3,313 research outputs found
Techniques de Pointage à Distance : Cibles Numériques et Cibles Physique
National audienceAu sein d'un environnement ubiquitaire, l'ordinateur devient évanescent : nos objets quotidiens sont augmentés d'électronique, les environnements deviennent perceptifs déconfinant l'interaction homme-machine de l'ancien ordinateur "boîte grise" à des espaces pervasifs. Désormais, l'utilisateur évolue dans un monde physico-numérique ou espace interactif mixte. Au sein de cet espace interactif, un besoin est alors d'interagir à distance que ce soit pour manipuler des objets numériques sur un écran distant ou des objets physiques. Cet article est dédié aux techniques de pointage à distance pour désigner un objet numérique ou physique. Nous décrivons six techniques de pointage pour interagir dans un environnement ubiquitaire, la première pour pointer à distance sur des cibles numériques, les cinq autres pour pointer sur des objets physiques avec et sans un dispositif mobile
Hypersonic rugate filters based on porous silicon
Periodic solid state structures exhibit transmission stopbands for waves of certain frequencies. We demonstrate porous silicon based rugate filters with 40 dB rejection first-order stopbands for longitudinal acoustic waves at hypersonic frequencies and the predicted suppression of higher order bands
Equisetum species show uniform epicuticular wax structures but diverse composition patterns
In the Equisetopsida, different wax distribution and composition patterns in the plant organs indicate a close relationship between wax structure and chemistry and the assimilatory function of these organs. Diverging wax compound classes show the two subgenera of Equisetum to be well separated
Results of the BiPo-1 prototype for radiopurity measurements for the SuperNEMO double beta decay source foils
The development of BiPo detectors is dedicated to the measurement of
extremely high radiopurity in Tl and Bi for the SuperNEMO
double beta decay source foils. A modular prototype, called BiPo-1, with 0.8
of sensitive surface area, has been running in the Modane Underground
Laboratory since February, 2008. The goal of BiPo-1 is to measure the different
components of the background and in particular the surface radiopurity of the
plastic scintillators that make up the detector. The first phase of data
collection has been dedicated to the measurement of the radiopurity in
Tl. After more than one year of background measurement, a surface
activity of the scintillators of (Tl) 1.5
Bq/m is reported here. Given this level of background, a larger BiPo
detector having 12 m of active surface area, is able to qualify the
radiopurity of the SuperNEMO selenium double beta decay foils with the required
sensitivity of (Tl) 2 Bq/kg (90% C.L.) with a six
month measurement.Comment: 24 pages, submitted to N.I.M.
Spectral modeling of scintillator for the NEMO-3 and SuperNEMO detectors
We have constructed a GEANT4-based detailed software model of photon
transport in plastic scintillator blocks and have used it to study the NEMO-3
and SuperNEMO calorimeters employed in experiments designed to search for
neutrinoless double beta decay. We compare our simulations to measurements
using conversion electrons from a calibration source of and show
that the agreement is improved if wavelength-dependent properties of the
calorimeter are taken into account. In this article, we briefly describe our
modeling approach and results of our studies.Comment: 16 pages, 10 figure
Non-target screening with high-resolution mass spectrometry: critical review using a collaborative trial on water analysis
In this article, a dataset from a collaborative nontarget
screening trial organised by the NORMAN Association
is used to review the state-of-the-art and discuss future perspectives
of non-target screening using high-resolution mass
spectrometry in water analysis. A total of 18 institutes from
12 European countries analysed an extract of the same water
sample collected from the River Danube with either one or both
of liquid and gas chromatography coupled with mass spectrometry detection. This article focuses mainly on the
use of high resolution screening techniques with target, suspect,
and non-target workflows to identify substances in environmental
samples. Specific examples are given to emphasise major
challenges including isobaric and co-eluting substances, dependence
on target and suspect lists, formula assignment, the
use of retention information, and the confidence of identification.
Approaches and methods applicable to unit resolution data
are also discussed. Although most substances were identified
using high resolution data with target and suspect-screening
approaches, some participants proposed tentative non-target
identifications. This comprehensive dataset revealed that nontarget
analytical techniques are already substantially
harmonised between the participants, but the data processing
remains time-consuming. Although the objective of a Bfullyautomated
identification workflow^ remains elusive in the
short term, important steps in this direction have been taken,
exemplified by the growing popularity of suspect screening
approaches. Major recommendations to improve non-target
screening include better integration and connection of desired
features into software packages, the exchange of target and
suspect lists, and the contribution of more spectra from standard
substances into (openly accessible) databases.This work was supported in part by the SOLUTIONS project, which received
funding from the European Union’s Seventh Framework Programme for
research, technological development and demonstration under Grant
Agreement No. 603437
Probing New Physics Models of Neutrinoless Double Beta Decay with SuperNEMO
The possibility to probe new physics scenarios of light Majorana neutrino
exchange and right-handed currents at the planned next generation neutrinoless
double beta decay experiment SuperNEMO is discussed. Its ability to study
different isotopes and track the outgoing electrons provides the means to
discriminate different underlying mechanisms for the neutrinoless double beta
decay by measuring the decay half-life and the electron angular and energy
distributions.Comment: 17 pages, 14 figures, to be published in E.P.J.
Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study
Background: Adrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM (bio-ADM) show an inverse relationship with blood pressure and a direct relationship with vasopressor requirement. In the present prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock 1 (, AdrenOSS-1) study, we assessed relationships between circulating bio-ADM during the initial intensive care unit (ICU) stay and short-term outcome in order to eventually design a biomarker-guided randomized controlled trial. Methods: AdrenOSS-1 was a prospective observational multinational study. The primary outcome was 28-day mortality. Secondary outcomes included organ failure as defined by Sequential Organ Failure Assessment (SOFA) score, organ support with focus on vasopressor/inotropic use, and need for renal replacement therapy. AdrenOSS-1 included 583 patients admitted to the ICU with sepsis or septic shock. Results: Circulating bio-ADM levels were measured upon admission and at day 2. Median bio-ADM concentration upon admission was 80.5 pg/ml [IQR 41.5-148.1 pg/ml]. Initial SOFA score was 7 [IQR 5-10], and 28-day mortality was 22%. We found marked associations between bio-ADM upon admission and 28-day mortality (unadjusted standardized HR 2.3 [CI 1.9-2.9]; adjusted HR 1.6 [CI 1.1-2.5]) and between bio-ADM levels and SOFA score (p < 0.0001). Need of vasopressor/inotrope, renal replacement therapy, and positive fluid balance were more prevalent in patients with a bio-ADM > 70 pg/ml upon admission than in those with bio-ADM ≤ 70 pg/ml. In patients with bio-ADM > 70 pg/ml upon admission, decrease in bio-ADM below 70 pg/ml at day 2 was associated with recovery of organ function at day 7 and better 28-day outcome (9.5% mortality). By contrast, persistently elevated bio-ADM at day 2 was associated with prolonged organ dysfunction and high 28-day mortality (38.1% mortality, HR 4.9, 95% CI 2.5-9.8). Conclusions: AdrenOSS-1 shows that early levels and rapid changes in bio-ADM estimate short-term outcome in sepsis and septic shock. These data are the backbone of the design of the biomarker-guided AdrenOSS-2 trial. Trial registration: ClinicalTrials.gov, NCT02393781. Registered on March 19, 2015
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