Autonomy at work as a predictor of hardy personality and motivation in sport facilitators

This paper studies the predictive capacity of autonomy at work and the hardy personality of sports professionals on their motivation-effort. The sample is made up of 112 sports facilitators from Extremadura. The OccupationalResilience Questionnaire and the Multidimensional Organisational Climate Scale are used. The results show that the autonomy factor does not correlate equally strongly with the different components of the hardy personality. Thus, the level of strength in the relationship is as follows: control (β = .49) and challenge (β = .32) and commitment (β= .04). However, the latter factor, commitment, is the strongest predictor of motivation and effort (β = .69).The coefficient of determination (R2 = .54) indicates that autonomy and hardy personality predict 54% ofthe variance of engagement. And with respect to the autonomy-hardy personality-motivation and effortmodel, its level of prediction is 24% (R2 = .24). Finally, it should be noted that the autonomy variable offers itsstrongest predictive influence on motivation and effort, when it does so through the control and commitmentfactor of the resistant personality. It is concluded that autonomy does not equally influence hardy personalityand thus motivation and effort.Actividad Física y Deport

MedivozCaptura. Una aplicación en red segura de ayuda al profesional de ORL

MedivozCaptura es una herramienta informática desarrollada para asistir al análisis y detección de patologías vocales. Se basa en el almacenamiento en una base de datos relacional de señales de voz, electroglotogramas (EGG) y vídeoendoscopias, además de otros datos sobre los pacientes que los especialistas puedan considerar relevantes. El presente documento describe el funcionamiento de la aplicación de forma distribuida en red, con la base de datos centralizada, así como la problemática de seguridad y rendimiento que supone la distribución a través de la red o Internet y cómo se solventa en MedivozCaptur

Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease

Adipose tissue has recently been recognized as an important endocrine organ that plays a crucial role in energy metabolism and in the immune response in many metabolic tissues. With this regard, emerging evidence indicates that an important crosstalk exists between the adipose tissue and the brain. However, the contribution of adipose tissue to the development of age-related diseases, including Alzheimer's disease, remains poorly defined. New studies suggest that the adipose tissue modulates brain function through a range of endogenous biologically active factors known as adipokines, which can cross the blood–brain barrier to reach the target areas in the brain or to regulate the function of the blood–brain barrier. In this review, we discuss the effects of several adipokines on the physiology of the blood–brain barrier, their contribution to the development of Alzheimer's disease and their therapeutic potential.Funding for open access charge; Universidad de Málaga / CBU

Impact of HLA Mismatching on Early Subclinical Inflammation in Low-Immunological-Risk Kidney Transplant Recipients

The impact of human leukocyte antigen (HLA)-mismatching on the early appearance of subclinical inflammation (SCI) in low-immunological-risk kidney transplant (KT) recipients is undetermined. We aimed to assess whether HLA-mismatching (A-B-C-DR-DQ) is a risk factor for early SCI. As part of a clinical trial (Clinicaltrials.gov, number NCT02284464), a total of 105 low-immunological-risk KT patients underwent a protocol biopsy on the third month post-KT. As a result, 54 presented SCI, showing a greater number of total HLA-mismatches (p = 0.008) and worse allograft function compared with the no inflammation group (48.5 ± 13.6 vs. 60 ± 23.4 mL/min; p = 0.003). Multiple logistic regression showed that the only risk factor associated with SCI was the total HLA-mismatch score (OR 1.32, 95%CI 1.06-1.64, p = 0.013) or class II HLA mismatching (OR 1.51; 95%CI 1.04-2.19, p = 0.032) after adjusting for confounder variables (recipient age, delayed graft function, transfusion prior KT, and tacrolimus levels). The ROC curve illustrated that the HLA mismatching of six antigens was the optimal value in terms of sensitivity and specificity for predicting the SCI. Finally, a significantly higher proportion of SCI was seen in patients with >6 vs. ≤6 HLA-mismatches (62.3 vs. 37.7%; p = 0.008). HLA compatibility is an independent risk factor associated with early SCI. Thus, transplant physicians should perhaps be more aware of HLA mismatching to reduce these early harmful lesions

Clinical Relevance of Corticosteroid Withdrawal on Graft Histological Lesions in Low-Immunological-Risk Kidney Transplant Patients

The impact of corticosteroid withdrawal on medium-term graft histological changes in kidney transplant (KT) recipients under standard immunosuppression is uncertain. As part of an open-label, multicenter, prospective, phase IV, 24-month clinical trial (ClinicalTrials.gov, NCT02284464) in low-immunological-risk KT recipients, 105 patients were randomized, after a protocol-biopsy at 3 months, to corticosteroid continuation (CSC, n = 52) or corticosteroid withdrawal (CSW, n = 53). Both groups received tacrolimus and MMF and had another protocol-biopsy at 24 months. The acute rejection rate, including subclinical inflammation (SCI), was comparable between groups (21.2 vs. 24.5%). No patients developed dnDSA. Inflammatory and chronicity scores increased from 3 to 24 months in patients with, at baseline, no inflammation (NI) or SCI, regardless of treatment. CSW patients with SCI at 3 months had a significantly increased chronicity score at 24 months. HbA1c levels were lower in CSW patients (6.4 +/- 1.2 vs. 5.7 +/- 0.6%; p = 0.013) at 24 months, as was systolic blood pressure (134.2 +/- 14.9 vs. 125.7 +/- 15.3 mmHg; p = 0.016). Allograft function was comparable between groups and no patients died or lost their graft. An increase in chronicity scores at 2-years post-transplantation was observed in low-immunological-risk KT recipients with initial NI or SCI, but CSW may accelerate chronicity changes, especially in patients with early SCI. This strategy did, however, improve the cardiovascular profiles of patients

La confianza emocional vs. racional como objetivo de marketing en el contexto político

El presente artículo de reflexión desarrolla un análisis de los cambios producidos en la comunicación en el contexto político y la influencia que tienen los medios de comunicación. A partir de ahí, se centra en el valor de la confianza bajo un paradigma más racional y efímero. Por último se desarrollan estrategias prácticas para mejorar el engagement entre los seguidores.

The role of the professional of physical education as a member of primary social and health care services in Extremadura

En este artículo se justifica la necesidad del trabajo coordinado entre los profesionales de la actividad físico-deportiva y los de los servicios sanitarios, en Extremadura, con el objetivo de ofrecer el mejor servicio a la ciudadanía. Se incide en la importancia de concretar los tratamientos y de profundizar en el conocimiento de los recursos comunitarios para llevar a cabo un tratamiento más eficiente.The aim of this article is to account for the necessity to work coordinated between both professionals of physical education and health departments to offer the highest quality attention to the citizens in Extremadura. The importance of being specific about treatments and the knowledge of availableresources is emphasized to lead to more efficient results.peerReviewe

Flow cytometry immunophenotyping of fine-needle aspiration specimens: Utility in the diagnosis and classification of non-Hodgkin lymphomas

[Aims]: To establish the utility of flow cytometry (FCM) for screening and diagnosis of B cell non-Hodgkin lymphoma (B-NHL) from lymphoid tissue samples obtained by fine-needle aspiration (FNA). [Methods and results]: We compared prospectively FCM versus cytology/histology analysis of FNA samples for the diagnostic screening and further World Health Organization (WHO) subclassification of B-NHL. FCM and cytology showed a high degree of agreement (93%); however, diagnosis of reactive processes (RP), B-NHL and T-NHL by FCM showed higher sensitivity than cytology (92-100% versus 64-94%, respectively), without false positive NHL cases. The antibody combination used did not allow a positive diagnosis of Hodgkin lymphoma as distinct from a RP. A high concordance rate was found between FCM and histopathology (74%) in subtyping B-NHL. In this regard, mantle-cell lymphoma and chronic lymphocytic leukaemia/small lymphocytic lymphoma showed the highest degree of agreement (100% concordant rates). In turn, FCM showed higher sensitivity/specificity in classifying follicular lymphoma (FL) and large B cell lymphomas, while the opposite occurred for marginal-zone and lymphoplasmacytic lymphomas. [Conclusions]: FCM enhances the diagnostic ability of FNA cytology, playing a crucial role in a rapid and accurate differential diagnosis between RP, B-NHL and T-NHL. In addition, immunophenotyping of FNA samples contributes to a more precise subclassification of B-NHL when combined with histopathology and genetic/molecular data. © 2011 Blackwell Publishing Limited.This work has been supported partially by the RTICC RD06 ⁄ 0020 ⁄ 0035-FEDER, and FIS 08 ⁄ 90881 grants, from the Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, Madrid, Spain. JM Sayagués is supported by CP05 ⁄ 00321 grant, from the Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, Madrid, Spain.Peer Reviewe