313 research outputs found
Minimal resources for linear optical one-way computing
We address the question of how many maximally entangled photon pairs are
needed in order to build up cluster states for quantum computing using the
toolbox of linear optics. As the needed gates in dual-rail encoding are
necessarily probabilistic with known optimal success probability, this question
amounts to finding the optimal strategy for building up cluster states, from
the perspective of classical control. We develop a notion of classical
strategies, and present rigorous statements on the ultimate maximal and minimal
use of resources of the globally optimal strategy. We find that this strategy -
being also the most robust with respect to decoherence - gives rise to an
advantage of already more than an order of magnitude in the number of maximally
entangled pairs when building chains with an expected length of L=40, compared
to other legitimate strategies. For two-dimensional cluster states, we present
a first scheme achieving the optimal quadratic asymptotic scaling. This
analysis shows that the choice of appropriate classical control leads to a very
significant reduction in resource consumption.Comment: 5 pages, 2 figures, title changed, presentation improved, bounds
improved, minor errors corrected, references update
Revised Phase Diagram of the Gross-Neveu Model
We confirm earlier hints that the conventional phase diagram of the discrete
chiral Gross-Neveu model in the large N limit is deficient at non-zero chemical
potential. We present the corrected phase diagram constructed in mean field
theory. It has three different phases, including a kink-antikink crystal phase.
All transitions are second order. The driving mechanism for the new structure
of baryonic matter in the Gross-Neveu model is an Overhauser type instability
with gap formation at the Fermi surface.Comment: Revtex, 12 pages, 15 figures; v2: Axis labelling in Fig. 9 correcte
The phase diagram of the massive Gross-Neveu model, revisited
The massive Gross-Neveu model is solved in the large N limit at finite
temperature and chemical potential. The phase diagram features a kink-antikink
crystal phase which was missed in previous works. Translated into the framework
of condensed matter physics our results generalize the bipolaron lattice in
non-degenerate conducting polymers to finite temperature.Comment: revtex, 4 pages, 3 figures; v2: minor typos corrected; v3: minor
corrections concerning figures 2 and
Emotion repair and the direction of attention in aversive contexts: Evidence from an attention-demanding task
Two studies (total N = 145) examined the novel idea that individual differences in emotion repair may relate to the attention deployment stage of emotion regulation. More specifically, it was hypothesized that high repair individuals would be able to maintain focus on an attention-demanding task in an aversive context, but that low repair individuals would not, in both cases relative to a control condition. This sort of interactive hypothesis was supported in Study 1, which manipulated aversive events through the use of concurrent auditory stimulation and conceptual replication was found in Study 2. Together, the two studies offer suggestive evidence for the role of attention direction in emotion repair
MeCP2 Regulates the Synaptic Expression of a Dysbindin-BLOC-1 Network Component in Mouse Brain and Human Induced Pluripotent Stem Cell-Derived Neurons
Clinical, epidemiological, and genetic evidence suggest overlapping pathogenic mechanisms between autism spectrum disorder (ASD) and schizophrenia. We tested this hypothesis by asking if mutations in the ASD gene MECP2 which cause Rett syndrome affect the expression of genes encoding the schizophrenia risk factor dysbindin, a subunit of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), and associated interacting proteins. We measured mRNA and protein levels of key components of a dysbindin interaction network by, quantitative real time PCR and quantitative immunohistochemistry in hippocampal samples of wild-type and Mecp2 mutant mice. In addition, we confirmed results by performing immunohistochemistry of normal human hippocampus and quantitative qRT-PCR of human inducible pluripotent stem cells (iPSCs)-derived human neurons from Rett syndrome patients. We defined the distribution of the BLOC-1 subunit pallidin in human and mouse hippocampus and contrasted this distribution with that of symptomatic Mecp2 mutant mice. Neurons from mutant mice and Rett syndrome patients displayed selectively reduced levels of pallidin transcript. Pallidin immunoreactivity decreased in the hippocampus of symptomatic Mecp2 mutant mice, a feature most prominent at asymmetric synapses as determined by immunoelectron microcopy. Pallidin immunoreactivity decreased concomitantly with reduced BDNF content in the hippocampus of Mecp2 mice. Similarly, BDNF content was reduced in the hippocampus of BLOC-1 deficient mice suggesting that genetic defects in BLOC-1 are upstream of the BDNF phenotype in Mecp2 deficient mice. Our results demonstrate that the ASD-related gene Mecp2 regulates the expression of components belonging to the dysbindin interactome and these molecular differences may contribute to synaptic phenotypes that characterize Mecp2 deficiencies and ASD.Fil: Larimore, Jennifer. Agnes Scott College; Estados UnidosFil: Ryder, Pearl V.. University of Emory; Estados UnidosFil: Kim, Kun Yong. University of Yale. School of Medicine; Estados UnidosFil: Ambrose, L. Alex. Agnes Scott College; Estados UnidosFil: Chapleau, Christopher. University Of Alabama; Estados UnidosFil: Calfa, Gaston Diego. University Of Alabama; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gross, Christina. University of Emory; Estados UnidosFil: Bassell, Gary J.. University of Emory; Estados UnidosFil: Pozzo Miller, Lucas. University Of Alabama; Estados UnidosFil: Smith, Yoland. University of Emory; Estados UnidosFil: Talbot, Konrad. The Pennsylvania State University; Estados UnidosFil: Park, In Hyun. University of Yale. School of Medicine; Estados UnidosFil: Faundez, Victor. University of Emory; Estados Unido
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Regional modelling of Saharan dust and biomass-burning smoke, Part I: Model description and evaluation
The spatio-temporal evolution of the Saharan dust and biomass-burning plume during the SAMUM-2 field campaign
in January and February 2008 is simulated at 28 km horizontal resolution with the regional model-system COSMOMUSCAT.
The model performance is thoroughly tested using routine ground-based and space-borne remote sensing
and local field measurements. Good agreement with the observations is found in many cases regarding transport
patterns, aerosol optical thicknesses and the ratio of dust to smoke aerosol. The model also captures major features
of the complex aerosol layering. Nevertheless, discrepancies in the modelled aerosol distribution occur, which are
analysed in detail. The dry synoptic dynamics controlling dust uplift and transport during the dry season are well
described by the model, but surface wind peaks associated with the breakdown of nocturnal low-level jets are not
always reproduced. Thus, a strong dust outbreak is underestimated. While dust emission modelling is a priori more
challenging, since strength and placement of dust sources depend on on-line computed winds, considerable inaccuracies
also arise in observation-based estimates of biomass-burning emissions. They are caused by cloud and spatial errors of
satellite fire products and uncertainties in fire emission parameters, and can lead to unrealistic model results of smoke
transport
Cytogenetic and histological studies of the brook trout, Salvelinus fontinalis (Mitchill), and the Arctic char, S-alpinus (L.) hybrids
Although brook trout and the Arctic char hybrids are able to reproduce, individuals with decreased fertility or even fish that are unable to produce any gametes have been also described. Abnormal gonadal development and disturbances in the gamete production in the char hybrid offspring may be triggered by the odd chromosome number and disturbances in their pairing during meiosis. To verify this hypothesis, cytogenetic examination and the gonadal histology analysis of the brook trout x Arctic char hybrids were carried out. Diploid chromosome number in the studied char (F-1) hybrids varied from 82 to 84 (FN = 99-102). Among 28 hybrids, 12 males, three females, nine intersex individuals and two sterile specimens were described. In the case of two individuals, gonads were not found. Diploid chromosome numbers in the males and intersex individuals varied from 82 to 84. Chromosome numbers in the females were 82 and 83 chromosomes. Two sterile fish exhibited karyotypes composed of 82 and 84 chromosomes. Predominance of the ovarian component in the intersex gonads and gonadal sex ratio distortion towards the males suggested hybrid females had problems with gonadal differentiation. However, the lack of the clear relationship between chromosome number and gonadal development in the studied hybrids did not support our hypothesis that odd chromosome number may be responsible for such reproductive disturbances in the hybrid individuals. We have presumed that sterility and intersexual development of the gonads may be caused by interactions between brook trout and Arctic char genes on the sex chromosomes and autosomes rather than unpairing of the parental chromosomes.Polish National Science Center (NCN) [N N311 525240]info:eu-repo/semantics/publishedVersio
Diversity and uniformity in genetic responsibility: moral attitudes of patients, relatives and lay people in Germany and Israel
The professional and institutional responsibility for handling genetic knowledge is well discussed; less attention has been paid to how lay people and particularly people who are affected by genetic diseases perceive and frame such responsibilities. In this exploratory study we qualitatively examine the attitudes of lay people, patients and relatives of patients in Germany and Israel towards genetic testing. These attitudes are further examined in the national context of Germany and Israel, which represent opposite regulatory approaches and bioethical debates concerning genetic testing. Three major themes of responsibility emerged from the inter-group and cross-cultural comparison: self-responsibility, responsibility for kin, and responsibility of society towards its members. National contrast was apparent in the moral reasoning of lay respondents concerning, for example, the right not to know versus the duty to know (self-responsibility) and the moral conflict concerning informing kin versus the moral duty to inform (responsibility for kin). Attitudes of respondents affected by genetic diseases were, however, rather similar in both countries. We conclude by discussing how moral discourses of responsibility are embedded within cultural (national, religious) as well as phenomenological (being affected) narratives, and the role of public engagement in bioethical discourse
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