Experimental Investigation of the Effect of Temperature on Friction Pressure Loss of Polymeric Drilling Fluid Through Vertical Concentric Annulus

Accurate estimation of annular friction pressure loss is necessary to perform drilling and well completion operations without lostcirculation, pipe sticking or more serious well control problems. Determination of friction pressure loss for Newtonian and non-Newtonianfluids has been investigated in several experimental and theoretical works by considering the effects of eccentricity, pipe rotation or pipegeometry. However, there is a gap in the studies about the temperature effect that is important especially in geothermal wells.This study experimentally investigated the effect of temperature on friction pressure loss through vertical concentric annulus by usingwater and the polymer based drilling fluid including Polyanionic Cellulose and Xanthan Gum. Experiments were conducted in flow loophaving 21-ft smooth and concentric annular test section (2.91 in ID casing x 1.85 in OD pipe).The effect of temperature on rheological model parameters, apparent viscosity, Reynolds number was examined. It was found thatconsistency index and yield point were more sensitive to change in temperature than flow behavior index. Also, apparent viscositydecreased exponentially with increasing temperature and this decrease was more obvious in low shear rate values. Then, according toReynolds number – temperature plot, earlier regime transition was observed with increasing temperature.As a result, increasing temperature caused the decrease in friction pressure loss, and temperature effect should be considered in futureexperimental and theoretical studies in order to estimate friction pressure loss in annuli precisely

A Phenomenology of Religion?

This research explores the possibility of a phenomenology of religion that is ontological, founded on Martin Heidegger’s philosophical thought. The research attempts to utilise Heidegger’s formulation of phenomenology as ontology while also engaging in a critical relation with his path of thinking; as a barrier to the phenomenological interpretation of the meaning of Religion. This research formulates Religion as an ontological problem wherein the primary question becomes: how are humans, in our being, able to be religious and thus also able to understand the meaning of ‘religion’ or something like ‘religion’? This study focuses on the problem of foundation; of whether it is possible to provide an adequate foundation for the study of religion(s) via the notion ‘Religion’. Further, this study also aims to explore the problem of methodological foundation; of how preconceptions of the meaning of Religion predetermine how religion(s) and religious phenomena are studied. Finally, this research moves toward the possibility of founding a regional ontological basis for the study of religion(s) insofar as the research explores the ontological ground of Religion as a phenomenon. Due to the exploratory and methodological/foundational emphasis of the research, the thesis is almost entirely preliminary. Herein, the research focuses on three main issues: how the notion of Religion is preconceived, how Heidegger’s phenomenology can be tailored to the phenomenon of Religion, and how philosophical thought (in this case, Pre-Socratic philosophy) discloses indications of the meaning of Religion. Pre-Socratic thought is then utilised as a foundation for a preliminary interpretation of how Religion belongs-to humans in our being. This research provides two interrelated theses: the provision of an interpretation of Religion as an existential phenomenon, and an interpretation of Religion in its ground of being-human. With regard to the former, I argue that Religion signifies a potential relation with the ‘originary ground’ of life as meaningful. Accordingly, the second interpretation discloses the meaning of Religion as grounded in being-human; that for humans in our being, the meaning of life is an intrinsic question/dilemma for us. This being-characteristic, I argue, can be called belief

The pharmacological management of psychiatric comorbidities in patients with epilepsy.

Psychiatric disorders represent a frequent comorbidity in patients with epilepsy affecting quality of life, morbidity and mortality. Evidence-based data on the management of these conditions are limited but a number of recommendations are now available to guide clinical practice. The present paper reviews the pharmacological treatment of psychiatric problems in epilepsy with special attention to data coming from randomised controlled trials (RCTs), pharmacological interactions with AEDs and the issue of seizure worsening during treatment with psychotropic drugs. Epidemiologically or clinically relevant psychiatric conditions are discussed namely mood and anxiety disorders, psychoses and attention deficit hyperactivity disorder

Nitric Oxide Sustains Long-Term Skeletal Muscle Regeneration by Regulating Fate of Satellite Cells Via Signaling Pathways Requiring Vangl2 and Cyclic GMP

Satellite cells are myogenic precursors that proliferate, activate, and differentiate on muscle injury to sustain the regenerative capacity of adult skeletal muscle; in this process, they self-renew through the return to quiescence of the cycling progeny. This mechanism, while efficient in physiological conditions does not prevent exhaustion of satellite cells in pathologies such as muscular dystrophy where numerous rounds of damage occur. Here, we describe a key role of nitric oxide, an important signaling molecule in adult skeletal muscle, on satellite cells maintenance, studied ex vivo on isolated myofibers and in vivo using the α-sarcoglycan null mouse model of dystrophy and a cardiotoxin-induced model of repetitive damage. Nitric oxide stimulated satellite cells proliferation in a pathway dependent on cGMP generation. Furthermore, it increased the number of Pax7+/Myf5− cells in a cGMP-independent pathway requiring enhanced expression of Vangl2, a member of the planar cell polarity pathway involved in the Wnt noncanonical pathway. The enhanced self-renewal ability of satellite cells induced by nitric oxide is sufficient to delay the reduction of the satellite cell pool during repetitive acute and chronic damages, favoring muscle regeneration; in the α-sarcoglycan null dystrophic mouse, it also slowed disease progression persistently. These results identify nitric oxide as a key messenger in satellite cells maintenance, expand the significance of the Vangl2-dependent Wnt noncanonical pathway in myogenesis, and indicate novel strategies to optimize nitric oxide-based therapies for muscular dystrophy. Stem Cells 2012; 30:197–209

Validity of biomarkers of early circulatory impairment to predict outcome: a retrospective analysis

Objectives: The definition of circulatory impairment in the premature infant is controversial. Current research suggests overdiagnosis and overtreatment. We aimed to analyse which biomarkers move clinicians to initiate cardiovascular treatment (CVT). The prognostic capacity for adverse outcome (death and/or moderate-severe brain damage by cranial ultrasound at term equivalent) of these biomarkers was evaluated. Study Design: Retrospective data analysis from preterm infants enrolled in a placebo-controlled trial on dobutamine for low superior vena cava (SVC) flow, who showed normal SVC flow within the first 24 h (not randomized). Five positive biomarkers were considered: MABP 4 mmol/L; BE < −9 mmol/L; SVC flow <51 ml/kg/min. Results: Ninety eight infants formed the study cohort. Thirty six received CVT (2–95 h). Logistic regression models adjusted for gestational age showed a positive association between CVT and the risk of death or moderate-severe abnormal cranial ultrasound at term equivalent [(OR 5.2, 95%CI: 1.8–15.1) p = 0.002]. MABP 4 mmol/L were the most prevalent biomarkers at start of treatment. Low BE, high serum lactate and low SVC flow at first echocardiography showed a trend toward being associated with adverse outcome, although not statistically significant. Conclusions: Low blood pressure and high lactate are the most prevalent biomarkers used for CVT prescription. Lactic acidosis and low SVC flow early after birth showed a trend toward being associated with adverse outcome. These findings support using a combination of biomarkers for inclusion in a placebo-controlled trial on CVT during transitional circulation

Treating attention-deficit/hyperactivity disorder beyond symptom control alone in children and adolescents: a review of the potential benefits of long-acting stimulants

Attention-deficit/hyperactivity disorder (ADHD), one of the most common neuropsychiatric conditions of childhood, often has a chronic course and persists into adulthood in many individuals. ADHD may have a clinically important impact on health-related quality of life in children, a significant impact on parents’ emotional health and interfere with family activities/cohesion. To date, the main targets of ADHD treatment have focused on reducing the severity of symptoms during the school day and improving academic performance. However, the treatment of ADHD should reach beyond symptom control to address the issues of social competencies and improvement of health-related quality of life from the perspectives of individuals with ADHD and their families, to support them in reaching their full developmental potential. Methylphenidate (MPH) is recognised as the first-line choice of pharmacotherapy for ADHD in children and adolescents. This paper focuses on the importance and benefits to child development of ADHD symptom control beyond the school day only, i.e. extending into late afternoon and evening and uses the example of an extended-release MPH formulation (OROS® MPH) to demonstrate the potential benefits of active full day coverage (12 h) with a single daily dose. Concerns of long-term stimulant treatment are also discussed

A microporous six-fold interpenetrated hydrogen-bonded organic framework for highly selective separation of C 2

A unique six-fold interpenetrated hydrogen-bonded organic framework (HOF) has been developed, for the first time, for highly selective separation of C2H4/C2H6 at room temperature and normal pressure