562 research outputs found
The Relation of the Christian To Civil Government and War: 2nd Edition
https://digitalcommons.acu.edu/crs_books/1244/thumbnail.jp
The Relation of the Christian To Civil Government and War
https://digitalcommons.acu.edu/crs_books/1561/thumbnail.jp
Regulatory Considerations in the Design and Manufacturing of Implantable 3DâPrinted Medical Devices
Threeâdimensional (3D) printing, or additive manufacturing, technology has rapidly penetrated the medical device industry over the past several years, and innovative groups have harnessed it to create devices with unique composition, structure, and customizability. These distinctive capabilities afforded by 3D printing have introduced new regulatory challenges. The customizability of 3Dâprinted devices introduces new complexities when drafting a design control model for FDA consideration of market approval. The customizability and unique build processes of 3Dâprinted medical devices pose unique challenges in meeting regulatory standards related to the manufacturing quality assurance. Consistent material powder properties and optimal printing parameters such as build orientation and laser power must be addressed and communicated to the FDA to ensure a quality build. Postprinting considerations unique to 3Dâprinted devices, such as cleaning, finishing and sterilization are also discussed. In this manuscript we illustrate how such regulatory hurdles can be navigated by discussing our experience with our group's 3Dâprinted bioresorbable implantable device.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/115990/1/cts12315.pd
Biomechanical evaluation of human and porcine Auricular cartilage
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/112214/1/lary25040.pd
Detection of a glitch in the pulsar J1709-4429
We report the detection of a glitch event in the pulsar J17094429 (also
known as B170644) during regular monitoring observations with the Molonglo
Observatory Synthesis Telescope (UTMOST). The glitch was found during timing
operations, in which we regularly observe over 400 pulsars with up to daily
cadence, while commensally searching for Rotating Radio Transients, pulsars,
and FRBs. With a fractional size of ,
the glitch reported here is by far the smallest known for this pulsar,
attesting to the efficacy of glitch searches with high cadence using UTMOST.Comment: 3 pages, 1 figur
Non-Thermal X-ray Emission from the Northwestern Rim of the Galactic Supernova Remnant G266.2-1.2 (RX J0852.0-4622)
We present a detailed spatially-resolved spectroscopic analysis of two X-ray
observations (with a total integration time of 73280 seconds) made of the
luminous northwestern rim complex of the Galactic supernova remnant (SNR)
G266.2-1.2 (RX J0852.0-4622) with the Chandra X-ray Observatory. G266.2-1.2 is
a member of a class of Galactic SNRs which feature X-ray spectra dominated by
non-thermal emission: in the cases of these SNRs, the emission is believed to
have a synchrotron origin and studies of the X-ray spectra of these SNRs can
lend insights into how SNRs accelerate cosmic-ray particles. The Chandra
observations have clearly revealed fine structure in this rim complex and the
spectra of these features are dominated by non-thermal emission. We have
measured the length scales of the upstream structures at eight positions along
the rim and derive lengths of 0.02-0.08 pc (assuming a distance of 750 pc to
G266.2-1.2). We have also extracted spectra from seven regions in the rim
complex and fit these spectra with such models as a simple power law as well as
the synchrotron models SRCUT and SRESC. We have constrained our fits to the
latter two models using estimates for the flux densities of these filaments at
1 GHz as determined from radio observations made with the Australia Telescope
Compact Array (ATCA). Statistically-acceptable fits to all seven regions are
derived using each model: differences in the fit parameters (such as photon
index and cutoff frequency) are seen in the different regions, which may
indicate variations in shock conditions and the maximum energies of the
cosmic-ray electrons accelerated at each region. Finally, we estimate the
maximum energy of cosmic-ray electrons accelerated along this rim complex to be
approximately 40 TeV. We include a summary of estimated maximum energies for
both Galactic SNRs as well as SNRs located in the Large Magellanic Cloud.Comment: 56 Pages, 11 Figures, Accepted for publication in the Astrophysical
Journa
Does High BMI Influence Hospital Charges in Children Undergoing Adenotonsillectomy?
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/93757/1/oby.2008.234.pd
PLZF-expressing CD4 T cells show the characteristics of terminally differentiated effector memory CD4 T cells in humans
In humans, promyelocytic leukaemia zinc
finger (PLZF)+CD161+CD4 T cells develop
in the fetal thymus [1] but these cells were
not detectable in thymi obtained from children
(11 days to 5.5 years) (Fig. 1A).
However, we found PLZF+CD4 T cells
within CD45RA+RO+CD4 T cells from tonsils
and spleens but rarely in blood (Fig. 1B,
left panel and 1C; Supporting Information
Fig. 1A and B). PLZF expression was
also confirmed by mRNA analysis in these
cells from tonsils (Fig. 1B, right panel).
CD8 T cells had a very low frequency
of CD45RA+RO+ cells compared to CD4
T cells and these cells did not express
PLZF (Fig. 1B). We also validated that
CD45RA+RO+CD4 T cells are not mucosalassociated
invariant T cells [2] (data not
shown). PLZF-expressing NKT cells were
excluded from all our analyses by CD1d-
Tetramer staining (Supporting Information
Fig. 2
âSons of athelings given to the earthâ: Infant Mortality within Anglo-Saxon Mortuary Geography
FOR 20 OR MORE YEARS early Anglo-Saxon archaeologists have believed children are underrepresented in the cemetery evidence. They conclude that excavation misses small bones, that previous attitudes to reporting overlook the very young, or that infants and children were buried elsewhere. This is all well and good, but we must be careful of oversimplifying compound social and cultural responses to childhood and infant mortality. Previous approaches have offered methodological quandaries in the face of this under-representation. However, proportionally more infants were placed in large cemeteries and sometimes in specific zones. This trend is statistically significant and is therefore unlikely to result entirely from preservation or excavation problems. Early medieval cemeteries were part of regional mortuary geographies and provided places to stage events that promoted social cohesion across kinship systems extending over tribal territories. This paper argues that patterns in early Anglo-Saxon infant burial were the result of female mobility. Many women probably travelled locally to marry in a union which reinforced existing social networks. For an expectant mother, however, the safest place to give birth was with experience women in her maternal home. Infant identities were affected by personal and legal association with their motherâs parental kindred, so when an infant died in childbirth or months and years later, it was their motherâs identity which dictated burial location. As a result, cemeteries central to tribal identities became places to bury the sons and daughters of a regional tribal aristocracy
The Gray Needle: Large Grains in the HD 15115 Debris Disk from LBT/PISCES/Ks and LBTI/LMIRcam/L' Adaptive Optics Imaging
We present diffraction-limited \ks band and \lprime adaptive optics images of
the edge-on debris disk around the nearby F2 star HD 15115, obtained with a
single 8.4 m primary mirror at the Large Binocular Telescope. At \ks band the
disk is detected at signal-to-noise per resolution element (SNRE) \about 3-8
from \about 1-2\fasec 5 (45-113 AU) on the western side, and from \about
1.2-2\fasec 1 (63-90 AU) on the east. At \lprime the disk is detected at SNRE
\about 2.5 from \about 1-1\fasec 45 (45-90 AU) on both sides, implying more
symmetric disk structure at 3.8 \microns . At both wavelengths the disk has a
bow-like shape and is offset from the star to the north by a few AU. A surface
brightness asymmetry exists between the two sides of the disk at \ks band, but
not at \lprime . The surface brightness at \ks band declines inside 1\asec
(\about 45 AU), which may be indicative of a gap in the disk near 1\asec. The
\ks - \lprime disk color, after removal of the stellar color, is mostly grey
for both sides of the disk. This suggests that scattered light is coming from
large dust grains, with 3-10 \microns -sized grains on the east side and 1-10
\microns dust grains on the west. This may suggest that the west side is
composed of smaller dust grains than the east side, which would support the
interpretation that the disk is being dynamically affected by interactions with
the local interstellar medium.Comment: Apj-accepted March 27 2012; minor correction
- âŠ