Twenty Years of Disturbance and Change in Fagatele Bay National Marine Sanctuary, American Samoa

Fagatele Bay National Marine Sanctuary contains a moderately diverse coral reef community (150 coral species, 259 fish species) that is protected from most human activities. The coral community was devastated by a crown-of-thorns starfish invasion in 1979 and has recently been affected by two major hurricanes (1990 and 1991) and a period of unusually high water temperature (1994). Long-term monitoring of the sanctuary allows for description of the effects of these disturbances in the absence of anthropogenic processes. The crown-of-thorns damaged deeper portions of the coral communities most severely, whereas the hurricanes and warm water affected shallower portions to a greater degree. Soon after these disturbances, corals started recruiting abundantly and the reefs began to recover. This is in contrast to some other areas in American Samoa, where chronic anthropogenic effects seem to have inhibited coral recruitment and reef recovery. Fish communities were affected by the habitat degradation associated with the crown-of-thorns outbreak, but have remained relatively unchanged ever since

Geometric Aspects of D-branes and T-duality

We explore the differential geometry of T-duality and D-branes. Because D-branes and RR-fields are properly described via K-theory, we discuss the (differential) K-theoretic generalization of T-duality and its application to the coupling of D-branes to RR-fields. This leads to a puzzle involving the transformation of the A-roof genera in the coupling.Comment: 26 pages, JHEP format, uses dcpic.sty; v2: references added, v3: minor change

JAK2V617F promotes replication fork stalling with disease-restricted impairment of the intra-S checkpoint response

Cancers result from the accumulation of genetic lesions, but the cellular consequences of driver mutations remain unclear, especially during the earliest stages of malignancy. The V617F mutation in the JAK2 non-receptor tyrosine kinase (JAK2V617F) is present as an early somatic event in most patients with myeloproliferative neoplasms (MPNs), and the study of these chronic myeloid malignancies provides an experimentally tractable approach to understanding early tumorigenesis. Introduction of exogenous JAK2V617F impairs replication fork progression and is associated with activation of the intra-S checkpoint, with both effects mediated by phosphatidylinositide 3-kinase (PI3K) signaling. Analysis of clonally derived JAK2V617F-positive erythroblasts from MPN patients also demonstrated impaired replication fork progression accompanied by increased levels of replication protein A (RPA)-containing foci. However, the associated intra-S checkpoint response was impaired in erythroblasts from polycythemia vera (PV) patients, but not in those from essential thrombocythemia (ET) patients. Moreover, inhibition of p53 in PV erythroblasts resulted in more gamma-H2Ax (γ-H2Ax)–marked double-stranded breaks compared with in like-treated ET erythroblasts, suggesting the defective intra-S checkpoint function seen in PV increases DNA damage in the context of attenuated p53 signaling. These results demonstrate oncogene-induced impairment of replication fork progression in primary cells from MPN patients, reveal unexpected disease-restricted differences in activation of the intra-S checkpoint, and have potential implications for the clonal evolution of malignancies

Constraining the primordial spectrum of metric perturbations from gravitino and moduli production

We consider the production of gravitinos and moduli fields from quantum vacuum fluctuations induced by the presence of scalar metric perturbations at the end of inflation. We obtain the corresponding occupation numbers, up to first order in perturbation theory, in terms of the power spectrum of the metric perturbations. We compute the limits imposed by nucleosynthesis on the spectral index $n_s$ for different models with constant $n_s$. The results show that, in certain cases, such limits can be as strong as $n_s<1.12$, which is more stringent than those coming from primordial black hole production.Comment: 16 pages, LaTeX, 5 figures. Corrected figures, new references included. Final version to appear in Phys. Rev.

A cross sectional study of the prevalence and associated risks for bursitis in 6250 weaner, grower and finisher pigs from 103 British pig farms

A cross-sectional study of 93 farms in England was carried out to estimate the prevalence and associated risk factors for bursitis. A total of 6250 pigs aged 6–22 weeks were examined for presence and severity of bursitis. Details of pen construction, pen quality and farm management were recorded including floor type, presence of bedding, condition of the floor and floor materials. The prevalence of bursitis was 41.2% and increased with each week of age (OR 1.1). Two-level logistic regression models were developed with the outcome as the proportion of pigs affected with bursitis in a pen. Pigs kept on soil floors with straw bedding were used as the reference level. In comparison with these soil floors, bursitis increased on concrete floors where the bedding was deep throughout (OR 4.6), deep in part (OR 3.7), and sparse throughout (OR 9.0), part slatted floors (OR 8.0), and fully slatted floors (OR 18.8). Slip or skid marks in the dunging area (OR 1.5), pigs observed slipping during the examination of the pen (OR 1.3) and wet floors (OR 3.6) were also associated with an increased risk of bursitis. The results indicate that bursitis is a common condition of growing pigs and that the associated risk factors for bursitis were a lack of bedding in the lying area, presence of voids and pen conditions which increased the likelihood of injury

STAT1 activation in association with JAK2 exon 12 mutations

La inclusión de la perspectiva de género en la actividad jurisdiccional es una demanda sostenida de los colectivos feministas y de mujeres, dado que las sentencias tienen un poder performativo y envían un mensaje a la sociedad: “[…] tienen un poder individual y colectivo que impactan en la vida de las personas y conforman la identidad del poder judicial como un actor imprescindible en la construcción de un Estado democrático de derecho” (Suprema Corte de Justicia de la Nación, 2013:7). La incorporación de la perspectiva de género viene a garantizar la igualdad de posiciones (Kessler, 2014) entre mujeres y varones como una meta, trascendiendo la mera igualdad de oportunidades que hasta el presente se ha demostrado insuficiente para que las mujeres consigamos una ciudadanía plena. Al momento de incorporar la perspectiva de género en las sentencias, quienes juzgan deben tener presente en primer lugar, el impacto diferenciado de las normas en base al sexo de las personas. En segundo lugar, la interpretación y aplicación de las leyes en relación con (y en base a) estereotipos de género. Si, por ejemplo, quienes imparten justicia no tienen presentes los estereotipos de género vigentes detrás de las violaciones a los derechos humanos de las mujeres, si no los detectan ni cuestionan, entonces los reproducen. Tal como sostiene Scott (1996) el género es una categoría imprescindible para el análisis social. En tercer lugar, al momento del juzgamiento, se deben tener en cuenta las exclusiones legitimadas por la ley por pensar el mundo en términos binarios y androcéntricos; en cuarto lugar, la distribución no equitativa de recursos y poder que opera entre varones y mujeres en el marco de una organización social patriarcal, y, por último, el trato diferenciado por género legitimado por las propias leyes.Eje 3: Tramas violentas y espacios de exclusión.Instituto de Cultura Jurídic

Resonant production of fermions in an axial background

We consider the resonant production of fermions from an oscillating axial background. The classical evolution of the axial field is given by that of a massive pseudovector field, as suggested by the renormalizability of the theory. We look upon both the massive and the massless fermion production from a perturbative point of view. We obtain the corresponding spectrum and angular distributions for the different spins or helicities in the particular case of a spatial-like axial field. We also extend our study to the non-perturbative regime in the massless case and compare the results with the perturbative ones.Comment: 16 pages, LaTeX, 12 figures; new comments and references added, version to appear in Phys. Rev.

New Coherent String States and Minimal Uncertainty in WZWN Models

We study the properties of {\bf exact} (all level $k$) quantum coherent states in the context of string theory on a group manifold (WZWN models). Coherent states of WZWN models may help to solve the unitarity problem: Having positive norm, they consistently describe the very massive string states (otherwise excluded by the spin-level condition). These states can be constructed by (at least) two alternative procedures: (i) as the exponential of the creation operator on the ground state, and (ii) as eigenstates of the annhilation operator. In the $k\to\infty$ limit, all the known properties of ordinary coherent states are recovered. States (i) and (ii) (which are equivalent in the context of ordinary quantum mechanics and string theory in flat spacetime) are not equivalent in the context of WZWN models. The set (i) was constructed by these authors in a previous article. In this paper we provide the construction of states (ii), we compare the two sets and discuss their properties. We analyze the uncertainty relation, and show that states (ii) satisfy automatically the {\it minimal uncertainty} condition for any $k$; they are thus {\it quasiclassical}, in some sense more classical than states (i) which only satisfy it in the $k\to\infty$ limit. Modification to the Heisenberg relation is given by $2 {\cal H}/k$, where ${\cal H}$ is connected to the string energy.Comment: More discussion on relation to previous work. More references added. 14 pages, Latex, no figure

On the inflationary solutions in higher-derivative gravity with dilaton field

We discuss the existence of de Sitter inflationary solutions for the string-inspired fourth-derivative gravity theories with dilaton field. We consider a space-time of arbitrary dimension D and an arbitrary parametrization of the target space metric. The specific features of the theory in dimension D=4 and those of the special ghost-free parametrization of the metric are found. We also consider similar string-inspired theories with torsion and construct an inflationary solution with torsion and dilaton for D=4. The stability of the inflationary solutions is also investigated.Comment: 13 pages, LaTeX, no figure

String Form Factors

We compute the cross section for scattering of light string probes by randomly excited closed strings. For high energy probes, the cross section factorizes and can be used to define effective form factors for the excited targets. These form factors are well defined without the need for infinite subtractions and contain information about the shape and size of typical strings. For highly excited strings the elastic form factor can be written in terms of the `plasma dispersion function', which describes charge screening in high temperature plasmas.Comment: 18 pages, 3 figures. Typos corrected, 1 footnote (in Section 4) and 1 reference adde