PIERO PELLEGRINO, L'«animus communitatis» e l'«adprobatio legislatoris» nell'attuale dottrina canonistica della consuetudine antinomica, Dott. A. Giuffrè Editore, Milano, 1995, 1 vol. de VI + 341 pp. [RECENSIÓN]

We propose a method to generate nonclassical states of light in multimode microwave cavities. Our approach considers two-photon processes that take place in a system composed of N extended cavities and an ultrastrongly coupled light-matter system. Under specific resonance conditions, our method generates, in a deterministic manner, product states of uncorrelated photon pairs, Bell states, and W states in different modes on the extended cavities. Furthermore, the numerical simulations show that the generation scheme exhibits a collective effect which decreases the generation time in the same proportion as the number of extended cavity increases. Moreover, the entanglement encoded in the photonic states can be transferred towards ancillary two-level systems to generate genuine multipartite entanglement. Finally, we discuss the feasibility of our proposal in circuit quantum electrodynamics. This proposal could be of interest in the context of quantum random number generator, due to the quadratic scaling of the output state.The authors acknowledge support from CEDENNA, Financiamiento Basal para Centros Cientificos y Tecnologicos de Excelencia FB.0807, Direccion de Postgrado USACH, FONDECYT Grant No. 1150653 and No. 1140194, Spanish MINECO/FEDER FIS2015-69983-P, Basque Government IT986-16, and Ramon y Cajal Grant RYC-2012-11391. This material is also based upon work supported by the projects OpenSuperQ and QMiCS of the EU Flagship on Quantum Technologies, and by the U.S. Department of Energy, Office of Science, Office of Advanced Scientific Computing Research (ASCR) quantum algorithm teams program, under field work proposal number ERKJ333

Árboles notables: un aporte a la belleza escénica de la ciudad de Cali (Colombia)

Introducción: La belleza escénica es reconocida como un servicio del ecosistema cultural cuyo valor estético se percibe en un nivel de paisaje holístico. Objetivo: Este estudio tuvo como objetivo la medición de variables dasométricas de individuos seleccionados como árboles notables, correspondientes a las especies Albizia saman y Ceiba pentandra en dos escenarios. Materiales y métodos: se realizaron mediciones en dos áreas del área urbana de la ciudad de Cali (Colombia): ubicaciones de la ciudad y el campus Meléndez de la Universidad del Valle. Un análisis estadístico descriptivo con el software Infostat de las variables dasométricas fue realizado de las dos especies objeto de estudio. Resultados: Los individuos forestales estudiados corresponden a Árboles Notables declarados en el municipio de Santiago de Cali, representando el 35,47% y 32,09% de los declarados como tales Se presentaron diferencias para cada una de las especies (p<0,05), en función de los espacios establecidos, aunque sus dimensiones eran las esperadas dado el estado maduro y de desarrollo que fue uno de los criterios en la elección de los individuos forestales para su clasificación como Árboles Notables. Conclusión: Este estudio se podrá utilizar como base para emprender proyectos planificación y manejo del componente arbóreo en la ciudad que contribuyan a la gestión integral de la belleza escénica de Cali

Estrategia de informatización en las carreras de la Universidad de Granma (Original).

The research responds to the problem related to the insufficiencies in the efficient use of Information and Communication Technologies in the careers of the University of Granma, which limit the solution of problems. The practical contribution consists of a pedagogical strategy for the improvement of the informatization process in the careers of the University of Granma, based on the efficient use of Information and Communication Technologies, which is an instrument for the concretion in practice; In it, the stages and actions defined allow diagnosing, planning, executing and evaluating this process based on the technological conditions of the context where it is developed, the active and conscious participation of students in their training, the role of the academic year group, the execution of academic, research, work and extracurricular activities, the determination of impacts on training and the efficient application of evaluation methods.La investigación responde al problema relacionado con las insuficiencias en el uso eficiente de las Tecnologías de la Información y las Comunicaciones en las carreras de la Universidad de Granma, que limitan la solución de problemas. El aporte práctico consiste en una estrategia pedagógica para el perfeccionamiento del proceso de informatización en las carreras de la Universidad de Granma, a partir del uso eficiente de las Tecnologías de la Información y las Comunicaciones, la cual es un instrumento para la concreción en la práctica; en ella, las etapas y acciones definidas permiten diagnosticar, planificar, ejecutar y evaluar dicho proceso a partir de las condiciones tecnológicas del contexto donde se desarrolla, la participación activa y consciente de los estudiantes en su formación, el papel del colectivo de año académico, la ejecución de actividades académicas, investigativas, laborales y extracurriculares, la determinación de impactos en la formación y la aplicación eficiente de las formas de evaluación

La resolución de problemas de estimación aplicando modelos matemáticos de regresión lineal y tecnologías informáticas. (Original)

In this investigation is show, the problem solving of magnitudes estimate, in the Physical culture and sports with the information-technology use in the problem solution, the proposed is utilizes the case of study, in order to guide contents of the simple and multiple linear regression models are applied, it evidence as estimate the baseball player average to depart of one or more independent variable, also are analyzed the    model validation and the solution process interpretation.En esta investigación, se utilizó el estudio de casos, para describir cómo orientar contenidos sobre los modelos de regresión lineal simple y múltiple, aplicados a la resolución de problemas de estimación de magnitudes con el uso de las tecnologías informáticas en la especialidad de Cultura Física y Deporte, en la solución de los problemas propuestos, se muestra como estimar el promedio de bateo de un pelotero a partir de una o más variables independientes, también se analizaron los procesos de validación del modelo y la interpretación de la solución

High dose chemotherapy and autologous stem cell transplantation in patients with peripheral T-cell lymphoma not achieving complete response after induction chemotherapy. The GEL-TAMO experience

Background and objectives: patients with aggressive non-Hodgkin's lymphomas (NHL) who do not obtain a complete response (CR) after induction chemotherapy have a poor prognosis. However, provided they are sensitive to the first regimen of chemotherapy, 25-40% of them with a B-cell phenotype may achieve long-term survival when treated with high dose chemotherapy and autologous stem cell transplantation (HDC/ASCT). The aim of this study was to analyze the efficacy of this therapy in the corresponding patients with peripheral T-cell lymphoma (PTCL). Design and methods: we retrospectively evaluated the efficacy of ASCT in 35 patients with PTCL from the GEL-TAMO registry, who did not achieve a CR to standard induction chemotherapy regimens for aggressive NHL. Thirty-one patients underwent transplantation after achieving a partial response (PR) and 4 patients were non-responders. Results: following HDC/ASCT, 23 (66%) of the patients achieved a CR, 4 (11%) a PR and in 7 (20%) cases the transplant failed. One patient was not evaluated because of early toxic death. With a median follow-up of the survivors of 37.5 months, 18 patients (51%) are alive and 15 patients (43%) are free of disease. Transplant-related mortality rate at 100 days was 11% and at 5 years the probabilities of survival, freedom from progression and disease-free survival for complete responders were 37%, 36% and 55% respectively. Pre-transplant lactate-dehydrogenase level, age-adjusted International Prognostic Index (aa-IPI) and tumor score correlated with survival. Interpretation and conclusions: one third of the patients with PTCL who fail to achieve CR to the first chemotherapeutic regimen can be rescued with HDC/ASCT. Pre-transplant values of IPI and tumor score risk systems for aggressive lymphomas were useful to predict subsequent survival

Real‐world evidence of tisagenlecleucel for the treatment of relapsed or refractory large B‐cell lymphoma

Tisagenlecleucel (tisa-cel) is a second-generation autologous CD19-targeted chimeric antigen receptor (CAR) T-cell therapy approved for relapsed/refractory (R/R) large B-cell lymphoma (LBCL). The approval was based on the results of phase II JULIET trial, with a best overall response rate (ORR) and complete response (CR) rate in infused patients of 52% and 40%, respectively. We report outcomes with tisa-cel in the standard-of-care (SOC) setting for R/R LBCL. Data from all patients with R/R LBCL who underwent leukapheresis from December 2018 until June 2020 with the intent to receive SOC tisa-cel were retrospectively collected at 10 Spanish institutions. Toxicities were graded according to ASTCT criteria and responses were assessed as per Lugano 2014 classification. Of 91 patients who underwent leukapheresis, 75 (82%) received tisa-cel therapy. Grade 3 or higher cytokine release syndrome and neurotoxicity occurred in 5% and 1%, respectively; non-relapse mortality was 4%. Among the infused patients, best ORR and CR were 60% and 32%, respectively, with a median duration of response of 8.9 months. With a median follow-up of 14.1 months from CAR T-cell infusion, median progression-free survival and overall survival were 3 months and 10.7 months, respectively. At 12 months, patients in CR at first disease evaluation had a PFS of 87% and OS of 93%. Patients with an elevated lactate dehydrogenase showed a shorter PFS and OS on multivariate analysis. Treatment with tisa-cel for patients with relapsed/refractory LBCL in a European SOC setting showed a manageable safety profile and durable complete responses

Allogeneic Stem Cell Transplantation in Mature T Cell and Natural Killer/T Neoplasias: A Registry Study from Spanish GETH/GELTAMO Centers

Despite advances in understanding the biology of mature T and natural killer (NK)/T cell neoplasia, current therapies, even the most innovative ones, are still far from ensuring its cure. The only treatment to date that has been shown to control aggressive T cell neoplasms in the long term is allogeneic stem cell transplantation (alloSCT). We aim to report the results of alloSCT for advanced mature T and NK/T neoplasias performed in centers from our national GELTAMO/GETH (Grupo Español de Linfoma y Trasplante de Médula Ósea/Grupo Español de Trasplante Hematopoyético y Terapia Celular) over the past 25 years. As a secondary objective, we analyzed the results of alloSCT from haploidentical donors. We performed a retrospective analysis of all patients who received an alloSCT in Spanish centers (n = 201) from September 1995 to August 2018. The 2-year overall survival (OS) and disease-free survival (DFS) were 65.5% and 58.2%, respectively. The univariate for OS and DFS showed statistically different hazard ratios for conditioning intensity, response pre-alloSCT, comorbidity index, donor/receptor cytomegalovirus status and Eastern Cooperative Oncology Group (ECOG) pre-alloSCT, but only a better ECOG pre-alloSCT remained significant in the multivariate analysis. There was an increased incidence of relapse in those patients who did not develop chronic graft-versus-host disease (GVHD) and an increased risk of death in those developing moderate to severe acute GVHD. The 1-year nonrelapse mortality was 21.9% and was mainly due to GVHD (30%) and bacterial infections (17%). When comparing unrelated donors with haploidentical donors, we found similar results in terms of OS and DFS. There was, however, a reduction of acute GVHD in the haploidentical group (P = .04) and trend to a reduction of chronic GVHD. In conclusion, alloSCT is the only curative option for most aggressive T cell neoplasias. Haploidentical donors offer similar results to related donors in terms of survival with a reduction of acute GVHD

Allogeneic stem cell transplantation as a curative option in relapse/refractory diffuse large B cell lymphoma: Spanish multicenter GETH/GELTAMO study

Grupo Español de Trasplante Hematopoyético (GETH) and Grupo Español de Linfoma y Trasplante Autólogo (GELTAMO).We performed a retrospective multicenter study including 140 patients with relapsed/refractory (R/R) diffuse large B cell lymphoma (DLBCL) who underwent allogeneic hematopoietic stem cell transplantation (allo-SCT) from March 1995 to November 2018. Our objective was to analyze long term outcomes. Seventy-four percent had received a previous auto-SCT (ASCT) and the median number of lines pre-allo-SCT was 3 (range 1–9). Three year-event free survival (EFS) and overall survival (OS) were 38% and 44%, respectively. Non-relapse mortality (NRM) at day 100 was 19%. Cumulative incidence of grade III–IV acute graft versus host disease (GVHD) at day 100 was 16% and moderate/severe chronic GVHD at 3 years 34%. Active disease at allo-SCT (HR 1.95, p = 0.039) (HR 2.19, p = 0.019), HCT-CI ≥ 2 (2.45, p = 0.002) (HR 2.33, p = 0.006) and donor age >37 years (HR 2.75, p = 0.014) (HR 1.98, p = 0.043) were the only independent variables both for PFS and OS, respectively. NRM was significantly modified by HCT-CI ≥ 2 (HR 4.8, p = 0.008), previous ASCT (HR 4.4, p = 0.048) and grade III–IV acute GVHD on day 100 (HR 6.13, p = 0.016). Our data confirmed that allo-SCT is a curative option for patients with R/R DLBCL, displaying adequate results for fit patients with chemosensitive disease receiving an allo-SCT from a young donor

Experiencias de vinculación universitaria desde la formación, la intervención social y la investigación (Complexus 10)

La edición revela experiencias universitarias que analizan y proponen soluciones a problemas sociales mediante la acción colectiva. Muestra la fusión de saberes académicos, experiencias de diversos actores y esfuerzos de la sociedad que se entretejen para construir un mundo más justo y más humano.ITESO, A.C

Predictors of clinically significant quality of life impairment in Parkinson’s disease

COPPADIS Study Group.Quality of life (QOL) plays an important role in independent living in Parkinson’s disease (PD) patients, being crucial to know what factors impact QoL throughout the course of the disease. Here we identified predictors of QoL impairment in PD patients from a Spanish cohort. PD patients recruited from 35 centers of Spain from the COPPADIS cohort from January 2016, to November 2017, were followed up during 2 years. Health-related QoL (HRQoL) and global QoL (GQoL) were assessed with the 39-item Parkinson’s disease Questionnaire (PDQ-39) and the EUROHIS-QOL 8-item index (EUROHIS-QOL8), respectively, at baseline (V0) and at 24 months ± 1 month (V2). Clinically significant QoL impairment was defined as presenting an increase (PDQ-39SI) or decrement (EUROHIS-QOL8) at V2 ≥ 10% of the score at baseline (V0). A comparison with a control group was conducted for GQoL. GQoL did not change significantly in PD patients (N = 507; p = 0.686) or in the control group (N = 119; p = 0.192). The mean PDQ-39SI was significantly increased in PD patients (62.7 ± 8.5 years old; 58.8% males; N = 500) by 21.6% (from 16.7 ± 13 to 20.3 ± 16.4; p < 0.0001) at V2. Ninety-three patients (18.6%) presented a clinically significant HRQoL impairment at V2. To be younger (OR = 0.896; 95% CI 0.829–0.968; p = 0.006), to be a female (OR = 4.181; 95% CI 1.422–12.290; p = 0.009), and to have a greater increase in BDI-II (Beck Depression Inventory-II) (OR = 1.139; 95% CI 1.053–1.231; p = 0.001) and NMSS (Non-Motor Symptoms Scale) (OR = 1.052; 95% CI 1.027–1.113; p < 0.0001) total scores from V0 to V2 were associated with clinically significant HRQoL impairment at the 2-year follow-up (Hosmer–Lemeshow test, p = 0.665; R 2 = 0.655). An increase in ≥5 and ≥10 points of BDI-II and NMSS total score at V2 multiplied the probability of presenting clinically significant HRQoL impairment by 5 (OR = 5.453; 95% CI 1.663–17.876; p = 0.005) and 8 (OR = 8.217; 95% CI, 2.975–22.696; p = 0.002), respectively. In conclusion, age, gender, mood, and non-motor impairment were associated with clinically significant HRQoL impairment after the 2-year follow-up in PD patients.Mir P. has received honoraria from AbbVie, Abbott, Allergan, Bial, Merz, UCB and Zambon and have received grants from the Spanish Ministry of Economy and Competitiveness [PI16/01575] co-founded by ISCIII (Subdirección General de Evaluación y Fomento de la Investigación) and by Fondo Europeo de Desarrollo Regional (FEDER), the Consejería de Economía, Innovación, Ciencia y Empleo de la Junta de Andalucía [CVI-02526, CTS-7685], the Consejería de Salud y Bienestar Social de la Junta de Andalucía [PI-0437-2012, PI-0471-2013], the Sociedad Andaluza de Neurología, the Jacques and Gloria Gossweiler Foundation, the Fundación Alicia Koplowitz, the Fundación Mutua Madrileña.Peer reviewe