Secure Inter-domain Routing and Forwarding via Verifiable Forwarding Commitments

The Internet inter-domain routing system is vulnerable. On the control plane, the de facto Border Gateway Protocol (BGP) does not have built-in mechanisms to authenticate routing announcements, so an adversary can announce virtually arbitrary paths to hijack network traffic; on the data plane, it is difficult to ensure that actual forwarding path complies with the control plane decisions. The community has proposed significant research to secure the routing system. Yet, existing secure BGP protocols (e.g., BGPsec) are not incrementally deployable, and existing path authorization protocols are not compatible with the current Internet routing infrastructure. In this paper, we propose FC-BGP, the first secure Internet inter-domain routing system that can simultaneously authenticate BGP announcements and validate data plane forwarding in an efficient and incrementally-deployable manner. FC-BGP is built upon a novel primitive, name Forwarding Commitment, to certify an AS's routing intent on its directly connected hops. We analyze the security benefits of FC-BGP in the Internet at different deployment rates. Further, we implement a prototype of FC-BGP and extensively evaluate it over a large-scale overlay network with 100 virtual machines deployed globally. The results demonstrate that FC-BGP saves roughly 55% of the overhead required to validate BGP announcements compared with BGPsec, and meanwhile FC-BGP introduces a small overhead for building a globally-consistent view on the desirable forwarding paths.Comment: 16 pages, 17 figure

Cofilin-1 is involved in regulation of actin reorganization during influenza A virus assembly and budding

Influenza A virus (IAV) assembly and budding on host cell surface plasma membrane requires actin cytoskeleton reorganization. The underlying molecular mechanism involving actin reorganization remains unclarified. In this study, we found that the natural antiviral compound petagalloyl glucose (PGG) inhibits F-actin reorganization in the host cell membrane during the late stage of IAV infection, which are associated with the suppression of total cofilin-1 level and its phosphorylation. Knock-down of cofilin-1 reduces viral yields. These findings provide the first evidence that cofilin-1 plays an important role in regulating actin reorganization during IAV assembly and budding

α‑Lipoic Acid Alleviated Fluoride-Induced Hepatocyte Injury via Inhibiting Ferroptosis

Fluoride is widely used in agricultural production and food packaging. Excessive fluoride in water and food is a serious threat to liver health. α-Lipoic acid, a natural free radical scavenger, has hepatoprotective properties. However, the protective effect of α-lipoic acid on fluorohepatotoxicity is uncertain. The aim of this study was to investigate the mechanism of ferroptosis in α-lipoic acid preventing fluoride-induced hepatotoxicity. Five-week-old ICR mice were treated with sodium fluoride (100 mg/L) and/or α-lipoic acid (200 mg/kg) for 9 weeks. The results showed that α-lipoic acid attenuated fluoride-induced damage to liver morphology and ultrastructure. Moreover, α-lipoic acid alleviated fluoride-induced iron accumulation, increased oxidative stress, and elevated lipid peroxidation in the liver. In addition, the mechanism study found that α-lipoic acid prevented fluoride-induced ferroptosis through the System Xc–/GPX4 axis, lipid peroxidation axis, and iron metabolism axis, but it was interestingly not regulated by mitochondrial free radical axis in the hepatocytes. Altogether, this study indicated that α-lipoic acid prevents fluoride-induced liver injury by inhibiting ferroptosis, which has potential implications for the prevention and treatment of fluoride-induced liver injury