660 research outputs found
Avaliação do conhecimento e das percepções da população a partir de similaridade de grupos em relação ao consumo do pinhão, sistema produtivo e conservação da araucária.
O uso racional de bens e serviços da natureza tem se mostrado cada vez mais importante para as atividades humanas devido as grandes pressões ambientais ocasionadas pelo consumo desenfreado. A Araucaria angustifolia (Bertol.) Kuntze é uma espécie arbórea pertencente floresta ombrófila mista, sua semente é consumida em diversas regiões do país. Porém é uma espécie ameaçada de extinção. O objetivo do trabalho foi avaliar o conhecimento da população sobre a cadeia produtiva do pinhão. Para este estudo foi realizada pesquisa online com 1000 participantes, os resultados agrupados por similaridade e a produção de clusters de análise. Foi possível perceber que grande parte das pessoas que conhecem o pinhão se encontra na região sul e são mulheres. Seu consumo está relacionado com rendas mais altas e maior escolaridade. A maioria dos consumidores não conhece o manejo produtivo.Anais da Reunião Técnica sobre Agroecologia: Agroecologia, Resiliência e Bem Viver, 2021, Pelotas
Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2.
The essential mitotic kinase Aurora A (AURKA) is controlled during cell cycle progression via two distinct mechanisms. Following activation loop autophosphorylation early in mitosis when it localizes to centrosomes, AURKA is allosterically activated on the mitotic spindle via binding to the microtubule-associated protein, TPX2. Here, we report the discovery of AurkinA, a novel chemical inhibitor of the AURKA-TPX2 interaction, which acts via an unexpected structural mechanism to inhibit AURKA activity and mitotic localization. In crystal structures, AurkinA binds to a hydrophobic pocket (the 'Y pocket') that normally accommodates a conserved Tyr-Ser-Tyr motif from TPX2, blocking the AURKA-TPX2 interaction. AurkinA binding to the Y- pocket induces structural changes in AURKA that inhibit catalytic activity in vitro and in cells, without affecting ATP binding to the active site, defining a novel mechanism of allosteric inhibition. Consistent with this mechanism, cells exposed to AurkinA mislocalise AURKA from mitotic spindle microtubules. Thus, our findings provide fresh insight into the catalytic mechanism of AURKA, and identify a key structural feature as the target for a new class of dual-mode AURKA inhibitors, with implications for the chemical biology and selective therapeutic targeting of structurally related kinases.We are grateful for the access and support at beamlines i02, i03 and i04-1 at Diamond Light Source at Harwell, UK (proposal MX9007 and MX9537) and at beamline Proxima1 at the SOLEIL Synchrotron, Gif-sur-Yvette, France. We are grateful for access and support from the X-ray and biophysics facilities (Dept. of Biochemistry) and the screening/imaging facility (MRC Cancer Unit). M.J. was supported by a Cancer Research UK studentship held in the labs of DS and ARV, PS and MR by a Wellcome Trust Strategic Award to ARV and MH, and DJH, BH, AJN and GM by grants from the UK Medical Research Council to ARV.This is the final version of the article. It first appeared from Nature Publishing Group via http://dx.doi.org/10.1038/srep2852
An update on site search activities for SWGO
The Southern Wide-field Gamma-ray Observatory (SWGO) is a project by
scientists and engineers from 14 countries and 78 institutions to design and
build the first wide-field, ground-based gamma-ray observatory in the Southern
Hemisphere, with high duty cycle and covering an energy range rom hundreds of
GeV to the PeV scale. The observatory will cover the Southern sky and aims to
map the Galaxy's large-scale emission, as well as detecting transient and
variable phenomena. The host sites under consideration are at a minimum
altitude of 4400 m.a.s.l. and comprise two types: flat plateaus of at least 1
km for the installation of an array of tank-based water Cherenkov
detectors (WCD), or large natural lakes for the direct deployment of WCD units.
Four South American countries proposed excellent sites to host the observatory
meeting these requirements. Argentina proposed two locations in the Salta
province, Bolivia presented one site in Chacaltaya, Chile two locations within
the Atacama Astronomical Park, and Peru two ground-based locations in the
Arequipa district as well as lakes in the Cuzco region. The SWGO collaboration
is currently conducting a site characterization study, gathering all the
necessary information for site shortlisting and final site selection by the end
of 2023. The process has reached the shortlisting phase, in which primary and
backup sites for each country have been identified. The primary sites were
visited by a team of experts from the collaboration, to investigate and
validate the proposed site characteristics. Here we present an update on these
site selection activities.Comment: In Proceedings of the 2023 ICRC, Nagoya, Japa
MARTA: A high-energy cosmic-ray detector concept with high-accuracy muon measurement
A new concept for the direct measurement of muons in air showers is
presented. The concept is based on resistive plate chambers (RPCs), which can
directly measure muons with very good space and time resolution. The muon
detector is shielded by placing it under another detector able to absorb and
measure the electromagnetic component of the showers such as a water-Cherenkov
detector, commonly used in air shower arrays. The combination of the two
detectors in a single, compact detector unit provides a unique measurement that
opens rich possibilities in the study of air showers.Comment: 11 page
Measurement of the Depth of Maximum of Extensive Air Showers above 10^18 eV
We describe the measurement of the depth of maximum, Xmax, of the
longitudinal development of air showers induced by cosmic rays. Almost four
thousand events above 10^18 eV observed by the fluorescence detector of the
Pierre Auger Observatory in coincidence with at least one surface detector
station are selected for the analysis. The average shower maximum was found to
evolve with energy at a rate of (106 +35/-21) g/cm^2/decade below 10^(18.24 +/-
0.05) eV and (24 +/- 3) g/cm^2/decade above this energy. The measured
shower-to-shower fluctuations decrease from about 55 to 26 g/cm^2. The
interpretation of these results in terms of the cosmic ray mass composition is
briefly discussed.Comment: Accepted for publication by PR
The Pierre Auger Observatory III: Other Astrophysical Observations
Astrophysical observations of ultra-high-energy cosmic rays with the Pierre
Auger ObservatoryComment: Contributions to the 32nd International Cosmic Ray Conference,
Beijing, China, August 201
Operations of and Future Plans for the Pierre Auger Observatory
Technical reports on operations and features of the Pierre Auger Observatory,
including ongoing and planned enhancements and the status of the future
northern hemisphere portion of the Observatory. Contributions to the 31st
International Cosmic Ray Conference, Lodz, Poland, July 2009.Comment: Contributions to the 31st ICRC, Lodz, Poland, July 200
Highlights from the Pierre Auger Observatory
The Pierre Auger Observatory is the world's largest cosmic ray observatory.
Our current exposure reaches nearly 40,000 km str and provides us with an
unprecedented quality data set. The performance and stability of the detectors
and their enhancements are described. Data analyses have led to a number of
major breakthroughs. Among these we discuss the energy spectrum and the
searches for large-scale anisotropies. We present analyses of our X
data and show how it can be interpreted in terms of mass composition. We also
describe some new analyses that extract mass sensitive parameters from the 100%
duty cycle SD data. A coherent interpretation of all these recent results opens
new directions. The consequences regarding the cosmic ray composition and the
properties of UHECR sources are briefly discussed.Comment: 9 pages, 12 figures, talk given at the 33rd International Cosmic Ray
Conference, Rio de Janeiro 201
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