Forced response of shrouded blades with a coupled static/dynamic approach

A coupled static-dynamic method is proposed and applied to bladed disks with shrouds, in order to calculate the nonlinear forced response in presence of friction damping in the frequency domain. The novel approach allows to improve the already existing methods, which require a preliminary static analysis

Expansion of magnetic clouds in the outer heliosphere

A large amount of magnetized plasma is frequently ejected from the Sun as coronal mass ejections (CMEs). Some of these ejections are detected in the solar wind as magnetic clouds (MCs) that have flux rope signatures. Magnetic clouds are structures that typically expand in the inner heliosphere. We derive the expansion properties of MCs in the outer heliosphere from one to five astronomical units to compare them with those in the inner heliosphere. We analyze MCs observed by the Ulysses spacecraft using insitu magnetic field and plasma measurements. The MC boundaries are defined in the MC frame after defining the MC axis with a minimum variance method applied only to the flux rope structure. As in the inner heliosphere, a large fraction of the velocity profile within MCs is close to a linear function of time. This is indicative of} a self-similar expansion and a MC size that locally follows a power-law of the solar distance with an exponent called zeta. We derive the value of zeta from the insitu velocity data. We analyze separately the non-perturbed MCs (cases showing a linear velocity profile almost for the full event), and perturbed MCs (cases showing a strongly distorted velocity profile). We find that non-perturbed MCs expand with a similar non-dimensional expansion rate (zeta=1.05+-0.34), i.e. slightly faster than at the solar distance and in the inner heliosphere (zeta=0.91+-0.23). The subset of perturbed MCs expands, as in the inner heliosphere, at a significantly lower rate and with a larger dispersion (zeta=0.28+-0.52) as expected from the temporal evolution found in numerical simulations. This local measure of the expansion also agrees with the distribution with distance of MC size,mean magnetic field, and plasma parameters. The MCs interacting with a strong field region, e.g. another MC, have the most variable expansion rate (ranging from compression to over-expansion)

Transcranial sonography in the diagnosis, follow-up and treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

We used a modified transcranial sonography technique to study the cortex of the temporal lobe, a brain region involved in the processing of functions that are often compromised in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) patients. We studied the meninges, the subarachnoidal space and the cortex. The spatial resolution and the ability to visualize structures of 200-300 µm size, led us to hypothesize that the linear structures parallel to the subarachnoidal space could be referred to the neuronal layers of the cortex. In real-time mode, we could observe pulsation of the meninges and the cortex synchronous with the heart beat and independent of blood flow. This pulsation was more evident at the level of the meninges, but it was also appreciable at the level of the layers of the cortex and it was not accompanied by any type of flow. In addition to these findings, we observed that the subject undergoing the procedure experienced a series of changes that might prove potentially useful in the treatment of ME/CFS. In particular, we observed a decrease of tachycardia accompanied by an increase in systolic blood pressure and by a significant increase in muscle strength measured by the degree of muscle fibre shortening at the level of the biceps brachii. These findings, together with the low cost and simplicity of the procedure, suggest that modified transcranial sonography has a significant potential in the study and treatment of ME/CFS

Could cadmium be responsible for some of the neurological signs and symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

According to the World Health Organization, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a neurological disease characterized by widespread inflammation and multi-systemic neuropathology. Aetiology and pathogenesis are unknown, and several agents have been proposed as causative agents or as factors perpetuating the syndrome. Exposure to heavy metals, with particular reference to mercury and gold in dental amalgams, has been considered among the triggers of ME/CFS. Here we hypothesize that cadmium, a widespread occupational and environmental heavy metal pollutant, might be associated with some of the neurological findings described in ME/CFS. In fact, ME/CFS patients show a decrease of the volume of the gray matter in turn associated with objective reduction of physical activity. Cadmium induces neuronal death in cortical neurons through a combined mechanism of apoptosis and necrosis and it could then be hypothesized that cadmium-induced neuronal cell death is responsible for some of the effects of cadmium on the central nervous system, i.e. a decrease in attention level and memory in exposed humans as well as to a diminished ability for training and learning in rats, that are symptoms typical of ME/CFS. This hypothesis can be tested by measuring cadmium exposure in a cohort of ME/CFS patients compared with matched healthy controls, and by measuring gray matter volume in un-exposed healthy controls, exposed non-ME/CFS subjects, un-exposed ME/CFS patients and exposed ME/CFS patients. In addition, we hypothesize that cadmium exposure could be associated with reduced cerebral blood flow in ME/CFS patients because of the disruptive effects of cadmium on angiogenesis. In fact, cadmium inhibits angiogenesis and low global cerebral flow is associated with abnormal brain neuroimaging results and brain dysfunction in the form of reduced cognitive testing scores in ME/CFS patients. This hypothesis can be tested by measuring cerebral cortex blood flow in un-exposed healthy controls, exposed non-ME/CFS subjects, un-exposed ME/CFS patients and exposed ME/CFS patients. If our hypothesis is demonstrated correct, the consequences could affect prevention, early diagnosis, and treatment of ME/CFS. Implications in early diagnosis could entail the evaluation of symptoms typical of ME/CFS in cadmium-exposed subjects as well as the search for signs of exposure to cadmium in subjects diagnosed with ME/CFS. Nutritional supplementation of magnesium and zinc could then be considered, since these elements have been proposed in the prophylaxis and therapy of cadmium exposure, and magnesium was demonstrated effective on ME/CFS patients' symptom profiles

Intrusion Detection in Industrial Networks via Data Streaming

Given the increasing threat surface of industrial networks due to distributed, Internet-of-Things (IoT) based system architectures, detecting intrusions in\ua0 Industrial IoT (IIoT) systems is all the more important, due to the safety implications of potential threats. The continuously generated data in such systems form both a challenge but also a possibility: data volumes/rates are high and require processing and communication capacity but they contain information useful for system operation and for detection of unwanted situations.In this chapter we explain that\ua0 stream processing (a.k.a. data streaming) is an emerging useful approach both for general applications and for intrusion detection in particular, especially since it can enable data analysis to be carried out in the continuum of edge-fog-cloud distributed architectures of industrial networks, thus reducing communication latency and gradually filtering and aggregating data volumes. We argue that usefulness stems also due to\ua0 facilitating provisioning of agile responses, i.e. due to potentially smaller latency for intrusion detection and hence also improved possibilities for intrusion mitigation. In the chapter we outline architectural features of IIoT networks, potential threats and examples of state-of-the art intrusion detection methodologies. Moreover, we give an overview of how leveraging distributed and parallel execution of streaming applications in industrial setups can influence the possibilities of protecting these systems. In these contexts, we give examples using electricity networks (a.k.a. Smart Grid systems).We conclude that future industrial networks, especially their Intrusion Detection Systems (IDSs), should take advantage of data streaming concept by decoupling semantics from the deployment

The Cerebellar Dopaminergic System

In the central nervous system (CNS), dopamine (DA) is involved in motor and cognitive functions. Although the cerebellum is not been considered an elective dopaminergic region, studies attributed to it a critical role in dopamine deficit-related neurological and psychiatric disorders [e.g., Parkinson's disease (PD) and schizophrenia (SCZ)]. Data on the cerebellar dopaminergic neuronal system are still lacking. Nevertheless, biochemical studies detected in the mammalians cerebellum high dopamine levels, while chemical neuroanatomy studies revealed the presence of midbrain dopaminergic afferents to the cerebellum as well as wide distribution of the dopaminergic receptor subtypes (DRD1-DRD5). The present review summarizes the data on the cerebellar dopaminergic system including its involvement in associative and projective circuits. Furthermore, this study also briefly discusses the role of the cerebellar dopaminergic system in some neurologic and psychiatric disorders and suggests its potential involvement as a target in pharmacologic and non-pharmacologic treatments

A novel role for a major component of the vitamin D axis: vitamin D binding protein-derived macrophage activating factor induces human breast cancer cell apoptosis through stimulation of macrophages.

The role of vitamin D in maintaining health appears greater than originally thought, and the concept of the vitamin D axis underlines the complexity of the biological events controlled by biologically active vitamin D (1,25(OH)(2)D3), its two binding proteins that are the vitamin D receptor (VDR) and the vitamin D-binding protein-derived macrophage activating factor (GcMAF). In this study we demonstrate that GcMAF stimulates macrophages, which in turn attack human breast cancer cells, induce their apoptosis and eventually phagocytize them. These results are consistent with the observation that macrophages infiltrated implanted tumors in mice after GcMAF injections. In addition, we hypothesize that the last 23 hydrophobic amino acids of VDR, located at the inner part of the plasma membrane, interact with the first 23 hydrophobic amino acids of the GcMAF located at the external part of the plasma membrane. This al1ows 1,25(OH)(2)D3 and oleic acid to become sandwiched between the two vitamin D-binding proteins, thus postulating a novel molecular mode of interaction between GcMAF and VDR. Taken together, these results support and reinforce the hypothesis that GcMAF has multiple biological activities that could be responsible for its anti-cancer effects, possibly through molecular interaction with the VDR that in turn is responsible for a multitude of non-genomic as well as genomic effects

Dynamical evolution of a magnetic cloud from the Sun to 5.4 AU

Magnetic Clouds (MCs) are a particular subset of Interplanetary Coronal Mass Ejections (ICMEs), forming large scale magnetic flux ropes. In this work we analyze the evolution of a particular MC (observed on March 1998) using {\it in situ} observations made by two spacecraft approximately aligned with the Sun, the first one at 1 AU from the Sun and the second one at 5.4 AU. We study the MC expansion, its consequent decrease of magnetic field intensity and mass density, and the possible evolution of the so-called global ideal-MHD nvariants. We describe the magnetic configuration of the MC at both spacecraft using different models and compute relevant global quantities (magnetic fluxes, helicity and energy) at both helio-distances. We also track back this structure to the Sun, in order to find out its solar source. We find that the flux rope is significantly distorted at 5.4 AU. However, we are able to analyze the data before the flux rope center is over-passed and compare it with observations at 1 AU. From the observed decay of magnetic field and mass density, we quantify how anisotropic is the expansion, and the consequent deformation of the flux rope in favor of a cross section with an aspect ratio at 5.4 AU of $\approx 1.6$ (larger in the direction perpendicular to the radial direction from the Sun). We quantify the ideal-MHD invariants and magnetic energy at both locations, and find that invariants are almost conserved, while the magnetic energy decays as expected with the expansion rate found. The use of MHD invariants to link structures at the Sun and the interplanetary medium is supported by the results of this multispacecraft study. We also conclude that the local dimensionless expansion rate, that is computed from the velocity profile observed by a single spacecraft, is very accurate for predicting the evolution of flux ropes in the solar wind.Comment: 16 two-column pages, 8 figures. Accepted for publication in A&