SN1987A and the Status of Oscillation Solutions to the Solar Neutrino Problem (including an appendix discussing the NC and day/night data from SNO)

We study neutrino oscillations and the level-crossing probability PLZ in power-law potential profiles A(r)\propto r^n. We give local and global adiabaticity conditions valid for all mixing angles theta and discuss different representations for PLZ. For the 1/r^3 profile typical of supernova envelopes we compare our analytical to numerical results and to earlier approximations used in the literature. We then perform a combined likelihood analysis of the observed SN1987A neutrino signal and of the latest solar neutrino data, including the recent SNO CC measurement. We find that, unless all relevant supernova parameters (released binding energy, \bar\nu_e and \bar\nu_{\mu,\tau} temperatures) are near their lowest values found in simulations, the status of large mixing type solutions deteriorates considerably compared to fits using only solar data. This is sufficient to rule out the vacuum-type solutions for most reasonable choices of astrophysics parameters. The LOW solution may still be acceptable, but becomes worse than the SMA-MSW solution which may, in some cases, be the best combined solution. On the other hand the LMA-MSW solution can easily survive as the best overall solution, although its size is generally reduced when compared to fits to the solar data only.Comment: 31 pages, 32 eps figures; 5 pages, 5 eps figures addendum in v2, discussing the recent SNO NC data and changes in SN paramete

Highly-parallelized simulation of a pixelated LArTPC on a GPU

The rapid development of general-purpose computing on graphics processing units (GPGPU) is allowing the implementation of highly-parallelized Monte Carlo simulation chains for particle physics experiments. This technique is particularly suitable for the simulation of a pixelated charge readout for time projection chambers, given the large number of channels that this technology employs. Here we present the first implementation of a full microphysical simulator of a liquid argon time projection chamber (LArTPC) equipped with light readout and pixelated charge readout, developed for the DUNE Near Detector. The software is implemented with an end-to-end set of GPU-optimized algorithms. The algorithms have been written in Python and translated into CUDA kernels using Numba, a just-in-time compiler for a subset of Python and NumPy instructions. The GPU implementation achieves a speed up of four orders of magnitude compared with the equivalent CPU version. The simulation of the current induced on 10^3 pixels takes around 1 ms on the GPU, compared with approximately 10 s on the CPU. The results of the simulation are compared against data from a pixel-readout LArTPC prototype

Controllability in Policy Games: Policy Neutrality and the Theory of Economic Policy Revisited

LQ-policy games, policy neutrality, policy effectiveness, controllability, Tinbergen system,

Synthesis and Biological Evaluation of N-((1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter-1

We previously disclosed the discovery of rationally designed N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1 (GlyT-1), represented by analogues 10 and 11. We describe herein further structure-activity relationship (SAR) exploration of this series via an optimization strategy that primarily focused on the sulfonamide and benzamide appendages of the scaffold. These efforts led to the identification of advanced leads possessing a desirable balance of excellent in vitro GlyT-1 potency and selectivity, favorable ADME and in vitro pharmacological profiles, and suitable pharmacokinetic (PK) and safety characteristics. Representative analogue (+)-67 exhibited robust in vivo activity in the cerebral spinal fluid (CSF) glycine biomarker model in both rodents and non-human primates. Furthermore, rodent microdialysis experiments also demonstrated that oral administration of (+)-67 significantly elevated extracellular glycine levels within the medial prefrontal cortex (mPFC)

Regulação da embriogênese semática in vitro com ênfase do papel de hormonios endógenos

Different aspects of the in vitro somatic embryogenesis regulation are reviewed in this paper.work. A description of g General aspects, such as terminology, uses, stages of development and factors associated with the somatic embryogenesis, are described. is carried out. Although a brief description ofn the effects of the addition of different plant growth regulators to the culture medium wasis given, the article is centereds itself on the effect that the endogenous hormone concentrations in the initial explants and in the tissue cultures derived from them could play oin the induction and expression of somatic embryogenesis. It is significant that few to emphasize the low amount of systematic studies have been conducted, in this subject, in which different species and hormone groups were compared in cultures with and without embryogenic capacity. Moreover, the lack of correlation between the results presented in different studies the distinct works indicates that the hormone content of the cultures is not the only factor involved.Neste trabalho se faz uma revisão de diversos aspectos da regulação da embriogêneses somático in vitro. Vários aspectos gerais a este fenômeno tem sido discutidos, tais como a definição de terminologia, descrição de eventuais aplicações, seus estados de desenvolvimento e outros fatores associados com sua indução e expressão. Embora se faça uma breve descrição do efeito da adição de diferentes reguladores de crescimento ao meio de cultivo, o artigo está centrado no efeito que as concentrações hormonais endogênas nos explantes iniciais e nos cultivos in vitro derivados deles podem ter na indução e expressão da embriogênese somática. Tem de se fazer ênfase na pouca quantidade de estudos sistemáticos realizados neste tema que comparem em várias espécies e diferentes grupos hormonais em cultivos com e sem competência embriogênica. Finalmente, indica-se que a falta de correlação entre os resultados destes poucos trabalhos parece indicar que os conteúdos hormonais endôgenos não são os únicos fatores envolvidos neste fenômeno.Grman Academic Exchange Service//DAAD/AlemaniaUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Agroalimentarias::Centro para Investigaciones en Granos y Semillas (CIGRAS