A centrifugally controlled circuit in the avian retina and its possible role in visual attention switching.

The isthmo-optic nucleus (ION) is the main source of efferents to the retina in birds. Isthmo-optic neurons project in topographical order on amacrine cells in the ventral parts of the retina, and a subclass of these known as proprioretinal neurons project onto the dorsal retina. We propose that, through the intermediary of the amacrine target cells, activity in the isthmo-optic pathway excites ganglion cells locally in the ventral retina but inhibits those in dorsal regions. This circuit would thereby mediate centrifugally controlled switches in attention between the dorsal retina, involved in feeding, and the more ventral parts, involved in scanning for predators. This hypothesis accounts for a wide range of disparate data from behavior, comparative anatomy, endocrinology, hodology, and neurophysiology

Contactless Gait Assessment in Home-like Environments

Gait analysis is an important part of assessments for a variety of health conditions, specifically neurodegenerative diseases. Currently, most methods for gait assessment are based on manual scoring of certain tasks or restrictive technologies. We present an unobtrusive sensor system based on light detection and ranging sensor technology for use in home-like environments. In our evaluation, we compared six different gait parameters, based on recordings from 25 different people performing eight different walks each, resulting in 200 unique measurements. We compared the proposed sensor system against two state-of-the art technologies, a pressure mat and a set of inertial measurement unit sensors. In addition to test usability and long-term measurement, multi-hour recordings were conducted. Our evaluation showed very high correlation (r>0.95) with the gold standards across all assessed gait parameters except for cycle time (r=0.91). Similarly, the coefficient of determination was high (R2>0.9) for all gait parameters except cycle time. The highest correlation was achieved for stride length and velocity (r≥0.98,R2≥0.95). Furthermore, the multi-hour recordings did not show the systematic drift of measurements over time. Overall, the unobtrusive gait measurement system allows for contactless, highly accurate long- and short-term assessments of gait in home-like environments

Phonon heat capacity and self-heating normal domains in NbTiN nanostrips

Self-heating normal domains in thin superconducting NbTiN nanostrips were characterized via steady-state hysteretic current-voltage characteristics measured at different substrate temperatures. The temperature dependence and the magnitude of the current, which sustains a domain in equilibrium at different voltages, can only be explained with a phonon heat capacity noticeably less than expected for 3-d Debye phonons. This reduced heat capacity coincides with the value obtained earlier from magnetoconductance and photoresponse studies of the same films. The rate of heat flow from electrons at a temperature Te to phonons in the substrate at a temperature TB is proportional to (T_e^p - T_B^p) with the exponent p~3, which differs from the exponents for heat flows mediated by the electron-phonon interaction or by escaping of 3-d Debye phonons via the film/substrate interface. We attribute both findings to the effect of the mean grain size on the phonon spectrum of thin granular NbTiN films. Our findings are significant for understanding the thermal transport in superconducting devices exploiting thin granular films

Waddlia chondrophila induces systemic infection, organ pathology, and elicits Th1-associated humoral immunity in a murine model of genital infection.

Waddlia chondrophila is a known bovine abortigenic Chlamydia-related bacterium that has been associated with adverse pregnancy outcomes in human. However, there is a lack of knowledge regarding how W. chondrophila infection spreads, its ability to elicit an immune response and induce pathology. A murine model of genital infection was developed to investigate the pathogenicity and immune response associated with a W. chondrophila infection. Genital inoculation of the bacterial agent resulted in a dose-dependent infection that spread to lumbar lymph nodes and successively to spleen and liver. Bacterial-induced pathology peaked on day 14, characterized by leukocyte infiltration (uterine horn, liver, and spleen), necrosis (liver) and extramedullary hematopoiesis (spleen). Immunohistochemistry demonstrated the presence of a large number of W. chondrophila in the spleen on day 14. Robust IgG titers were detected by day 14 and remained high until day 52. IgG isotypes consisted of high IgG2a, moderate IgG3 and no detectable IgG1, indicating a Th1-associated immune response. This study provides the first evidence that W. chondrophila genital infection is capable of inducing a systemic infection that spreads to major organs, induces uterus, spleen, and liver pathology and elicits a Th1-skewed humoral response. This new animal model will help our understanding of the mechanisms related to intracellular bacteria-induced miscarriages, the most frequent complication of pregnancy that affects one in four women

Magnetoconductance and photoresponse properties of disordered NbTiN films

We report on the experimental study of phonon properties and electron-phonon scattering in thin superconducting NbTiN films, which are intensively exploited in various applications. Studied NbTiN films with sub-10-nm thicknesses are disordered with respect to electron transport, the Ioffe-Regel parameter of kFle=2.5–3.0 (kF is the Fermi wave vector, and le is the electron mean free path), the inelastic electron-phonon interaction, and the product qTle≪1 (qT is the wave vector of a thermal phonon). By means of magnetoconductance and photoresponse techniques, we derive the inelastic electron-phonon scattering rate 1/τe-ph and determine sound velocities and phonon heat capacities. In the temperature range from 12 to 20 K, the scattering rate varies with temperature as 1/τe-ph∝T3.45±0.05; its value extrapolated to 10 K amounts to approximately 1/16 ps. Making a comparative analysis of our films and other films used in superconducting devices, such as polycrystalline granular NbN and amorphous WSi, we find a systematic reduction of the sound velocity in all these films by about 50% compared to the corresponding bulk crystalline materials. A corresponding increase in the phonon heat capacities in all these films is, however, less than the Debye model predicts. We attribute these findings to reduced film dimensionality and film morphology

Resonances Width in Crossed Electric and Magnetic Fields

We study the spectral properties of a charged particle confined to a two-dimensional plane and submitted to homogeneous magnetic and electric fields and an impurity potential. We use the method of complex translations to prove that the life-times of resonances induced by the presence of electric field are at least Gaussian long as the electric field tends to zero.Comment: 3 figure

Continuous and simultaneous multigas monitoring using a highly sensitive and selective photoacoustic sensor

A multi-gas photoacoustic sensor is reported. Simultaneous measurement of ammonia, carbon dioxide and water vapor is demonstrated at ppm level using semiconductor lasers. In-situ measurements to control the housing conditions of laboratory animals are presente

Morel_Moreau_Morella. The Metamorphoses of Adolfo Bioy Casares Invention in a (Re) Animating Universe

Adolfo Bioy Casares short novel The Invention of Morel (La invención de Morel, 1940) envisioned the wish of human beings to define themselves through technology, indeed to reanimate the human as a technological double in an environment that gradually becomes virtual. This article develops the relationships connecting The Invention of Morel with three animating forms: the phantasmagoria, the automaton, and the machine-environment, to stress the privileged association they make between invention and (re)animation. With this purpose, the paper examines key contributions to our understanding of simulation and automata in the field of animation theory, such as Alan Cholodenko s Speculations on the Animation Automaton , but also Joubert-Laurencin s La lettre volante. Quatre essais sur le cinema d animation, which directly addresses Bioy Casares story as a metaphor of animated cinema. Sigmund Freud s psychoanalytical approach to the field of aesthetics in The Uncanny , and subsequent theories like Masahiro Mori s The Uncanny Valley , are also taken into consideration.Lorenzo Hernández, MC. (2013). Morel_Moreau_Morella. The Metamorphoses of Adolfo Bioy Casares Invention in a (Re) Animating Universe. Animation: An interdisciplinary journal. 8(2):185-202. doi:10.1177/1746847713485535S18520282Buchan, S. (2011). The Quay Brothers. doi:10.5749/minnesota/9780816646586.001.0001Cholodenko, A. (2013). The Crypt, the Haunted House, of Cinema. Cultural Studies Review, 10(2), 99-113. doi:10.5130/csr.v10i2.3474Crafton, D. (1993). Before Mickey. doi:10.7208/chicago/9780226231020.001.000

Single-Mode Squeezed Light Generation and Tomography with an Integrated Optical Parametric Oscillator

Quantum optical technologies promise advances in sensing, computing, and communication. A key resource is squeezed light, where quantum noise is redistributed between optical quadratures. We introduce a monolithic, chip-scale platform that exploits the $\chi^{(2)}$ nonlinearity of a thin-film lithium niobate (TFLN) resonator device to efficiently generate squeezed states of light. Our system integrates all essential components -- except for the laser and two detectors -- on a single chip with an area of one square centimeter, significantly reducing the size, operational complexity, and power consumption associated with conventional setups. Our work addresses challenges that have limited previous integrated nonlinear photonic implementations that rely on either $\chi^{(3)}$ nonlinear resonators or on integrated waveguide $\chi^{(2)}$ parametric amplifiers. Using the balanced homodyne measurement subsystem that we implemented on the same chip, we measure a squeezing of 0.55 dB and an anti-squeezing of 1.55 dB. We use 20 mW of input power to generate the parametric oscillator pump field by employing second harmonic generation on the same chip. Our work represents a substantial step toward compact and efficient quantum optical systems posed to leverage the rapid advances in integrated nonlinear and quantum photonics.Comment: 21 pages; 4 figures in main body, 8 supplementary figure

Beyond aggression: Androgen-receptor blockade modulates social interaction in wild meerkats

In male vertebrates, androgens are inextricably linked to reproduction, social dominance, and aggression, often at the cost of paternal investment or prosociality. Testosterone is invoked to explain rank-related reproductive differences, but its role within a status class, particularly among subordinates, is underappreciated. Recent evidence, especially for monogamous and cooperatively breeding species, suggests broader androgenic mediation of adult social interaction. We explored the actions of androgens in subordinate, male members of a cooperatively breeding species, the meerkat (Suricata suricatta). Although male meerkats show no rank-related testosterone differences, subordinate helpers rarely reproduce. We blocked androgen receptors, in the field, by treating subordinate males with the antiandrogen, flutamide. We monitored androgen concentrations (via baseline serum and time-sequential fecal sampling) and recorded behavior within their groups (via focal observation). Relative to controls, flutamide-treated animals initiated less and received more high-intensity aggression (biting, threatening, feeding competition), engaged in more prosocial behavior (social sniffing, grooming, huddling), and less frequently initiated play or assumed a ‘dominant’ role during play, revealing significant androgenic effects across a broad range of social behavior. By contrast, guarding or vigilance and measures of olfactory and vocal communication in subordinate males appeared unaffected by flutamide treatment. Thus, androgens in male meerkat helpers are aligned with the traditional trade-off between promoting reproductive and aggressive behavior at a cost to affiliation. Our findings, based on rare endocrine manipulation in wild mammals, show a more pervasive role for androgens in adult social behavior than is often recognized, with possible relevance for understanding tradeoffs in cooperative systems