Training in social research skills from school: An experience at colegio Cundinamarca IED, Bogotá 2013 -2019

El artículo presenta una experiencia de formación en habilidades de investigación social, llevada a cabo con estudiantes de Ciclo V[1] en Ciudad Bolívar, localidad que, por sus condiciones, facilita la posibilidad de construir nuevos aprendizajes desde las realidades sociales experimentadas. El objetivo es implementar un proceso pedagógico de formación en investigación social con los estudiantes, a partir de una perspectiva interdisciplinar cuyo punto de partida son las ciencias sociales. Los resultados permiten destacar la importancia de la investigación social en la escuela, desde su posibilidad de generar formas de acercamiento a los problemas socio-estructurales de las comunidades.   [1] Nivel de formación en educación media, última fase para obtener el título de bachiller académico. Corresponde a los grados décimo y undécimo. La población estudiantil son jóvenes. Sus edades oscilan entre los 15 y 18 años y se encuentran en proceso de escoger opciones profesionales para el ingreso a la educación superior o el mundo productivo.The article presents a training experience in social research skills, carried out with Cycle V students in Ciudad Bolívar, a town that, due to its conditions, facilitates the possibility of building new learning from the experienced social realities. The objective is to implement a pedagogical process of training in social research with students, from an interdisciplinary perspective whose starting point is the social sciences. The results allow us to highlight the importance of social research at school, from its possibility of generating forms of approach to the socio-structural problems of the communities

BiP Heterozigosity Aggravates Pathological Deterioration in Experimental Amyotrophic Lateral Sclerosis

In the present study, we investigated the involvement of the chaperone protein BiP (also known as GRP78 or Hspa5), a master regulator of intracellular proteostasis, in two mouse models of neurodegenerative diseases: amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD). To this end, we used mice bearing partial genetic deletion of the BiP gene (BiP+/− mice), which, for the ALS model, were crossed with mutant SOD1 (mSOD1) transgenic mice to generate mSOD1/BiP+/− double mutant mice. Our data revealed a more intense neurological decline in the double mutants, reflected in a greater deterioration of the neurological score and rotarod performance, with also a reduced animal survival, compared to mSOD1 transgenic mice. Such worsening was associated with higher microglial (labelled with Iba-1 immunostaining) and, to a lesser extent, astroglial (labelled with GFAP immunostaining) immunoreactivities found in the double mutants, but not with a higher loss of spinal motor neurons (labelled with Nissl staining) in the spinal cord. The morphological analysis of Iba-1 and GFAP-positive cells revealed a higher presence of activated cells, characterized by elevated cell body size and shorter processes, in double mutants compared to mSOD1 mice with normal BiP expression. In the case of the PD model, BiP+/− mice were unilaterally lesioned with the parkinsonian neurotoxin 6-hydroxydopamine (6-OHDA). In this case, however, we did not detect a greater susceptibility to damage in mutant mice, as the motor defects caused by 6-OHDA in the pole test and the cylinder rearing test, as well as the losses in tyrosine hydroxylase-containing neurons and the elevated glial reactivity (labelled with CD68 and GFAP immunostaining) detected in the substantia nigra were of similar magnitude in BiP+/− mice compared with wildtype animals. Therefore, our findings support the view that a dysregulation of the protein BiP may contribute to ALS pathogenesis. As BiP has been recently related to cannabinoid type-1 (CB1) receptor function, our work also opens the door to future studies on a possible link between BiP and the neuroprotective effects of cannabinoids that have been widely reported in this neuropathological context. In support of this possibility, preliminary data indicate that CB1 receptor levels are significantly reduced in mSOD1 mice having partial deletion of BiP gene

Educación para el siglo XXI: Derechos humanos, ciudadanía y diversidad sexual

172 p. Libro ElectrónicoEste libro recoge el resultado de la sistematización del programa “Maestros y maestras que inspiran” de la línea de Derechos humanos, ciudadanía y diversidad sexual. Estos documentos contienen los relatos de los docentes participantes, como resultado del trabajo dentro y fuera de las aulas en diferentes colegios del Distrito Capital. Los docentes narran sus experiencias desde los diversos contextos, así como las diferentes metodologías utilizadas todas con el fin de forta-lecer la ciudadanía, no solo de sus estudiantes, sino de ellos mismos, de padres y madres de familia y la comunidad en general. Finalmente nos cuentan, cuáles fueron los principales logros y las recomendacio-nes para otros docentes que quieran seguir sus pasos

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Formación en habilidades de investigación social desde la escuela: Una experiencia en el Colegio Cundinamarca IED , Bogotá 2013 -2019

The article presents a training experience in social research skills, carried out with Cycle V students in Ciudad Bolívar, a town that, due to its conditions, facilitates the possibility of building new learning from the experienced social realities. The objective is to implement a pedagogical process of training in social research with students, from an interdisciplinary perspective whose starting point is the social sciences. The results allow us to highlight the importance of social research at school, from its possibility of generating forms of approach to the socio-structural problems of the communities.El artículo presenta una experiencia de formación en habilidades de investigación social, llevada a cabo con estudiantes de Ciclo V[1] en Ciudad Bolívar, localidad que, por sus condiciones, facilita la posibilidad de construir nuevos aprendizajes desde las realidades sociales experimentadas. El objetivo es implementar un proceso pedagógico de formación en investigación social con los estudiantes, a partir de una perspectiva interdisciplinar cuyo punto de partida son las ciencias sociales. Los resultados permiten destacar la importancia de la investigación social en la escuela, desde su posibilidad de generar formas de acercamiento a los problemas socio-estructurales de las comunidades.   [1] Nivel de formación en educación media, última fase para obtener el título de bachiller académico. Corresponde a los grados décimo y undécimo. La población estudiantil son jóvenes. Sus edades oscilan entre los 15 y 18 años y se encuentran en proceso de escoger opciones profesionales para el ingreso a la educación superior o el mundo productivo