Clinical pharmacology becomes a specialty in South Africa

South Africa recently became the first African country where clinical pharmacology has been approved as a specialty. This article outlines the need for clinical pharmacologists, their role in advancing public health, the potential benefits to the country, and recommendations for ensuring a healthy future for the discipline

Reactivity of (1-methoxycarbonylpentadienyl)iron(1+) cations with hydride, methyl, and nitrogen nucleophiles

The reaction of tricarbonyl and (dicarbonyl)triphenylphosphine (1-methoxycarbonyl-pentadientyl)iron(1+) cations 7 and 8 with methyl lithium, NaBH3CN, or potassium phthalimide affords (pentenediyl)iron complexes 9a-c and 11a-b, while reaction with dimethylcuprate, gave (E,Z-diene)iron complexes 10 and 12. Oxidatively induced-reductive elimination of 9a-c gave vinylcyclopropanecarboxylates 17a-c. The optically active vinylcyclopropane (+)-17a, prepared from (1S)-7, undergoes olefin cross-metathesis with excess (+)-18 to yield (+)-19, a C9C16 synthon for the antifungal agent ambruticin. Alternatively reaction of 7 with methanesulfonamide or trimethylsilylazide gave (E,E-diene)iron complexes 14d and e. Huisgen [3 + 2] cyclization of the (azidodienyl)iron complex 14e with alkynes afforded triazoles 25a-e

Estudio del campo magnético de un solenoide con experimento remoto y simulación

En este trabajo se describe una propuesta de ense&ntilde;anza basada en el concepto de aprendizaje colaborativo, que integra el uso de un experimento remoto y una simulaci&oacute;n, con los cuales se mide el campo magn&eacute;tico de un solenoide, y se lo calcula mediante la ley de Biot y Savart. El alumno puede comparar los resultados obtenidos a partir de estas herramientas cognitivas, con los que predice la ley de Ampere, y de esa forma comprender con mayor profundidad la funci&oacute;n que cumplen distintos modelos f&iacute;sicos que se usan para representar a un mismo sistema.El experimento remoto fue probado en dos talleres de capacitaci&oacute;n docente, y el dise&ntilde;o did&aacute;ctico fue validado con un grupo de alumnos que trabaj&oacute; con el mismo en forma voluntaria. La pro-puesta se pone a consideraci&oacute;n de otros colegas con la finalidad que la utilicen con sus alumnos, considerando a su vez que la misma puede ser perfeccionada en base a distintos aportes.</div

Recent Applications of Acyclic (Diene)iron Complexes and (Dienyl)iron Cations in Organic Synthesis

Complexation of (tricarbonyl)iron to an acyclic diene serves to protect the ligand against oxidation, reduction, and cycloaddition reactions, whereas the steric bulk of this adjunct serves to direct the approaches of reagents to unsaturated groups attached to the diene onto the face opposite to iron. Furthermore, the Fe(CO)3 moiety can serve to stabilize carbocation centers adjacent to the diene (i.e. pentadienyl-iron cations). Recent applications of these reactivities to the synthesis of polyene-, cyclopropane-, cycloheptadiene-, and cyclohexenone-containing natural products or analogues are presented