Numerical approach to a low pressure gas-injection scroll compressor

In order to solve problems arising in ordinary heat pump system for pure electric vehicles at ultra-low temperature, a low pressure gas-injection scroll compressor is designed, and a mathematical model is established. Comparison with the experimental results shows good accuracy of the theoretical prediction. Document type: Articl

Near-Space Communications: the Last Piece of 6G Space-Air-Ground-Sea Integrated Network Puzzle

This article presents a comprehensive study on the emerging near-space communications (NS-COM) within the context of space-air-ground-sea integrated network (SAGSIN). Specifically, we firstly explore the recent technical developments of NS-COM, followed by the discussions about motivations behind integrating NS-COM into SAGSIN. To further demonstrate the necessity of NS-COM, a comparative analysis between the NS-COM network and other counterparts in SAGSIN is conducted, covering aspects of deployment, coverage, channel characteristics and unique problems of NS-COM network. Afterwards, the technical aspects of NS-COM, including channel modeling, random access, channel estimation, array-based beam management and joint network optimization, are examined in detail. Furthermore, we explore the potential applications of NS-COM, such as structural expansion in SAGSIN communication, civil aviation communication, remote and urgent communication, weather monitoring and carbon neutrality. Finally, some promising research avenues are identified, including stratospheric satellite (StratoSat) -to-ground direct links for mobile terminals, reconfigurable multiple-input multiple-output (MIMO) and holographic MIMO, federated learning in NS-COM networks, maritime communication, electromagnetic spectrum sensing and adversarial game, integrated sensing and communications, StratoSat-based radar detection and imaging, NS-COM assisted enhanced global navigation system, NS-COM assisted intelligent unmanned system and free space optical (FSO) communication. Overall, this paper highlights that the NS-COM plays an indispensable role in the SAGSIN puzzle, providing substantial performance and coverage enhancement to the traditional SAGSIN architecture.Comment: 28 pages, 8 figures, 2 table

Large spatial variations in diffusive CH4 fluxes from a subtropical coastal reservoir affected by sewage discharge in southeast China

Coastal reservoirs are potentially CH4 emission hotspots owing to their biogeochemical role as the sinks of anthropogenic carbon and nutrients. Yet, the fine-scale spatial variations in CH4 concentrations and fluxes in coastal reservoirs remain poorly understood, hampering an accurate determination of reservoir CH4 budgets. In this study, we examined the spatial variability of diffusive CH4 fluxes and their drivers at a subtropical coastal reservoir in southeast China using high spatial resolution measurements of dissolved CH4 concentrations and physicochemical properties of the surface water. Overall, this reservoir acted as a consistent source of atmospheric CH4, with a mean diffusive flux of 16.1 μmol m–2 h–1. The diffusive CH4 flux at the reservoir demonstrated considerable spatial variations, with the coefficients of variation ranging between 199 and 426% over the three seasons. The shallow water zone (comprising 23% of the reservoir area) had a disproportionately high contribution (56%) to the whole-reservoir diffusive CH4 emissions. Moreover, the mean CH4 flux in the sewage-affected sectors was significantly higher than that in the nonsewage-affected sectors. The results of bootstrap analysis further showed that increasing the sample size from 10 to 100 significantly reduced the relative standard deviation of mean diffusive CH4 flux from 73.7 to 3.4%. Our findings highlighted the role of sewage in governing the spatial variations in reservoir CH4 emissions and the importance of high spatial resolution data to improve the reliability of flux estimates for assessing the contribution of reservoirs to the regional and global CH4 budgets

Can body mass index, waist circumference, waist-hip ratio and waist-height ratio predict the presence of multiple metabolic risk factors in Chinese subjects?

<p>Abstract</p> <p>Background</p> <p>Obesity is associated with metabolic risk factors. Body mass index (BMI), waist circumference, waist-hip ratio (WHR) and waist-height ratio (WHtR) are used to predict the risk of obesity related diseases. However, it has not been examined whether these four indicators can detect the clustering of metabolic risk factors in Chinese subjects.</p> <p>Methods</p> <p>There are 772 Chinese subjects in the present study. Metabolic risk factors including high blood pressure, dyslipidemia, and glucose intolerance were identified according to the criteria from WHO. All statistical analyses were performed separately according to sex by using the SPSS 12.0.</p> <p>Results</p> <p>BMI, waist circumference and WHtR values were all significantly associated with blood pressure, glucose, triglyceride and also with the number of metabolic risk factors in both male and female subjects (all of P < 0.05). According to receiver operating characteristic (ROC) analysis, the area under curve values of BMI, waist circumference and WHtR did not differ in male (0.682 vs. 0.661 vs. 0.651) and female (0.702 vs. 0.671 vs. 0.674) subjects, indicating that the three values could be useful in detecting the occurrence of multiple metabolic risk factors. The appropriate cut-off values of BMI, waist circumference and WHtR to predict the presence of multiple metabolic risk factors were 22.85 and 23.30 kg/m2 in males and females, respectively. Those of waist circumference and WHtR were 91.3cm and 87.1cm, 0.51 and 0.53 in males and females, respectively.</p> <p>Conclusion</p> <p>The BMI, waist circumference and WHtR values can similarly predict the presence of multiple metabolic risk factors in Chinese subjects.</p

Mediator of DNA Damage Checkpoint 1 (MDC1) Contributes to High NaCl-Induced Activation of the Osmoprotective Transcription Factor TonEBP/OREBP

Background: Hypertonicity, such as induced by high NaCl, increases the activity of the transcription factor TonEBP/OREBP whose target genes increase osmoprotective organic osmolytes and heat shock proteins. Methodology: We used mass spectrometry to analyze proteins that coimmunoprecipitate with TonEBP/OREBP in order to identify ones that might contribute to its high NaCl-induced activation. Principal Findings: We identified 20 unique peptides from Mediator of DNA Damage Checkpoint 1 (MDC1) with high probability. The identification was confirmed by Western analysis. We used small interfering RNA knockdown of MDC1 to characterize its osmotic function. Knocking down MDC1 reduces high NaCl-induced increases in TonEBP/OREBP transcriptional and transactivating activity, but has no significant effect on its nuclear localization. We confirm six previously known phosphorylation sites in MDC1, but do not find evidence that high NaCl increases phosphorylation of MDC1. It is suggestive that MDC1 acts as a DNA damage response protein since hypertonicity reversibly increases DNA breaks, and other DNA damage response proteins, like ATM, also associate with TonEBP/OREBP and contribute to its activation by hypertonicity. Conclusions/Significance: MDC1 associates with TonEBP/OREBP and contributes to high NaCl-induced increase of tha

Ebullition was a major pathway of methane emissions from the aquaculture ponds in southeast China

Aquaculture ponds are hotspots of carbon cycling and important anthropogenic sources of the potent greenhouse gas methane (CH4). Despite the importance of CH4 ebullition in aquatic ecosystems, its magnitude and spatiotemporal variations in aquaculture ponds remain poorly understood. In this study, we determined the rates and spatiotemporal variations of ebullitive CH4 emissions from three mariculture ponds during the aquaculture period of two years at a subtropical estuary in southeast China. Our results showed that the mean ebullitive CH4 flux from the studied ponds was 14.9 mg CH4 m−2 h−1 during the aquaculture period and accounted for over 90% of the total CH4 emission, indicating the importance of ebullition as a major CH4 transport mechanism. Ebullitive CH4 emission demonstrated a clear seasonal pattern, with a peak value during the middle stage of aquaculture. Sediment temperature was found to be an important factor influencing the seasonal variations in CH4 ebullition. Ebullitive CH4 fluxes also exhibited considerable spatial variations within the ponds, with 49.7–71.8% of the whole pond CH4 ebullition being detected in the feeding zone where the large loading of sediment organic matter fueled CH4 production. Aquaculture ponds have much higher ebullitive CH4 effluxes than other aquatic ecosystems, which indicated the urgency to mitigate CH4 emission from aquaculture activities. Our findings highlighted that the importance of considering the large spatiotemporal variations in ebullitive CH4 flux in improving the accuracy of large-scale estimation of CH4 fluxes in aquatic ecosystems. Future studies should be conducted to characterize CH4 ebullitive fluxes over a greater number and diversity of aquaculture ponds and examine the mechanisms controlling CH4 ebullition in aquatic ecosystems

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Enhancing therapeutic performance of personalized cancer vaccine via delivery vectors

In recent years, personalized cancer vaccines have gained increasing attention as emerging immunother-apies with the capability to overcome interindividual differences and show great benefits for individual patients in the clinic due to the highly tailored vaccine formulations. A large number of materials have been studied as delivery vectors to enhance the therapeutic performance of personalized cancer vaccines, including artificial materials, engineered microorganisms, cells and cell derivatives. These delivery vec-tors with distinct features are employed to change antigen biodistributions and to facilitate antigen uptake, processing and presentation, improving the strength, velocity, and duration of the immune response when delivered by different strategies. Here, we provide an overview of personalized cancer vaccine delivery vectors, describing their materials, physicochemical properties, delivery strategies and challenges for clinical transformation. (c) 2021 Elsevier B.V. All rights reserved