Results of bronchoscopic excision in typical carcinoid tumors of the lung in Turkey

Aim Carcinoid tumors of the lung are the tumors originating from the neuroendocrine cells. Surgical excision remains the gold standard for the treatment. Treatment with interventional bronchoscopic excision has also been reported as an alternative option in typical carcinoid tumors of the lung. The aim of this study was to present results and outcomes in patients who were bronchoscopically treated and followed-up. Methods Data of 14 patients, who had undergone bronchoscopic excision due to typical carcinoid tumor of the lung between April 2008 and July 2015 were retrospectively evaluated. Bronchoscopic excision procedures were performed under general anesthesia, while control bronchoscopies were carried out with flexible bronchoscopy. Time between the first and last bronchoscopies was accepted as the follow-up duration. Results A total of 14 patients was evaluated with eight (57.1%) males. Mean age was 43.57±14.07 (23-68) years. The most common symptoms were shortness of breath and coughing. Mean of 5.69±3.35 (2-12) bronchoscopy procedures were performed in the patients during the diagnosis, treatment and follow-up. Mean follow-up duration was 32.0±19.22 months. At the long-term follow-up, two patients developed 50% stenosis and one patient developed granulation tissue in the endobronchial treatment site. None of the patients developed recurrence during the mean 32-month follow-up. Conclusion Endobronchial treatment is a safe and successful treatment method in well selected typical carcinoid tumor cases that are centrally located, having no radiological suspicion of local or distant metastasis, distally visible but not located on the bronchi with a wide base on bronchoscopy

Strongly correlated models of high-temperature superconductivity

Ankara : Department of Physics and the Institute of Engineering and Science of Bilkent Univ., 1999.Thesis (Ph.D.) -- Bilkent University, 1999.Includes bibliographical references leaves 70-77.Son zamanlarda nanometrc büyüklüğündeki örneklerle ya|)dan tek ek'ktron ta.^ınma deneyleri, üstün iletkenlerin büyüklüklerinin alt sının ile ilgili soruyu yeniden gündeme getirmiştir, iler ne kadar, belirsiz tanecik sayısına dayalı standart BCS teorisi büyük örnekler için iyi sonuçlar vermekteyse de, nanometrc^ büyüklüğündeki örnekler için bu teorinin bazı temel noktalan tc^krar gözdi'iı geçirilmelidir. Bunun iıcin, sabit sayıda parçacık için bir eşleşme IIamiItoni;uı'ı, l'ernıi seviyesi etrafındaki dejenerasyon da göz önüne alınarak incelenmiştir. Dejenera.syona bağlı olarak, eşleşme etkisinin değişimi tartışılmıştır. İkinci bölümde, atomların elektron yörüngelerindeki daralmanın, eıı yakın komşular arasındaki atlama genliğine olan etkisini göz önüne alan bir ınodc'l llamiltonian üzerinde çalışılmıştır. Bu çalışma, zayıf etkileşim limitinde' analitik olarak, orta ve güçlü etkileşim limitlerinde ise sonlu bir atom geoiiK'trisinde sayısal hesaplama ile yapılmıştır. Atom sitelerindeki deşik yerleşiminin yörünge'sel daralmaya etkileri V ve W (to|)lam ve çarpım daralma terimleri) ('tkih'şim parametreleri ile verilmektedir. Çift parçacık Creen fonksiyonundaki belirsizlik noktası, kritik sıcaklık Tc’yj ve Tc üzerinde düzen parametresinin rahatlama hızı r (7 ’) ’yi belirlemektedir. Standart BCS üstımiletkenleriiıdeiı Farklı olarak, r sıfırdan farklı imajiner bir kısma sahiptir. Bu, nstiiailetkenin 7'^. lizeriıuh'ki direııciııin dalgalanmaları üzerine etki ediyor olabilir, 'lemel dnrmn ('iK'ijisi, parçacık sayısı ve manyetik akıya göre hesaplanmı.'jtır. Bir eı^leşnıe |)aramctresi olan A ,,’nin, Cooper kararsızlığı ile aynı bölgede ortaya çıktığı gösteriImiı^tiı·. llııbbard modeli {U > 0) ile yapılan hesaplar herhangi bir dolnInk değerinde hiçbir üstün iletkanlik özelliği göstermemiştir.Boyacı, HüseyinPh.D

Supercurrents and persistent currents in strongly correlated electron systems

Ankara : Department of Physics and Institute of Engineering and Science, Bilkent Univ., 1995.Thesis (Master's) -- Bilkent University, 1995.Includes bibliographical references leaves 63-68The lull understanding· ol’the solution Гог the 1-tl Hubbard model is of interest in its own right, and may provide clues to the understanding of higher dimensioned systiMiis. We have found tin? exact solution of tlie model for tw<j eh'ctrons, with a magnetic flux ар[)Н(ч1, and showed some new results. We have also made calculations for more than two electrons on a looj) with a magnetic flux through it, using the Bethe-ansatz equations. Within the assumption that oxygen orbitals may play a fundarnentid role in the superconductive properties of Си —О high IT matc.'iials, exact calculaticnis ol the ground-stat<' eu<‘igy for two electrons in the contraction mechanism have been performed, do test the beginning assumption, some numerical calculations have been i)resent(;d.Boyacı, HüseyinM.S

Statistical modeling of propagation channels for Terahertz band

Digital revolution and recent advances in telecommunications technology enable to design communication systems which operate within the regions close to the theoretical capacity limits. Ever-increasing demand for wireless communications and emerging numerous high-capacity services and applications mandate providers to employ more bandwidth-oriented solutions to meet the requirements. Trend and predictions point out that marketplace targets data rates around 10Gbps or even more within the upcoming decade. It is clear that such rates could only be achieved by employing more bandwidth with the state-of-The-Art technology. Considering the fact that bands in the range of 275GHz-3000GHz, which are known as Terahertz (THz) bands, are not allocated yet for specific active services around the globe, there is an enormous potential to achieve the desired data rates. Although THz bands look promising to achieve data rates on the order of several tens of Gbps, realization of fully operational THz communications systems obliges to carry out a multidisciplinary effort including statistical propagation and channel characterizations, adaptive transceiver designs, reconfigurable platforms, advanced signal processing algorithms and techniques along with upper layer protocols equipped with various security and privacy levels. Therefore, in this study, several important statistical parameters for line-of-sight (LOS) channels are measured. High resolution frequency domain measurements are carried out at single-sweep within a span of 60GHz. Impact of antenna misalignment under LOS conditions is also investigated. By validating exponential decay of the received power in both time and frequency domain, path loss exponent is examined for different frequencies along with the frequency-dependent path loss phenomenon. Furthermore, impact of humidity is also tested under LOS scenario. Measurement results are presented along with relevant discussions and future directions are provided as well

Simultaneous chronic invasive fungal infection and tracheal fungus ball mimicking cancer in an immunocompetent patient

WOS: 000378552900001PubMed ID: 27418930Fungal infections of the lung are uncommon and mainly affect people with immune deficiency. There are crucial problems in the diagnosis and treatment of this condition. Invasive pulmonary aspergillosis and candidiasis are the most common opportunistic fungal infections. Aspergillus species (spp.) are saprophytes molds that exist in nature as spores and rarely cause disease in immunocompetent individuals. In patients with immune deficiency or chronic lung disease, such as cavitary lung disease or bronchiectasis, Aspergillus may cause a variety of aspergillosis infections. Here we present a case of a 57-year-old patient without immunodeficiency or chronic lung disease who was diagnosed with endotracheal fungus ball and chronic fungal infection, possibly due to Aspergillus. Bronchoscopic examination showed a paralyzed right vocal cord and vegetating mass that was yellow in color, at the posterior wall of tracheal lumen. After 3 months, both the parenchymal and tracheal lesions were completely resolved

Recessive Lamc3 Mutations Cause Malformations of Occipital Cortical Development

The biological basis for regional and inter-species differences in cerebral cortical morphology is poorly understood. We focused on consanguineous Turkish families with a single affected member with complex bilateral occipital cortical gyration abnormalities. By using whole-exome sequencing, we initially identified a homozygous 2-bp deletion in LAMC3, the laminin. 3 gene, leading to an immediate premature termination codon. In two other affected individuals with nearly identical phenotypes, we identified a homozygous nonsense mutation and a compound heterozygous mutation. In human but not mouse fetal brain, LAMC3 is enriched in postmitotic cortical plate neurons, localizing primarily to the somatodendritic compartment. LAMC3 expression peaks between late gestation and late infancy, paralleling the expression of molecules that are important in dendritogenesis and synapse formation. The discovery of the molecular basis of this unusual occipital malformation furthers our understanding of the complex biology underlying the formation of cortical gyrations.Wo

The Impact of CoronaVac Vaccination on 28-day Mortality Rate of Critically Ill Patients with COVID-19 in Türkiye

Background:Vaccines against coronavirus disease-19 (COVID-19) have been effective in preventing symptomatic diseases, hospitalizations, and intensive care unit (ICU) admissions. However, data regarding the effectiveness of COVID-19 vaccines in reducing mortality among critically ill patients with COVID-19 remains unclear.Aims:To determine the vaccination status and investigate the impact of the COVID-19 vaccine on the 28-day mortality in critically ill patients with COVID-19.Study Design:Multicenter prospective observational clinical study.Methods:This study was conducted in 60 hospitals with ICUs managing critically ill patients with COVID-19. Patients aged ≥ 18 years with confirmed COVID-19 who were admitted to the ICU were included. The present study had two phases. The first phase was designed as a one-day point prevalence study, and demographic and clinical findings were evaluated. In the second phase, the 28-day mortality was evaluated.Results:As of August 11, 2021, 921 patients were enrolled in the study. The mean age of the patients was 65.42 ± 16.74 years, and 48.6% (n = 448) were female. Among the critically ill patients with COVID-19, 52.6% (n = 484) were unvaccinated, 7.7% (n = 71) were incompletely vaccinated, and 39.8% (n = 366) were fully vaccinated. A subgroup analysis of 817 patients who were unvaccinated (n = 484) or who had received two doses of the CoronaVac vaccine (n = 333) was performed. The 28-day mortality rate was 56.8% (n = 275) and 57.4% (n = 191) in the unvaccinated and two-dose CoronaVac groups, respectively. The 28-day mortality was associated with age, hypertension, the number of comorbidities, type of respiratory support, and APACHE II and sequential organ failure assessment scores (p < 0.05). The odds ratio for the 28-day mortality among those who had received two doses of CoronaVac was 0.591 (95% confidence interval: 0.413-0.848) (p = 0.004).Conclusion:Vaccination with at least two doses of CoronaVac within six months significantly decreased mortality in vaccinated patients than in unvaccinated patients