Virginia Woolf as equilibrist : the moment of vision and the androgynous mind

Current assessments based more upon Virginia Woolf's feminism than upon her novels as literature threaten to make of her a cult-heroine, whose image is now printed upon t-shirts and tote bags. This study asserts, however, that Virginia Woolf's novels reflect her fictive search for a balance between what she called the masculine and the feminine sides of the brain. To the masculine side, she ascribed qualities that are rational, factual, prosaic, practical, and analytical; to the feminine side, the more intuitive, imaginative, poetic, sensitive, and creative characteristics. More important, minds reflecting equilibrium between these "opposing forces" are called "androgynous," and through characters whose minds reflect such balance and wholeness, Virginia Woolf conveys the experience of the moment of vision

Thermal satellite images and boundary layer structures in desert marginal areas

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Understanding epistemological development in first- and second-year chemistry students

Epistemological beliefs—a learner’s perspective about knowledge and the nature of learning—have been found to play a vital role in learning. Much research has been conducted, both in general and in specific fields, to explore epistemological development in college-aged students; however, little of that research has been done specifically in chemistry. Prior research has documented how chemistry-specific epistemological beliefs change as students progress through their study of chemistry. The current research, which uses a qualitative, longitudinal approach, expands upon this work and explores factors, both curricular and extracurricular, that influence the development of students’ epistemological beliefs about learning chemistry. This manuscript specifically focuses on development during students’ study of chemistry during their first and second years

Reduction of circulating cholesterol and apolipoprotein levels during sepsis

Sepsis with multiple organ failure is frequently associated with a substantial decrease of cholesterol levels. This decrease of cholesterol is strongly associated with mortality suggesting a direct relation between inflammatory conditions and altered cholesterol homeostasis. The host response during sepsis is mediated by cytokines and growth factors, which are capable of influencing lipid metabolism. Conversely lipoproteins are also capable of modulating cytokine production during the inflammatory response. Therefore the decrease in circulating cholesterol levels seems to play a crucial role in the pathophysiology of sepsis. In this review the interaction between cytokines and lipid metabolism and its clinical consequences will be discussed

Farmers' attitudes and landscape change: evidence from the abandonment of terraced cultivations on Lesvos, Greece

Agricultural landscapes are the product of the interaction of the natural environment of an area and the practices of its farmers. In this paper, farmers' practices are examined in order to describe and understand processes of landscape change in terraced fields on the island of Lesvos, Greece. We examine the changes of the terraced fields of each farmer and the reasons for these changes, practices concerning the maintenance of terraces and how farmers view this landscape change. The concept of farming systems is used to link farmers' practices at the farm level with changes at the landscape level. Data come from research via questionnaires to farmers in order to record their practices, to explore changes in land use and the landscape elements and the reasons behind these changes, and finally to record their opinions on the landscape change that result. Findings indicate that although farm households in the case study areas depend on farming incomes by very different degrees, they employ similar cultivation and landscape management practices. At the same time, "hobby" farm households may be more prone to abandonment of fields and negligence of landscape elements (here terraces)

The changing face of the Mediterranean: land cover, demography, and environmental change

This paper introduces a special issue on The Changing Face of the Mediterranean: Land Cover, Demography, and Environmental Change, which brings together up-to-date regional or thematic perspectives on major long-term trends in Mediterranean human–environment relations. Particularly, important insights are provided by palynology to reconstruct past vegetation and land cover, and archaeology to establish long-term demographic trends, but with further significant input from palaeoclimatology, palaeofire research and geomorphology. Here, we introduce the rationale behind this pan-Mediterranean research initiative, outline its major sources of evidence and method, and describe how individual submissions work to complement one another

Potent Phototoxicity of Marine Bunker Oil to Translucent Herring Embryos after Prolonged Weathering

Pacific herring embryos (Clupea pallasi) spawned three months following the Cosco Busan bunker oil spill in San Francisco Bay showed high rates of late embryonic mortality in the intertidal zone at oiled sites. Dead embryos developed to the hatching stage (e.g. fully pigmented eyes) before suffering extensive tissue deterioration. In contrast, embryos incubated subtidally at oiled sites showed evidence of sublethal oil exposure (petroleum-induced cardiac toxicity) with very low rates of mortality. These field findings suggested an enhancement of oil toxicity through an interaction between oil and another environmental stressor in the intertidal zone, such as higher levels of sunlight-derived ultraviolet (UV) radiation. We tested this hypothesis by exposing herring embryos to both trace levels of weathered Cosco Busan bunker oil and sunlight, with and without protection from UV radiation. Cosco Busan oil and UV co-exposure were both necessary and sufficient to induce an acutely lethal necrotic syndrome in hatching stage embryos that closely mimicked the condition of dead embryos sampled from oiled sites. Tissue levels of known phototoxic polycyclic aromatic compounds were too low to explain the observed degree of phototoxicity, indicating the presence of other unidentified or unmeasured phototoxic compounds derived from bunker oil. These findings provide a parsimonious explanation for the unexpectedly high losses of intertidal herring spawn following the Cosco Busan spill. The chemical composition and associated toxicity of bunker oils should be more thoroughly evaluated to better understand and anticipate the ecological impacts of vessel-derived spills associated with an expanding global transportation network

Mediterranean landscape change during the Holocene: synthesis, comparison and regional trends in population, land cover and climate

This synthesis paper offers a comparative perspective on how seven different Mediterranean regions, from Iberia and Morocco to the Levant, have been transformed by human and natural agencies during the last ten millennia. It draws on a range of sources of data notably, 1) archaeological site surveys (n=32k) and 14C dates (n=12k) as proxies for long-term population change, 2) pollen records as a proxy for past vegetation and land cover (n=157), and 3) proxies, such as stable isotopes, from lake, cave and marine records as indicators of hydro-climate (n=47). Where possible, these data sets have been made spatially and temporally congruent in order to examine relationships between them statistically and graphically. Data have been aggregated or averaged for each region/subregion and put into 200-year time windows. Archaeo-demographic data show a clear increase at the start of Neolithic farming, followed by a series of regionally-asynchronous fluctuations in population, prior to a pan-Mediterranean Roman settlement maximum. Pollen data indicate a Late Holocene decline in %Arboreal Pollen in those regions that were initially well-wooded, but not in drier regions of the southern/eastern Mediterranean. Overall, the clearest palynological proxy for human land cover change is provided by the OJCV (tree crop) index. The cultivation of these trees in the eastern Mediterranean after 6500 Cal yr BP may have been an adaptive response to mid-Holocene climatic desiccation. These anthropogenic pollen indicators correlate more closely with trends in population than with regional hydro-climatic z-scores, implying that they reflect primarily human activities. During the mid-Holocene, most Mediterranean landscapes were transformed by a combination of climate and rural land use, but after ~3500 Cal yr BP, human actions became increasingly dominant in determining land cover. During the last 1500 years the dominant landscape trajectory in the eastern Mediterranean was markedly different to that in the central/western Mediterranean

Structural Basis for Broad Neutralization of Hepatitis C Virus Quasispecies

Monoclonal antibodies directed against hepatitis C virus (HCV) E2 protein can neutralize cell-cultured HCV and pseudoparticles expressing envelopes derived from multiple HCV subtypes. For example, based on antibody blocking experiments and alanine scanning mutagenesis, it was proposed that the AR3B monoclonal antibody recognized a discontinuous conformational epitope comprised of amino acid residues 396–424, 436–447, and 523–540 of HCV E2 envelope protein. Intriguingly, one of these segments (436–447) overlapped with hypervariable region 3 (HVR3), a domain that exhibited significant intrahost and interhost genetic diversity. To reconcile these observations, amino-acid sequence variability was examined and homology-based structural modelling of E2 based on tick-borne encephalitis virus (TBEV) E protein was performed based on 413 HCV sequences derived from 18 subjects with chronic hepatitis C. Here we report that despite a high degree of amino-acid sequence variability, the three-dimensional structure of E2 is remarkably conserved, suggesting broad recognition of structural determinants rather than specific residues. Regions 396–424 and 523–540 were largely exposed and in close spatial proximity at the surface of E2. In contrast, region 436–447, which overlaps with HVR3, was >35 Å away, and estimates of buried surface were inconsistent with HVR3 being part of the AR3B binding interface. High-throughput structural analysis of HCV quasispecies could facilitate the development of novel vaccines that target conserved structural features of HCV envelope and elicit neutralizing antibody responses that are less vulnerable to viral escape

The evolution and storage of primitive melts in the Eastern Volcanic Zone of Iceland: the 10 ka Grímsvötn tephra series (i.e. the Saksunarvatn ash)

Major, trace and volatile elements were measured in a suite of primitive macrocrysts and melt inclusions from the thickest layer of the 10 ka Grímsvötn tephra series (i.e. Saksunarvatn ash) at Lake Hvítárvatn in central Iceland. In the absence of primitive tholeiitic eruptions (MgO > 7 wt.%) within the Eastern Volcanic Zone (EVZ) of Iceland, these crystal and inclusion compositions provide an important insight into magmatic processes in this volcanically productive region. Matrix glass compositions show strong similarities with glass compositions from the AD 1783–84 Laki eruption, confirming the affinity of the tephra series with the Grímsvötn volcanic system. Macrocrysts can be divided into a primitive assemblage of zoned macrocryst cores (An_78–An_92, Mg#_cpx = 82–87, Fo_79.5–Fo_87) and an evolved assemblage consisting of unzoned macrocrysts and the rims of zoned macrocrysts (An_60–An_68, Mg#_cpx = 71–78, Fo_70–Fo_76). Although the evolved assemblage is close to being in equilibrium with the matrix glass, trace element disequilibrium between primitive and evolved assemblages indicates that they were derived from different distributions of mantle melt compositions. Juxtaposition of disequilibrium assemblages probably occurred during disaggregation of incompatible trace element-depleted mushes (mean La/Yb_melt = 2.1) into aphyric and incompatible trace element-enriched liquids (La/Yb_melt = 3.6) shortly before the growth of the evolved macrocryst assemblage. Post-entrapment modification of plagioclase-hosted melt inclusions has been minimal and high-Mg# inclusions record differentiation and mixing of compositionally variable mantle melts that are amongst the most primitive liquids known from the EVZ. Coupled high field strength element (HFSE) depletion and incompatible trace element enrichment in a subset of primitive plagioclase-hosted melt inclusions can be accounted for by inclusion formation following plagioclase dissolution driven by interaction with plagioclase-undersaturated melts. Thermobarometric calculations indicate that final crystal-melt equilibration within the evolved assemblage occurred at ~1140°C and 0.0–1.5 kbar. Considering the large volume of the erupted tephra and textural evidence for rapid crystallisation of the evolved assemblage, 0.0–1.5 kbar is considered unlikely to represent a pressure of long-term magma accumulation and storage. Multiple thermometers indicate that the primitive assemblage crystallised at high temperatures of 1240–1300°C. Different barometers, however, return markedly different crystallisation depth estimates. Raw clinopyroxene-melt pressures of 5.5–7.5 kbar conflict with apparent melt inclusion entrapment pressures of 1.4 kbar. After applying a correction derived from published experimental data, clinopyroxene-melt equilibria return mid-crustal pressures of 4±1.5 kbar, which are consistent with pressures estimated from the major element content of primitive melt inclusions. Long-term storage of primitive magmas in the mid-crust implies that low CO_2 concentrations measured in primitive plagioclase-hosted inclusions (262–800 ppm) result from post-entrapment CO_2 loss during transport through the shallow crust. In order to reconstruct basaltic plumbing system geometries from petrological data with greater confidence, mineral-melt equilibrium models require refinement at pressures of magma storage in Iceland. Further basalt phase equilibria experiments are thus needed within the crucial 1–7 kbar range.D.A.N. was supported by a Natural Environment Research Council studentship (NE/1528277/1) at the start of this project. SIMS analyses were supported by Natural Environment Research Council Ion Microprobe Facility award (IMF508/1013).This is the final version of the article. It first appeared from Springer via http://dx.doi.org/10.1007/s00410-015-1170-