FABP-2 and PPAR-γ Haplotype as Risk Factors for Dyslipidemia in a Type 2 Diabetes Mellitus Population of Santa Rosa del Conlara, San Luis, Argentina

Introduction: Type 2 Diabetes Mellitus (T2DM) is a complex disorder caused by the interaction between genetic predisposition and environmental factors. Genetics plays an important role on lipid homeostasis. Many genes are involved in the lipid metabolism, such as FABP-2 and PPAR-γ. Aim: To evaluate the association between specific SNPs and haplotypes of the FABP-2 and PPAR-γ genes with T2DM and lipid profile in an Argentinean population. Methods: The FABP-2 (rs1799883) and PPAR-γ (rs1801282) polymorphisms were genotyped and analyzed in association with lipid profile and T2DM, separately and also combined in haplotypes. Results: The frequency of the rare Thr54 allele of the FABP-2 polymorphism in control (0.33) was not different from the frequency in T2DM (0.27), whereas the frequency of the rare Ala12 allele of the PPAR-γ polymorphism in control was different from the frequency in T2DM (0.26 and 0.14, respectively; p = 0.0031). Frequencies of haplotypes for these two single-nucleotide polymorphisms differed significantly in control and T2DM. Haplotype association analysis showed the associations between ThrPro haplotype and TG levels (OR = 2.520; 95% CI = 1.139 - 5.575; p = 0.027) and between ThrPro haplotype and TC and LDL-c levels when compared to AlaPro haplotype (difference = 0.175, 95% CI = 0068 - 0.499, p < 0.0001; difference = 0.052, 95% CI = 0.017 - 0.158, p < 0.0001, respectively). Conclusions: These results from a haplotype analysis show for the first time that genetic combinations of alleles of the FABP-2 and PPAR-γ gene could play a role in the susceptibility to develop dyslipemia in T2DM.Fil: Siewert, Susana Elfrida. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas. Laboratorio de Diabetes; ArgentinaFil: Olmos Nicotra, Maria Florencia. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas. Laboratorio de Diabetes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gonzalez, Irma Ines. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas. Laboratorio de Diabetes; ArgentinaFil: Fernandez, Gustavo. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas. Laboratorio de Diabetes; ArgentinaFil: Ojeda, Marta Susana. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas. Laboratorio de Diabetes; Argentin

Fear of Hazards in Commodity Futures Markets

We examine the commodity futures pricing role of active attention to weather, disease,geopolitical or economic threats or “hazard fear” as proxied by the volume of internet searches by 149 query terms. A long-short portfolio strategy that sorts the cross-section of commodity futures contracts according to a hazard fear signal captures a significant premium. This commodity hazard fear premium reflects compensation for extant fundamental, tail, volatility and liquidity risks factors, but it is not subsumed by them. Exposure to hazard-fear is strongly priced in the cross-section of commodity portfolios. The hazard fear premium exacerbates during periods of adverse sentiment or pessimism in financial markets

Towards the design of universal immunosurfaces for SPR-based assays: A review

Surface biofunctionalization, including chemical activation and attachment of the bioreceptor, is an essential step to provide reliable detection of biomolecular binding events monitored by Surface Plasmon Resonance (SPR), the most employed optical biosensor, and other biosensor techniques. Recent progress in the area of immobilization procedures are aimed at producing reproducible interfacial surfaces that enable the sensitive and specific recognition of the analyte. Antibodies are still the most employed bioreceptors for SPR assays. A wide range of strategies have been proposed to maximize the SPR immunosensor performance by controlling the stability and orientation of the immobilized antibody. This article reviews the most recent advancements in random and oriented antibody immobilization approaches for SPR biosensing applications, with a special focus on the research that have been done to find universal linkers, which can allow the use of the same functionalized surface for different applications.S

Insect marks on bones from La Guillerma archaeological locality (Salado river depression, Buenos Aires, Argentina)

The La Guillerma archaeological locality is located in the northeast sector of Buenos Aires province (Argentina). Two of its sites (LG1 and LG5), dated between ca. 1400-and 600-years BP, have a great amount of faunal remains including deer, rodents, fish and small birds that are subjected to taphonomic agents and processes (e.g., weathering, manganese, roots). Previous studies have shown osteophagic behaviour in different insects (e.g., Coleoptera, Blattodea). In this paper, we evaluate their incidence on La Guillerma faunal assemblage. We performed an analysis on marks that were identified in bone remains of various taxa and applied the criteria for identifying bone alteration by insects (i.e., by measuring each trace and comparing them with the types of insect marks described in the literature). Fifteen specimens (LG1 = 6 and LG5 = 9) exhibited different types of modifications (e.g., pits with striae in base, pits with emanating striae, striations) that are related to the action of insects. Although the proportion of affected bones is low in relation to the total sample, we highlight our study as the first detailed analysis of insect marks on archaeological bones from Argentina. We also emphasize the significance of addressing insect-produced modifications on Argentinean archaeological sites.Fil: Escosteguy, Paula Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Filosofía y Letras. Instituto de Arqueología; ArgentinaFil: Fernandez, Alejandro Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Filosofía y Letras. Instituto de Arqueología; ArgentinaFil: Gonzalez, Maria Isabel. Universidad de Buenos Aires. Facultad de Filosofía y Letras. Instituto de Arqueología; Argentin

Teaching based on the case method of building collective protection

One of the fundamental aspects in the adaptation of the teaching to the European higher education is changing based models of teacher education to models based on student learning. In this work we present an educational experience developed with the teaching method based on the case method, with a clearly multidisciplinary. The experience has been developed in the teaching of analysis and verification of safety rails. This is a multidisciplinary field that presents great difficulties during their teaching. The use of the case method has given good results in the competences achieved by student

Analysis of teaching experience based on teaching by the case method. Application to reinforcing wooden floors

The technique of reinforcement of wooden floors is a matter clearly multidisciplinary. The teaching of the subject using the "traditional" method, explaining the theory first and then proposing and solving problems has not been successful. This paper discusses the results of a teaching experiencie. It has been the teaching of the subject by the case method. The results are clearly superior to those obtained with the traditional methodology

Tren de palabras - La escritura de Fernando del Paso

Tren de palabras. La escritura de Fernando del Paso recoge seis ensayos y una entrevista a cargo de cuatro estudiosos de la obra delpasiana; el sello es alumbrar nuevas perspectivas, encarar las omisiones y acrecentar el diálogo, bien argumentado, que abone a una comprensión mejor de esta abrumadora y desbordante literatura, ínsula en sí misma.Universidad Autónoma del Estado de México, UAEM

Análisis de experiencias de laboratorio como herramienta docente: aplicación al estudio de pilares de hormigón reforzados mediante encamisados

El Grupo de Innovación Educativa de la Universidad Politécnica de Madrid Enseñanza del Hormigón Estructural (EHE) está desarrollando un Proyecto de Innovación Educativa (PIE)basado en la elaboracióde casos prácticos. En este trabajo se estudia un caso práctico relativo al análisis de refuerzos de pilares de hormigón armado mediante encamisados metálicos y de hormigón. El estudio se ha desarrollado tomando como base los datos experimentales publicados acerca del refuerzo de pilares con encamisados metálicos y de hormigón frente al comportamiento de pilares patrón

The use of geographic information systems for the optimal location of biomass power plants in the Madrid Community (Spain)

This article has been extracted from the results of a thesis entitled “Potential bioelectricity production of the Madrid Community Agricultural Regions based on rye and triticale biomass.” The aim was, first, to quantify the potential of rye (Secale Cereale L.) and triticale ( Triticosecale Aestivum L.) biomass in each of the Madrid Community agricultural regions, and second, to locate the most suitable areas for the installation of power plants using biomass. At least 17,339.9 t d.m. of rye and triticale would be required to satisfy the biomass needs of a 2.2 MW power plant, (considering an efficiency of 21.5%, 8,000 expected operating hours/year and a biomass LCP of 4,060 kcal/kg for both crops), and 2,577 ha would be used (which represent 2.79% of the Madrid Community fallow dry land surface). Biomass yields that could be achieved in Madrid Community using 50% of the fallow dry land surface (46,150 ha representing 5.75% of the Community area), based on rye and triticale crops, are estimated at 84,855, 74,906, 70,109, 50,791, 13,481, and 943 t annually for the Campiña, Vegas, Sur Occidental, Área Metropolitana, Lozoya-Somosierra, and Guadarrama regions. The latter represents a bioelectricity potential of 10.77, 9.5, 8.9, 6.44, 1.71, and 0.12 MW, respectively

Metabolic risk score indexes validation in overweight healthy people

The constellation of adverse cardiovascular disease (CVD) and metabolic risk factors, including elevated abdominal obesity, blood pressure (BP), glucose, and triglycerides (TG) and lowered high-density lipoprotein-cholesterol (HDL-C), has been termed the metabolic syndrome (MetSyn) [1]. A number of different definitions have been developed by the World Health Organization (WHO) [2], the National Cholesterol Education Program Adult Treatment Panel III (ATP III) [3], the European Group for the Study of Insulin Resistance (EGIR) [4] and, most recently, the International Diabetes Federation (IDF) [5]. Since there is no universal definition of the Metabolic Syndrome, several authors have derived different risk scores to represent the clustering of its components [6-11]