667 research outputs found
The Line Emission Region in III Zw 2: Kinematics and Variability
We have studied the Ly-al, Hbeta, Halpha and Mg II2798 line profiles of the
Seyfert 1 galaxy III Zw 2. The shapes of these broad emission lines show
evidence of a multicomponent origin and also features which may be identified
as the peaks due to a rotating disk. We have proposed a two-component Broad
Line Region (BLR) model consisting of an inner Keplerian relativistic disk and
an outer structure surrounding the disk. The results of the fitting of the four
Broad Emission Lines (BELs) here considered, are highly consistent in both the
inner and outer component parameters. Adopting a mass of approx. 2 E8 sollar
masses for the central object we found that the outer radius of the disk is
approximately equal for the four considered lines (approx 0.01 pc). However,
the inner radius of the disk is not the same: 0.0018 pc for Ly-alpha, 0.0027 pc
for Mg II, and 0.0038 pc for the Balmer lines. This as well as the relatively
broad component present in the blue wings of the narrow [OIII] lines indicate
stratification in the emission-line region. Using long-term Hbeta observations
(1972-1990, 1998) we found a flux variation of the BEL with respect to the
[OIII] lines.Comment: ApJ, accepted, 22 pages, 10 figure
Translational and Regulatory Challenges for Exon Skipping Therapies
Several translational challenges are currently impeding the therapeutic development of antisense-mediated exon skipping approaches for rare diseases. Some of these are inherent to developing therapies for rare diseases, such as small patient numbers and limited information on natural history and interpretation of appropriate clinical outcome measures. Others are inherent to the antisense oligonucleotide (AON)-mediated exon skipping approach, which employs small modified DNA or RNA molecules to manipulate the splicing process. This is a new approach and only limited information is available on long-term safety and toxicity for most AON chemistries. Furthermore, AONs often act in a mutation-specific manner, in which case multiple AONs have to be developed for a single disease. A workshop focusing on preclinical development, trial design, outcome measures, and different forms of marketing authorization was organized by the regulatory models and biochemical outcome measures working groups of Cooperation of Science and Technology Action: "Networking towards clinical application of antisense-mediated exon skipping for rare diseases." The workshop included participants from patient organizations, academia, and members of staff from the European Medicine Agency and Medicine Evaluation Board (the Netherlands). This statement article contains the key outcomes of this meeting.status: publishe
Short-term emission line and continuum variations in Mrk110
We present results of a variability campaign of Mrk110 performed with the
9.2-m Hobby-Eberly Telescope (HET) at McDonald Observatory. The high S/N
spectra cover most of the optical range. They were taken from 1999 November
through 2000 May. The average interval between the observations was 7.3 days
and the median interval was only 3.0 days. Mrk110 is a narrow-line Seyfert 1
galaxy. During our campaign the continuum flux was in a historically low stage.
Considering the delays of the emission lines with respect to the continuum
variations we could verify an ionization stratification of the BLR. We derived
virial masses of the central black hole from the radial distances of the
different emission lines and from their widths. The calculated central masses
agree within 20%. Furthermore, we identified optical HeI singlet emission lines
emitted in the broad-line region. The observed line fluxes agree with
theoretical predictions. We show that a broad wing on the red side of the
[OIII]5007 line is caused by the HeI singlet line at 5016A.Comment: 11 pages, 16 figures, A&A Latex. Accepted for publication in A&A Main
Journa
Ultraviolet and optical properties of Narrow-Line Seyfert 1 galaxies
Narrow Line Seyfert 1 (NLS1) galaxies are remarkable for their extreme
continuum and emission line properties which are not well understood. New
results bearing on the spectroscopic characteristics of these objects are
presented here, with the aim of establishing their typical ultraviolet and
optical spectral behavior. We employ HST observations of 22 NLS1s, which
represent a substantial improvement over previous work in terms of data quality
and sample size. High signal-to-noise NLS1 composite spectra are constructed,
allowing accurate measurements of the continuum shape and the strengths,
ratios, and widths for lines, including weak features which are barely
identifiable in other Active Galactic Nuclei (AGN) composites. We find that the
NLS1 sources have redder UV-blue continua than those typically measured in
other quasars and Seyferts. Objects with UV line absorption show redder
spectra, suggesting that dust is important in modifying the continuum shapes.
The data also permit a detailed investigation of the previously proposed link
between NLS1s and z >~ 4 quasars. Direct comparison of their composite spectra,
as well as a Principal Component Analysis, suggest that high-z QSOs do not show
a strong preference toward NLS1 behavior.Comment: 23 pages (incl. 9 figures, 4 tables), to appear in The Publications
of the Astronomical Society of the Pacifi
The UV Properties of the Narrow Line Quasar I Zwicky 1
I Zw 1 is the prototype narrow line quasar. We report here the results of our
study of the UV emission of I Zw 1 using a high S/N (50-120) spectrum obtained
with the HST FOS. The following main new results are obtained: 1. The Mg II and
Al III doublets are partially/fully resolved. The measured doublet ratios
verify theoretical predictions that the lines are thermalized in the BLR. 2. A
weak associated UV absorption system is detected in N~V, and possibly also in C
IV and Lya, suggesting an outflow with a velocity of 1870 km/s and velocity
dispersion <300 km/s. 3. Lines from ions of increasing ionization level show
increasing excess blue wing flux, and an increasing line peak velocity shift,
reaching a maximum blueshift of about 2000 km/s for He II 1640. This may
indicate an out-flowing component in the BLR, where the ionization level
increases with velocity, and which is visible only in the approaching
direction. The highest velocity part of this outflow may produce the associated
UV absorption system. 4. The small C III] 1909 EW, and the small C III]
1909/Lya and C III] 1909/Si III] 1892 flux ratios indicate a typical BLR
density of 10^11, i.e. about an order of magnitude larger than implied by C
III] 1909 in most quasars. A BLR component of a higher density is implied by
the EW and doublet ratio of the Al III 1857 doublet. 5. Prominent Fe II UV 191
emission is seen, together with weaker line emission at 1294 and 1871 A. These
three features have been proposed as evidence for significant Lya pumping of
the 8-10 eV levels of Fe II. 6. Significant Fe III emission is present. The Fe
III UV 34 and UV 48 multiplets are clearly resolved, and Fe III UV 1, UV 47, UV
50, and UV 68 may also be present. (Shortened version)Comment: 28 pages, 1 table and 7 figures included. Uses aas2pp4.sty. Scheduled
for the Astrophysical Journal November 10, 1997 issue, Vol. 48
An Empirical Ultraviolet Template for Iron Emission in Quasars as Derived from I Zw 1
We present an empirical template spectrum suitable for fitting/subtracting
and studying the FeII and FeIII line emission in the restframe UV spectra of
active galatic nuclei (AGNs), the first empirical UV iron template to cover the
full 1250 - 3090 A range. Iron emission is often a severe contaminant in
optical--UV spectra of AGNs. Its presence complicates and limits the accuracy
of measurements of both strong and weak emission lines and the continuum
emission, affecting studies of line and continuum interrelations, the
ionization structure, and elemental abundances in AGNs. Despite the wealth of
work on modeling the AGN FeII emission and the need to account for it in
observed AGN spectra, there is no UV template electronically available to aid
this process. The iron template we present is based on HST spectra of the
Narrow Line Seyfert 1, IZw1. Its intrinsic narrow lines (~900 km/s) and rich
iron spectrum make the template particularly suitable for use with most AGN
spectra. The iron emission spectrum and the line identifications and
measurements are presented and compared with the work of Laor et al. We
illustrate the application of the derived FeII and FeIII templates by fitting
and subtracting the iron emission from UV spectra of four high-z quasars and of
the nearby quasar, 3C273. We briefly discuss the small discrepancies between
this observed iron emission and the UV template, and compare the template with
previously published ones. We discuss the advantages and limitations of the
templates and of the template fitting method. We conclude that the templates
work sufficiently well to be a valuable and important tool for eliminating and
studying the iron emission in AGNs, at least until accurate theoretical iron
emission models are developed. (Abridged)Comment: 73 pages including 7 figures, 6 tables. To appear in ApJS. Preprint
is also available at
http://www.astronomy.ohio-state.edu/~vester/IronEmission
CD4-positive T cells and M2 macrophages dominate the peritoneal infiltrate of patients with encapsulating peritoneal sclerosis
Background
Encapsulating peritoneal sclerosis (EPS) is a severe complication of peritoneal dialysis (PD). Previously, it has been shown that infiltrating CD4-positive T cells and M2 macrophages are associated with several fibrotic conditions. Therefore, the characteristics of the peritoneal cell infiltrate in EPS may be of interest to understand EPS pathogenesis. In this study, we aim to elucidate the composition of the peritoneal cell infiltrate in EPS patients and relate the findings to clinical outcome.
Study Design, Setting, and Participants
We studied peritoneal membrane biopsies of 23 EPS patients and compared them to biopsies of 15 PD patients without EPS. The cellular infiltrate was characterized by immunohistochemistry to detect T cells(CD3-positive), CD4-positive (CD4+) and CD8-positive T cell subsets, B cells(CD20-positive), granulocytes(CD15-positive), macrophages(CD68-positive), M1(CD80-positive), and M2(CD163-positive) macrophages. Tissues were analysed using digital image analysis. Kaplan-Meier survival analysis was performed to investigate the survival in the different staining groups.
Results
The cellular infiltrate in EPS biopsies was dominated by mononuclear cells. For both CD3 and CD68, the median percentage of area stained was higher in biopsies of EPS as opposed to non-EPS patients (p<0.001). EPS biopsies showed a higher percentage of area stained for CD4 (1.29%(0.61-3.20)) compared to CD8 (0.71%(0.46-1.01), p = 0.04), while in the non-EPS group these cells were almost equally represented (respectively 0.28% (0.05-0.83) versus 0.22%(0.17-0.43), p = 0.97). The percentage of area stained for both CD80 and CD163 was higher in EPS than in non-EPS biopsies (p<0.001), with CD163+ cells being the most abundant phenotype. Virtually no CD20-positive and CD15-positive cells were present in biopsies of a subgroup of EPS patients. No relation was found between the composition of the mononuclear cell infiltrate and clinical outcome.
Conclusions
A characteristic mononuclear cell infiltrate consisting of CD4+ and CD163+ cells dominates the peritoneum of EPS patients. These findings suggest a role for both CD4+ T cells and M2 macrophages in the pathogenesis of EPS
Long-term variability of the optical spectra of NGC 4151: I. Light curves and flux correlations
Results of a long-term spectral monitoring of the active galactic nucleus of
NGC 4151 are presented (11 years, from 1996 to 2006). High quality spectra
(S/N>50 in the continuum near Halpha and Hbeta) were obtained in the spectral
range ~4000 to 7500 \AA, with a resolution between 5 and 15 A, using the 6-m
and the 1-m SAO's telescopes (Russia), the GHAO's 2.1-m telescope (Cananea,
Mexico), and the OAN-SPM's 2.1-m telescope (San-Pedro, Mexico). The observed
fluxes of the Halpha, Hbeta, Hgamma and HeII emission lines and of the
continuum at the observed wavelength 5117 A, were corrected for the position
angle, the seeing and the aperture effects.
We found that the continuum and line fluxes varied strongly (up to a factor
6) during the monitoring period. The emission was maximum in 1996-1998, and
there were two minima, in 2001 and in 2005. The Halpha, Hgamma and He II fluxes
were well correlated with the Hbeta flux. We considered three characteristic
periods during which the Hbeta and Halpha profiles were similar: 1996-1999,
2000-2001 and 2002-2006. The line to continuum flux ratios were different; in
particular during the first period, the lines were not correlated with the
continuum and saturated at high fluxes. In the second and third period, where
the continuum flux was small, the Halpha and Hbeta fluxes were well correlated
to the continuum flux, meaning that the ionizing continuum was a good
extrapolation of the optical continuum. The CCFs are often asymmetrical and the
time lags between the lines and the continuum are badly defined indicating the
presence of a complex BLR, with dimensions from 1 to 50 light-days.Comment: A&A, accepte
Multiwavelength Monitoring of the Narrow-Line Seyfert 1 Galaxy Akn 564. II. Ultraviolet Continuum and Emission-line Variability
We present results of an intensive two-month campaign of approximately daily
spectrophotometric monitoring of the narrow-line Seyfert 1 galaxy Akn 564 with
HST. The fractional variability amplitude of the continuum variations between
1365-3000 A is ~6%, about a factor 3 less than that found in typical Seyfert 1
galaxies over a similar period of time. However, large amplitude, short
time-scale flaring behavior is evident, with trough-to-peak flux changes of
about 18% in approximately 3 days. We present evidence for wavelength-dependent
continuum time delays, with the variations at 3000 A lagging behind those at
1365 A by about 1 day. These delays may be interpreted as evidence for a
stratified continuum reprocessing region, possibly an accretion-disk structure.
The Lyman-alpha 1216 emission-line exhibits flux variations of about 1%
amplitude.Comment: 27 pages, 14 figures. Accepted by Astrophysical Journa
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