The Feasibility of the Disturbance Accommodating Controller for Precision Antenna Pointing

The objective of this study is to investigate the feasibility of a pointing (position loop) controller for the NASA-JPL Deep Space Network (DSN) antennas using the Disturbance Accommodating Control (DAC) theory. A model that includes state dependent disturbances was developed, and an example demonstrating the noise estimator is presented as an initial phase in the controller design. The goal is to improve pointing accuracy by the removal of the systematic errors caused by the antenna misalignment as well as sensor noise and random wind and thermal disturbances. Preliminary simulation results show that the DAC technique is successful in both cancelling the imposed errors and maintaining an optimal control policy

Compensator improvement for multivariable control systems

A theory and the associated numerical technique are developed for an iterative design improvement of the compensation for linear, time-invariant control systems with multiple inputs and multiple outputs. A strict constraint algorithm is used in obtaining a solution of the specified constraints of the control design. The result of the research effort is the multiple input, multiple output Compensator Improvement Program (CIP). The objective of the Compensator Improvement Program is to modify in an iterative manner the free parameters of the dynamic compensation matrix so that the system satisfies frequency domain specifications. In this exposition, the underlying principles of the multivariable CIP algorithm are presented and the practical utility of the program is illustrated with space vehicle related examples

Jewell L. Gresham to Dr. Silver, 17 July 1963

Professional correspondenc

An Interprofessional Approach to Teaching Evidence-based Practice

Purpose: The purpose of this mixed methods study was to identify students’ engagement and implementation of EBP competencies after exposure to EBP content in an interprofessional online research course. In this research, a diverse, convenience sample of nursing, respiratory care, and social work students were selected. The results aim to assist educators in preparing the next generation for their first professional role in providing care using the best evidence. The research questions that guided the study were: (1) What are the levels of practice, attitude, knowledge and skill regarding EBP among the sample? (2) What are the barriers and facilitators to acquiring EBP competency? (3) What are the differences in EBP attitudes, knowledge, and skills between the diverse disciplines in the sample? Methods: This descriptive mixed methods study employed a cross sectional design that allowed comparisons of programs and the different levels within the program. Quantitative data was collected using the S-EBPQ survey, allowing participants’ the opportunity to self-report on the practice, attitude, and knowledge/skills. Qualitative data was collected through two focus groups of approximately six to ten students from the three programs. Results: Data showed that students within the three selected disciplines had a positive attitude towards EBP. Theme analysis supported this view as participants noted EBP impacts patient safety and quality care. Barriers identified included, “lack of resources, use of research language interchangeably with EBP, quick exposure to EBP and confusion among EBP practices in the clinical setting.” Participants had an awareness of EBP and recognized the value of EBP. However, there may be ways to improve the implementation of EBP throughout the learning process while students are in undergraduate studies. Conclusion: Using an interprofessional online research course to introduce students to EBP was successful. Providing an interprofessional approach to teaching EBP will provide support the implementation of EBP competencies. Further development of additional interprofessional EBP courses or activities should be considered. This study found that if interprofessional care teams’ work together and use the EBP process in their courses it will improve student perceived value of EBP

Genetic Insights into Aging and Age-Related Diseases among Varied Pedigree Structures.

Older age is associated with decline in many physiological functions that eventually lead to increased susceptibility to diseases. The rate of aging varies among individuals and may be influenced by genes. This dissertation has three aims: 1) define a measure of aging using physiologic traits and determine its heritability among various pedigree structures, 2) investigate genetic associations with the age trait using genome-wide association study analyses, and 3) focus on decline in kidney function by examining its association with known kidney loci and clinical risk factors within the SardiNIA Study on Aging. Using data from five genetic cohorts (30,000+ individuals) with varying pedigree structure (SardiNIA Study on Aging – large pedigrees, Framingham Heart Study offspring – small pedigrees, Atherosclerotic Risk in Communities Study – unrelated, and two twins studies: Twingene and TwinsUK), two aging traits were developed. Both traits employ three physiologic health measures (kidney function, systolic blood pressure, and waist circumference) to estimate an individual’s biologic age and contrast it with actual age. Linear mixed modeling was employed to estimate a predicted age, while Cox models were used to estimate a risk age equivalent to the age of the census population with the same mortality risk. Using Merlin software (Abecasis, 2002), both age traits were found to be heritable in all cohorts with h2 estimates of 0.25 to 0.68, depending on pedigree structure. Meta-analysis revealed a genome-wide significant association (p < 5 x 10-8) within the LRP1B gene on chromosome 2. LRP1B produces low density lipoprotein receptor-related protein 1B and has been previously associated with tumor suppression, metabolic traits, and successful aging. Association analyses were also conducted using a genetic risk score for CKD, adjusting for clinical factors, with CKD prevalence and change in kidney function. One additional allele in the genetic risk score for CKD was significantly associated with CKD prevalence (OR=1.07, p=0.001), decline in eGFR (β=-0.23, p=0.004), and eGFR decline > 1 SD (OR=1.05, p=0.04). These findings further our understanding of the genetics of aging and the CKD risk score results suggest a possible clinical utility. Putting the findings into clinical use should be evaluated.PHDEpidemiological ScienceUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/97920/1/jennb_1.pd

Cooperative Restoration Programs in Critical Habitats in the Upper South Carolina Coastal Region

2008 S.C. Water Resources Conference - Addressing Water Challenges Facing the State and Regio

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain \u3e99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. Our findings highlight the value of using multiple traits to define complex phenotypes for discovery, which are not captured by single-trait analyses, and may shed light onto new pathways

Regional Initiatives in Support of Surveillance in East Africa: The East Africa Integrated Disease Surveillance Network (EAIDSNet) Experience.

The East African Integrated Disease Surveillance Network (EAIDSNet) was formed in response to a growing frequency of cross-border malaria outbreaks in the 1990s and a growing recognition that fragmented disease interventions, coupled with weak laboratory capacity, were making it difficult to respond in a timely manner to the outbreaks of malaria and other infectious diseases. The East Africa Community (EAC) partner states, with financial support from the Rockefeller Foundation, established EAIDSNet in 2000 to develop and strengthen the communication channels necessary for integrated cross-border disease surveillance and control efforts. The objective of this paper is to review the regional EAIDSNet initiative and highlight achievements and challenges in its implementation. Major accomplishments of EAIDSNet include influencing the establishment of a Department of Health within the EAC Secretariat to support a regional health agenda; successfully completing a regional field simulation exercise in pandemic influenza preparedness; and piloting a web-based portal for linking animal and human health disease surveillance. The strategic direction of EAIDSNet was shaped, in part, by lessons learned following a visit to the more established Mekong Basin Disease Surveillance (MBDS) regional network. Looking to the future, EAIDSNet is collaborating with the East, Central and Southern Africa Health Community (ECSA-HC), EAC partner states, and the World Health Organization to implement the World Bank-funded East Africa Public Health Laboratory Networking Project (EAPHLNP). The network has also begun lobbying East African countries for funding to support EAIDSNet activities