9 research outputs found
Clinical characteristics and evolution of syphilis in 24 HIV+ individuals in Rio de Janeiro, Brazil CaracterĂsticas clĂnicas e evolutivas da sĂfilis em 24 indivĂduos HIV+ no Rio de Janeiro, Brasil
A total of 24 patients with syphilis and HIV infection were treated from January 1997 to March 2003 at the Infectious Dermatology Outpatient Clinic of the Evandro Chagas Clinical Research Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. The caseload consisted of 20 males (83.3%) and four females (16.7%), with a mean age of 38.04 years and mean T CD4+ count of 389.5 cells/mL. Syphilis was diagnosed as secondary in 16 (62.5%) patients, late latent in eight (33.3%), and tertiary in one (4.2%). Manifestations of secondary syphilis were palmar and plantar erythematopapulous cutaneous lesions in nine (37.5%), papulous exanthema in four (16.7%), patchy alopecia in 3 (12.5%) and osteochondritis in one patient (4.2%). Tertiary syphilis was characterized by verrucous lesions. Neurosyphilis was diagnosed in four patients (16.7%), with headache as the only manifestation in two patients. Drugs used in treatment included benzathine penicillin, ceftriaxone, erythromycin, and crystalline penicillin. Cure was achieved in 18 patients (75%). Five patients (20.8%) were retreated, three of whom presented a history of re-exposure. This study confirms the importance of establishing the diagnosis of neurosyphilis in patients with HIV infection, in addition to performing follow-up on treatment for syphilis.<br>Foram tratados 24 indivĂduos com sĂfilis e infecção pelo HIV, de Março de 1997 a Janeiro de 2003, no ambulatĂłrio de Dermatologia Infecciosa do Instituto de Pesquisa ClĂnica Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil. Foram 20 homens (83,3%) e quatro mulheres (16,7%) com idade mĂ©dia de 38,04 anos e contagem mĂ©dia de linfĂłcitos T CD4 de 389,5 cĂ©ls/mmÂł. A sĂfilis foi classificada como secundária em 16 pacientes (62,5%), latente tardia em oito (33,3%) e terciária em uma paciente (4,2%). As manifestações de sĂfilis secundária foram de lesões cutâneas eritematopapulosas em regiões palmar e plantar em nove (37,5%), exantema papuloso em quatro (16,7%), alopecia em clareira em trĂŞs (12,5%) e osteocondrite em um paciente (4,2%). A sĂfilis terciária apresentou-se como lesĂŁo verrucosa. Cinco pacientes (20,8%) apresentavam neurossĂfilis, sendo a cefalĂ©ia a Ăşnica manifestação presente em dois pacientes. As drogas utilizadas foram penicilina benzatina, ceftriaxone, eritromicina e penicilina. A cura ocorreu em 18 pacientes (75%). Seis pacientes (25%) foram retratados, sendo que trĂŞs apresentavam histĂłria de re-exposição. Este estudo confirmou a importância de se estabelecer o diagnĂłstico de neurossĂfilis em pacientes com infecção pelo HIV, assim como de se realizar seguimento clĂnico e laboratorial apĂłs o tratamento da sĂfilis
Dimensions and alignments in European Union politics: cognitive constraints and partisan responses
As the European Union (EU) has evolved, the study agenda has shifted from 'European integration' to 'EU politics'. Missing from this new agenda, however, is an understanding of the 'cognitive constraints' on actors and how actors respond, i.e. the shape of the EU 'political space' and the location of social groups and competition between actors within this space. The article develops a theoretical framework for understanding the shape of the EU political space (the interaction between an Integration–Independence and Left–Right dimension and the location of class and sectoral groups within this map), and tests this framework on the policy positions of the Socialist, Christian Democrat and Liberal party leaders between 1976 and 1994 (using the techniques of the ECPR Party Manifestos Group Project). The research finds that the two dimensions were salient across the whole period, explains why the party families converged on pro–European positions by the 1990s and discovers the emergence of a triangular 'core' of EU politics
A comprehensive model of predictors of quality of life in older adults with schizophrenia: results from the CSA study
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