3,902 research outputs found
Phosphorescence and donor-acceptor pair recombination in laboratory-grown diamonds
Intense "blue-green" phosphorescence is commonly observed in near colourless
lab-grown high-pressure high-temperature (HPHT) diamonds following optical
excitation at or above the indirect bandgap. We have employed a holistic
combination of optically-excited time-resolved techniques (in addition to
standard spectroscopic characterisation techniques) to study the physics of
this long-lived phosphorescence and understand luminescence-related charge
transfer processes.
It is shown that the properties of the broad "blue-green" luminescence and
phosphorescence band can be fully explained by emission from neutral
substitutional nitrogen-boron donor-acceptor pairs
(...) , once the configurational
change between charge states is considered, and both tunneling between defects
and thermal ionization of donors and acceptors is considered. Significant
concentrations of metastable , are identified after
optical excitation at or above the indirect bandgap. is
much shallower (0.2 eV) than previously thought and plays a key role in
resetting the ... donor-acceptor
pairs.Comment: 15 pages, 13 figure
All-optical hyperpolarization of electron and nuclear spins in diamond
Low thermal polarization of nuclear spins is a primary sensitivity limitation
for nuclear magnetic resonance. Here we demonstrate optically pumped
(microwave-free) nuclear spin polarization of and
in -doped diamond.
polarization enhancements up to above thermal equilibrium are observed
in the paramagnetic system . Nuclear spin polarization is
shown to diffuse to bulk with NMR enhancements of at
room temperature and at , enabling a route to
microwave-free high-sensitivity NMR study of biological samples in ambient
conditions.Comment: 5 pages, 5 figure
Knowledge of Driving Vehicle Licensing Agency guidelines among NHS doctors:A multicentre observational study
Objectives: Over half of the UK population holds a driver's licence. The DVLA have produced guidelines to ensure drivers with medical conditions drive safely. Doctors should ensure that patients are given appropriate information and advice if they have a medical condition affecting their driving. We sought to evaluate doctors' knowledge of DVLA guidelines. Design: A 25-point questionnaire was designed from DVLA guidelines (‘The DVLA Questionnaire’). Five questions were included for each of neurology, cardiology, drug and alcohol abuse, visual, and respiratory disorders. Setting: Ealing Hospital, Northwick Park Hospital, Watford General Hospital, Norfolk and Norwich University Hospital and Leeds Teaching Hospitals Trust. Participants: 140 UK doctors. Main outcome measures: Questionnaire scores assessing knowledge of DVLA guidelines in five specialty areas. Results: The median overall questionnaire score was 28%, interquartile range 20–36% and range 0–100% [Watford 28%, Leeds 30%, Norfolk and Norwich 36%, Ealing 30%, Northwick Park 28%]. There were no significant differences between the scores for each centre (p = 0.1332), Mean scores for specialty areas were: neurology 33.1%, standard deviation 22.1; cardiology 35.6%, standard deviation 26.9; drug and alcohol abuse 30.6%, standard deviation 23.8; visual disorders 33.9%, standard deviation 23.5 and respiratory disorders 20.3%, standard deviation 24.8; overall score 30.7%. There was no significant difference between the scores of the specialty areas (p = 0.4060). Conclusions: Knowledge of DVLA guidelines in our cohort was low. There is a need for increased awareness among hospital doctors through focused education on driving restrictions for common medical conditions. Improving physician knowledge in this area may help optimise patient safety
The norovirus NS3 protein is a dynamic lipid- and microtubule-associated protein involved in viral RNA replication
Norovirus (NoV) infections are a significant health burden to society, yet the lack of reliable tissue culture systems has hampered the development of appropriate antiviral therapies. Here we show that the NoV NS3 protein, derived from murine NoV (MNV), is intimately associated with the MNV replication complex and the viral replication intermediate double-stranded RNA (dsRNA). We observed that when expressed individually, MNV NS3 and NS3 encoded by human Norwalk virus (NV) induced the formation of distinct vesicle-like structures that did not colocalize with any particular protein markers to cellular organelles but localized to cellular membranes, in particular those with a high cholesterol content. Both proteins also showed some degree of colocalization with the cytoskeleton marker β-tubulin. Although the distribution of MNV and NV NS3s were similar, NV NS3 displayed a higher level of colocalization with the Golgi apparatus and the endoplasmic reticulum (ER). However, we observed that although both proteins colocalized in membranes counterstained with filipin, an indicator of cholesterol content, MNV NS3 displayed a greater association with flotillin and stomatin, proteins known to associate with sphingolipid- and cholesterol-rich microdomains. Utilizing time-lapse epifluorescence microscopy, we observed that the membrane-derived vesicular structures induced by MNV NS3 were highly motile and dynamic in nature, and their movement was dependent on intact microtubules. These results begin to interrogate the functions of NoV proteins during virus replication and highlight the conserved properties of the NoV NS3 proteins among the seven Norovirus genogroups
Trends in multimorbidity, complex multimorbidity and multiple functional limitations in the ageing population of England, 2002–2015
This is the final version. Available from SAGE via the DOI in this record.This study aimed to estimate the prevalence of three measures of multimorbidity among people aged 50 years or older in England. Beside the basic measure of two or more diseases within a person, we added a measure of three or more affected body systems (complex multimorbidity) and a measure of 10 or more functional limitations. We found that the three health outcomes became more prevalent between 2002 and 2015. They were more common among females than males and were becoming more common among younger age groups. While in 2002, the prevalence of basic multimorbidity overcame 50% from the 70–74 age group upwards, in 2015 it crossed the same threshold in the 65–69 age group. The distribution of multimorbidity and multiple functional limitations were stratified by the amount of household wealth. Multiple functional limitations reflected the largest differences between the most and the least affluent groups (5.9-fold in 2014/2015), followed by the measure of complex multimorbidity (2.8-fold in 2014/2015) and basic multimorbidity (1.9-fold) in 2014/2015.While age acted as a levelling factor for the wealth differences in basic multimorbidity, it had no such effect on the two other outcomes. Our study observed social polarization among multimorbid ageing population in England where complex multimorbidity and multiple functional limitations increase faster and reflect stronger inequality than basic multimorbidity
Observations of Mass Loss from the Transiting Exoplanet HD 209458b
Using the new Cosmic Origins Spectrograph (COS) on the {\it Hubble Space
Telescope (HST)}, we obtained moderate-resolution, high signal/noise
ultraviolet spectra of HD 209458 and its exoplanet HD 209458b during transit,
both orbital quadratures, and secondary eclipse. We compare transit spectra
with spectra obtained at non-transit phases to identify spectral features due
to the exoplanet's expanding atmosphere. We find that the mean flux decreased
by % for the C II 1334.5323\AA\ and 1335.6854\AA\ lines and by
% for the Si III 1206.500\AA\ line during transit compared to
non-transit times in the velocity interval --50 to +50 km s. Comparison
of the C II and Si III line depths and transit/non-transit line ratios shows
deeper absorption features near --10 and +15 km s and less certain
features near --40 and +30--70 km s, but future observations are needed
to verify this first detection of velocity structure in the expanding
atmosphere of an exoplanet. Our results for the C II lines and the
non-detection of Si IV 1394.76\AA\ absorption are in agreement with
\citet{Vidal-Madjar2004}, but we find absorption during transit in the Si III
line contrary to the earlier result. The % obscuration of the star
during transit is far larger than the 1.5% obscuration by the exoplanet's disk.
Absorption during transit at velocities between --50 and +50 km s in the
C II and Si III lines requires high-velocity ion absorbers, but models that
assume that the absorbers are high-temperature thermal ions are inconsistent
with the COS spectra. Assuming hydrodynamic model values for the gas
temperature and outflow velocity at the limb of the outflow as seen in the C II
lines, we find mass-loss rates in the range (8--40) g s.Comment: 25 pages, 4 figures, Astrophysical Journal in pres
Deep three-dimensional solid-state qubit arrays with long-lived spin coherence
Nitrogen-vacancy centers (NVCs) in diamond show promise for quantum computing, communication, and sensing. However, the best current method for entangling two NVCs requires that each one is in a separate cryostat, which is not scalable. We show that single NVCs can be laser written 6–15-µm deep inside of a diamond with spin coherence times that are an order of magnitude longer than previous laser-written NVCs and at least as long as naturally occurring NVCs. This depth is suitable for integration with solid immersion lenses or optical cavities and we present depth-dependent T2 measurements. 200 000 of these NVCs would fit into one diamond
Searching for Far-Ultraviolet Auroral/Dayglow Emission from HD209458b
We present recent observations from the HST-Cosmic Origins Spectrograph aimed
at characterizing the auroral emission from the extrasolar planet HD209458b. We
obtained medium-resolution (R~18-20,000) far-ultraviolet (1150-1700A) spectra
at both the Phase 0.25 and Phase 0.75 quadrature positions as well as a stellar
baseline measurement at secondary eclipse. This analysis includes a catalog of
stellar emission lines and a star-subtracted spectrum of the planet. We present
an emission model for planetary H2 emission, and compare this model to the
planetary spectrum. No unambiguously identifiable atomic or molecular features
are detected, and upper limits are presented for auroral/dayglow line
strengths. An orbital velocity cross-correlation analysis finds a statistically
significant (3.8 sigma) feature at +15 (+/- 20) km/s in the rest frame of the
planet, at 1582 A. This feature is consistent with emission from H2 B-X (2-9)
P(4) (lambda_{rest} = 1581.11 A), however the physical mechanism required to
excite this transition is unclear. We compare limits on relative line strengths
seen in the exoplanet spectrum with models of ultraviolet fluorescence to
constrain the atmospheric column density of neutral hydrogen between the star
and the planetary surface. These results support models of short period
extrasolar giant planets with weak magnetic fields and extended atomic
atmospheres.Comment: Accepted to ApJ. 12 pages, 5 figures, 4 table
Laser writing of individual atomic defects in a crystal with near-unity yield
Atomic defects in wide band gap materials show great promise for development
of a new generation of quantum information technologies, but have been hampered
by the inability to produce and engineer the defects in a controlled way. The
nitrogen-vacancy (NV) color center in diamond is one of the foremost
candidates, with single defects allowing optical addressing of electron spin
and nuclear spin degrees of freedom with potential for applications in advanced
sensing and computing. Here we demonstrate a method for the deterministic
writing of individual NV centers at selected locations with high positioning
accuracy using laser processing with online fluorescence feedback. This method
provides a new tool for the fabrication of engineered materials and devices for
quantum technologies and offers insight into the diffusion dynamics of point
defects in solids.Comment: 16 pages, 8 figure
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