative domains
The detection of airborne transmission of tuberculosis from HIV-infected patients, using an in vivo air sampling model
Background. Nosocomial transmission of tuberculosis remains an important public health problem. We created an in vivo air sampling model to study airborne transmission of tuberculosis from patients coinfected with human immunodeficiency virus (HIV) and to evaluate environmental control measures.
Methods. An animal facility was built above a mechanically ventilated HIV‐tuberculosis ward in Lima, Peru. A mean of 92 guinea pigs were continuously exposed to all ward exhaust air for 16 months. Animals had tuberculin skin tests performed at monthly intervals, and those with positive reactions were removed for autopsy and culture for tuberculosis.
Results. Over 505 consecutive days, there were 118 ward admissions by 97 patients with pulmonary tuberculosis, with a median duration of hospitalization of 11 days. All patients were infected with HIV and constituted a heterogeneous group with both new and existing diagnoses of tuberculosis. There was a wide variation in monthly rates of guinea pigs developing positive tuberculin test results (0%–53%). Of 292 animals exposed to ward air, 159 developed positive tuberculin skin test results, of which 129 had laboratory confirmation of tuberculosis. The HIV‐positive patients with pulmonary tuberculosis produced a mean of 8.2 infectious quanta per hour, compared with 1.25 for HIV‐negative patients with tuberculosis in similar studies from the 1950s. The mean monthly patient infectiousness varied greatly, from production of 0–44 infectious quanta per hour, as did the theoretical risk for a health care worker to acquire tuberculosis by breathing ward air.
Conclusions. HIV‐positive patients with tuberculosis varied greatly in their infectiousness, and some were highly infectious. Use of environmental control strategies for nosocomial tuberculosis is therefore a priority, especially in areas with a high prevalence of both tuberculosis and HIV infection
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