A salivary metabolite signature that reflects gingival host-microbe interactions: instability predicts gingivitis susceptibility

Several proteins and peptides in saliva were shown to stimulate gingival wound repair, but the role of salivary metabolites in this process remains unexplored. In vitro gingival re-epithelialization kinetics were determined using unstimulated saliva samples from healthy individuals collected during an experimental gingivitis study. Elastic net regression with stability selection identified a specific metabolite signature in a training dataset that was associated with the observed re-epithelialization kinetics and enabled its prediction for all saliva samples obtained in the clinical study. This signature encompassed ten metabolites, including plasmalogens, diacylglycerol and amino acid derivatives, which reflect enhanced host-microbe interactions. This association is in agreement with the positive correlation of the metabolite signature with the individual’s gingival bleeding index. Remarkably, intra-individual signature-variation over time was associated with elevated risk for gingivitis development. Unravelling how these metabolites stimulate wound repair could provide novel avenues towards therapeutic approaches in patients with impaired wound healing capacity.</p

RDF to Conceptual Graphs Translations

International audienceIn this paper we will discuss two different translations between RDF (Resource Description Format) and Conceptual Graphs (CGs). These translations will allow tools like Cogui and Cogitant to be able to import and export RDF(S) documents. The first translation is sound and complete from a reasoning view point but is not visual nor a representation in the spirit of Conceptual Graphs (CGs). The second translation has the advantage of being natural and fully exploiting the CG features, but, on the other hand it does not apply to the whole RDF(S). We aim this paper as a preliminary report of ongoing work looking in detail at different pro and the cons of each approach

Associated production of H^{\pm} and W^{\mp} in high-energy e+e- collisions in the Minimal Supersymmetric Standard Model

We study the associated production of the charged Higgs boson and W^{\pm} gauge boson in high energy e+e- collisions in the Minimal Supersymmetric Standard Model (MSSM). This associated production, which first arises at the one loop level, offers the possibility of producing the charged Higgs boson at the e+e- collider with mass more than half the center-of-mass energy, when the charged Higgs pair production is kinematically forbidden. We present analytic and numerical results for the cross section for e+e- --> W+ H- in the full MSSM, taking into account the previously uncalculated contributions from supersymmetric (SUSY) particles. We find that the contributions of the SUSY particles enhance the cross section over most of SUSY parameter space, especially when the SUSY particles are light, ~200 GeV. With favorable SUSY parameters, at small tan beta, this process can yield more than ten W^{\pm}H^{\mp} events for m_{H^{\pm}} <~ 350 GeV in 500 fb-1 at a 500 GeV e+e- collider, or m_{H^{\pm}} <~ 600 GeV in 1000 fb-1 at a 1000 GeV collider. 80% left-handed polarization of the e- beam improves these reaches to m_{H^{\pm}} <~ 375 GeV and m_{H^{\pm}} <~ 670 GeV, respectively.Comment: v2: 21 pages, 9 figures, comments on Higgs search bounds and new references added, and minor changes; v3: 23 pages, 11 figures, review of literature moved from introduction to new Sec.5 and 2 plots added, references added, typos corrected; v4: bug fixed in nu nubar H0 cross section (Fig.11), version to appear in PR

Higher Twist Contributions To R-Hadron Phenomenology In The Light Gluino Scenario

The open light gluino window allows non-trivial higher twist gluino contributions to the proton wave function. Using a two-component model originally developed for charm hadroproduction, higher twist intrinsic gluino contributions to final state R-hadron formation are shown to enhance leading twist production in the forward $x_{F}$ region. We calculate R-hadron production at $p_{\rm{lab}}=800$ GeV in pp, pBe, and pCu interactions with light gluino masses of 1.2, 1.5, 3.5, and 5.0 GeV.Comment: 22 pages, 10 figures, revte

Time resolved particle dynamics in granular convection

We present an experimental study of the movement of individual particles in a layer of vertically shaken granular material. High-speed imaging allows us to investigate the motion of beads within one vibration period. This motion consists mainly of vertical jumps, and a global ordered drift. The analysis of the system movement as a whole reveals that the observed bifurcation in the flight time is not adequately described by the Inelastic Bouncing Ball Model. Near the bifurcation point, friction plays an important role, and the branches of the bifurcation do not diverge as the control parameter is increased. By fitting the grains trajectories near the wall it is possible to quantify the effective acceleration acting on them. A comparison of the mass centre flying time and the flying time determined for the grains near the wall exposes the underlying mechanism that causes the downward flow

Stability of the Scalar Potential and Symmetry Breaking in the Economical 3-3-1 Model

A detailed study of the criteria for stability of the scalar potential and the proper electroweak symmetry breaking pattern in the economical 3-3-1 model, is presented. For the analysis we use, and improve, a method previously developed to study the scalar potential in the two-Higgs-doublet extension of the standard model. A new theorem related to the stability of the potential is stated. As a consequence of this study, the consistency of the economical 3-3-1 model emerges.Comment: to be published in EPJ C, 13 page

Oportunidades de negocio en las cadenas de valor sostenibles para carne y leche

Oportunidades de negocio en las cadenas de valor sostenibles para carne y lech