Antagonistic and plant growth promoting properties of actinomycetes from rhizosphere Deschampsia antarctica È. Desv. (Galindez Island, Antarctica)

Aim. The isolation of actinomycetes from Deschampsia antarctica É. Desv. (Galindez Island, Antarctica) rhisosphere and determine their ability to produce compounds with antimicrobial and plant growth promotional properties.Мета. Виділення актиноміцетів з ризосфери Deschampsia antarctica É. Desv. популяцій антарктичного острова Галіндез, оцінка їхньої здатності пригнічувати фітопатогенні мікроорганізми і продукувати фітостимулювальні сполуки

PORTABLE GAMMA CAMERA. CHOICE AND CALCULATION OF COLLIMATORS

This work is theoretical and intended to expand the diagnostic capabilities of the gamma camera by development the portable gamma camera. The choice of suitable collimators is discussed in the work. There were carried out the calculations for different types of collimators based on the needs of physicians

WAYS TO PREVENT SUPPURATIVE AND INFLAMMATORY COMPLICATIONS OF ABDOMINAL CAVITY IN PATIENTS WITH CHRONIC PANCREATITIS AT THE ORGAN-PRESERVING PANCREATIC HEAD RESECTION

The aim. of the study was to improve organ-preserving pancreatic head resection in patients with chronic pancreatitis due to application of developed methods that eliminate the pain, common bile duct obstruction, duodenal stenosis, and involvement of major retropancreatic intestinal vessels that prevent the development of inflammatory, infiltrative and septic complications of abdominal cavity. With the use of developed techniques we operated 30 patients. The results of clinical studies and additional tool researches confirmed the effectiveness of methods for addressing the underlying symptoms, clinical manifestations of chronic pancreatitis and prevention of inflammatory, infiltrative and disseminated septic complications of abdominal cavity

ЧИСЛЕННОЕ ИССЛЕДОВАНИЕ СТРУКТУРЫ МАГНИТНОГО ПОЛЯ В ЦИЛИНДРИЧЕСКОМ ПЛЕНОЧНОМ ЭКРАНЕ

A numerical method for solving the boundary value problem for a nonlinear magnetostatic equation describing the external magnetostatic field penetration through the cylindrical film coating is developed. A mathematical model of the shielding problem based on the use of the boundary conditions of the third kind on the film surface is studied. The nonlinear dependence of the film magnetic permeability on magnetic field conforms with experimental data. The distribution of the magnetic field strength in the film layer and the magnetic permeability of the film material depending on the magnitude of the external magnetic field strength are investigated numerically.Разрабатывается численный метод решения краевой задачи для нелинейного уравнения магнитостатики, описывающей проникновение постоянного внешнего магнитного поля через цилиндрическую пленочную оболочку. Изучается математическая модель задачи экранирования, основанная на использовании граничных условий третьего рода на поверхности пленки. Нелинейная зависимость магнитной проницаемости пленки от напряженности магнитного поля согласовывается с экспериментальными данными. Численно исследуется распределение напряженности магнитного поля в слое пленки и магнитной проницаемости материала пленки в зависимости от величины напряженности внешнего магнитного поля

One Europe or None? Monism, Involution and Relations with Russia

The crisis in relations between Russia and the European Union (EU) is part of the broader breakdown of the post-Cold War security order. This commentary focuses on structural interpretation and identifies four interlinked processes shaping the crisis: tension between the logic of the enlargement and transformation; a dynamic of involution and resistance; the problem of monism, whereby the expanding self is unable adequately to engage with the un-integrated other; and the recent emergence of ‘other Europes’ that may potentially overcome involution. The erosion of the Atlantic system provides an opportunity for delayed institutional and ideational innovation

Not particularly special: critiquing ‘NPS’ as a category of drugs

Novel Psychoactive Substances (NPS) have been a dominant feature of drug discourse for many years now and, in academic, policy and public discourse, have become established as a new – and by implication, distinct – category of drugs. We argue that this understanding of NPS is fundamentally problematic. Differences within the category are obscured, as are similarities between NPS and more established categories of drugs. Focusing on NPS as something new, different or particularly special is misleading and counterproductive and can have serious consequences in terms of understanding the bigger picture in relation to illegal drugs more generally. This has led to overestimations of the size of the NPS problem, obfuscation of the common underlying causes of dependent drug use, and the implementation of significant and problematic policy changes. Further, a failure to see the rise in NPS as just one of a number of emerging trends in contemporary drug scenes, alongside the development of online markets or the rise in domestic drug production operations, for example, impairs our ability to understand the wider societal, cultural and theoretical underpinnings of drug use. NPS are not particularly special: treating them as such can have dangerous and far-reaching consequences

Protein N-terminal acetylation: NAT 2007–2008 Symposia

Protein N-terminal acetylation is a very common modification, but has during the past decades received relatively little attention. In order to put this neglected field back on the scientific map, we have in May 2007 and September 2008 arranged two international NAT symposia in Bergen, Norway. This supplement contains selected proceedings from these symposia reflecting the current status of the field, including an overview of protein N-terminal acetylation in yeast and humans, a novel nomenclature system for the N-terminal acetyltransferases (NATs) and methods for studying protein N-terminal acetylation in vitro and in vivo

NatF Contributes to an Evolutionary Shift in Protein N-Terminal Acetylation and Is Important for Normal Chromosome Segregation

N-terminal acetylation (N-Ac) is a highly abundant eukaryotic protein modification. Proteomics revealed a significant increase in the occurrence of N-Ac from lower to higher eukaryotes, but evidence explaining the underlying molecular mechanism(s) is currently lacking. We first analysed protein N-termini and their acetylation degrees, suggesting that evolution of substrates is not a major cause for the evolutionary shift in N-Ac. Further, we investigated the presence of putative N-terminal acetyltransferases (NATs) in higher eukaryotes. The purified recombinant human and Drosophila homologues of a novel NAT candidate was subjected to in vitro peptide library acetylation assays. This provided evidence for its NAT activity targeting Met-Lys- and other Met-starting protein N-termini, and the enzyme was termed Naa60p and its activity NatF. Its in vivo activity was investigated by ectopically expressing human Naa60p in yeast followed by N-terminal COFRADIC analyses. hNaa60p acetylated distinct Met-starting yeast protein N-termini and increased general acetylation levels, thereby altering yeast in vivo acetylation patterns towards those of higher eukaryotes. Further, its activity in human cells was verified by overexpression and knockdown of hNAA60 followed by N-terminal COFRADIC. NatF's cellular impact was demonstrated in Drosophila cells where NAA60 knockdown induced chromosomal segregation defects. In summary, our study revealed a novel major protein modifier contributing to the evolution of N-Ac, redundancy among NATs, and an essential regulator of normal chromosome segregation. With the characterization of NatF, the co-translational N-Ac machinery appears complete since all the major substrate groups in eukaryotes are accounted for