Lifestyle choices of Brazilian college students

Lifestyle choices reflect the beliefs that individuals attribute to aspects of life. This construct can be assessed with the Individual Lifestyle Profile (PEVI) questionnaire, which measures elements of Nutrition, Physical Activity, Preventive Behaviors, Social Relationships and Stress Management.info:eu-repo/semantics/publishedVersio

Early psychological impact of the COVID-19 pandemic in Brazil: A sational survey

Isolation measures used to contain epidemics generate social interaction restrictions and impose changes in routines of the public that increase negative psychological outcomes. Anxiety and depression are the most common symptoms.info:eu-repo/semantics/publishedVersio

ETHE1 and MOCS1 deficiencies : disruption of mitochondrial bioenergetics, dynamics, redox homeostasis and endoplasmic reticulum-mitochondria crosstalk in patient fibroblasts

Ethylmalonic encephalopathy protein 1 (ETHE1) and molybdenum cofactor (MoCo) defciencies are hereditary disorders that afect the catabolism of sulfur-containing amino acids. ETHE1 defciency is caused by mutations in the ETHE1 gene, while MoCo defciency is due to mutations in one of three genes involved in MoCo biosynthesis (MOCS1, MOCS2 and GPHN). Patients with both disorders exhibit abnormalities of the mitochondrial respiratory chain, among other biochemical fndings. However, the pathophysiology of the defects has not been elucidated. To characterize cellular derangements, mitochondrial bioenergetics, dynamics, endoplasmic reticulum (ER)-mitochondria communication, superoxide production and apoptosis were evaluated in fbroblasts from four patients with ETHE1 defciency and one with MOCS1 defciency. The efect of JP4-039, a promising mitochondrial-targeted antioxidant, was also tested on cells. Our data show that mitochondrial respiration was decreased in all patient cell lines. ATP depletion and increased mitochondrial mass was identifed in the same cells, while variable alterations in mitochondrial fusion and fssion were seen. High superoxide levels were found in all cells and were decreased by treatment with JP4-039, while the respiratory chain activity was increased by this antioxidant in cells in which it was impaired. The content of VDAC1 and IP3R, proteins involved in ER-mitochondria communication, was decreased, while DDIT3, a marker of ER stress, and apoptosis were increased in all cell lines. These data demonstrate that previously unrecognized broad disturbances of cellular function are involved in the pathophysiology of ETHE1 and MOCS1 defciencies, and that reduction of mitochondrial superoxide by JP4-039 is a promising strategy for adjuvant therapy of these disorders

Subjective wellbeing of preschool children

Objective: The aim of the present study was to evaluate the psychometric properties of the Autoquestionnaire Qualité de Vie Enfant Imagé (AUQEI) in pre-school children and estimate the influence of demographic characteristics on their subjective wellbeing. Methods: Construct validity was estimated using confirmatory analysis and the chi-square per degrees of freedom ratio (χ2/df), Comparative Fit Index (CFI), Tucker-Lewis Index (TLI), and Root Mean Square Error of Approximation (RMSEA). Reliability was assessed by the ordinal alpha (α) and omega (ω) coefficients and the factorial invariance by the difference in CFI (ΔCFI). Mean scores for each AUQEI item and the general score were calculated. Results: A total of 443 Preschool children enrolled in public education institutions participated. The original 4-factor AUQEI model showed collinearity between factors and a high correlation between two items. A single factor model was tested, presenting adequate fit to the data (χ2/df = 4.47; CFI = 0.98; TLI = 0.98; RMSEA = 0.08; α = 0.98; ω = 0.93; UniCo > 0.95, EVC > 0.85, and MIREAL 0.05). Conclusions: The assessment of subjective wellbeing with the single-factor AUQEI model provided valid, reliable, and invariant. Thus, being a relevant and interesting instrument to assess wellbeing in young children.Peer reviewe

Concern of primiparous women with regard to labor and birth

Objective: Recognizing the concerns of primiparous women about labor and birth, the nurse identify actions to mitigating the feelings of women. Method: this was a descriptive, exploratory research, qualitative in nature, with six primiparous women rooming at the University Hospital Antonio Pedro through semistructured interviews and analyzed with the principles of thematic analysis, after approval by the Ethics Committee of the University Hospital Antonio Pedro, under nº 218 283. Results: in the data analysis, the results showed their feelings and expectations regarding their relationship with labor and birth, such as fear, insecurity and anxiety. However, the presence of a companion proved to be important for inhibition of these feelings. Conclusion: the health professional should facilitate and promote care to the mother, with a resulting assistance of a trust and bond

Desenvolvimento e validação de metodologia analítica para a determinação do teor de ácido glicólico na matéria-prima e em formulações dermocosméticas

Glycolic acid is widely used in therapeutical care as a soft peeling, leading to the thickness of the horny layer, which is useful in the renewal of the epidermis and the reduction of the face lines. However, in high concentrations it can be associated to a potential of irritation of the skin. A chemical peeling has diverse clinical applications, among them the treatment of injured skin face like: acne, ichthyose, melasma, warts and other else. The present work had the goal to establish and to validate an analytical methodology for the determination of the glycolic acid purity in the raw material and in the dermocosmetic formulations, the acid-base neutralization titration method was used, and the end point was determined with visual indicator as well as potenciometric. The analysis of glycolic acid in the raw material, and particularly, in the finished product is important to maintain the quality control and to guarantee the consumers security. Therefore, the raw material and the products, with glycolic acid, were analyzed in two days, as its purity in free and total glycolic acid was determined using sodium hydroxide 0,1 N and the hydrochloric acid 0,1 N solutions. The developed methodology was based on the reaction with the active substance and with the property characteristics of these formulations. It was demonstrated to be practical and efficient in quantify the glycolic acid.O ácido glicólico é amplamente utilizado na terapêutica para se obter um peeling suave, levando ao afinamento do estrato córneo útil na renovação da epiderme e na redução das linhas faciais. Porém, em concentrações elevadas pode estar associado a um alto potencial de irritação da pele. O peeling químico tem diversas aplicações clínicas dentre elas o tratamento da pele facial lesada por problemas como acne, ictiose, melasma, verrugas e outros problemas. O presente trabalho objetivou estabelecer e validar a metodologia analítica para a determinação do teor de ácido glicólico na matéria-prima e em formulações dermocosméticas, tendo empregado o método titulométrico de neutralização ácido-base, determinando-se o ponto de equivalência com indicador e/ou indicação potenciométrica. A análise do teor de ácido glicólico na matéria-prima e, particularmente, no produto acabado, é importante para o controle de qualidade, principalmente, para a segurança dos consumidores. Portanto, a matéria-prima e os produtos, contendo ácido glicólico, foram analisados em dois dias, quanto ao teor de ácido glicólico livre e total utilizando soluções de hidróxido de sódio 0,1 N e o ácido clorídrico 0,1 N. A metodologia desenvolvida baseou-se na reação com a substância ativa e com as características próprias destas formulações, demonstrando ser prática e eficaz na quantificação do ácido glicólico

The evolution of the density of galaxy clusters and groups: denser environments at higher redshifts

We show that, observationally, the projected local density distribution in high-z clusters is shifted towards higher values compared to clusters at lower redshift. To search for the origin of this evolution, we analyze a sample of haloes selected from the Millennium Simulation and populated using semi-analytic models, investigating the relation between observed projected density and physical 3D density, using densities computed from the 10 and 3 closest neighbours. Both observationally and in the simulations, we study the relation between number of cluster members and cluster mass, and number of members per unit of cluster mass. We find that the observed evolution of projected densities reflects a shift to higher values of the physical 3D density distribution. In turn, this must be related with the globally higher number of galaxies per unit of cluster volume N/V in the past. We show that the evolution of N/V is due to a combination of two effects: a) distant clusters were denser in dark matter (DM) simply because the DM density within R_{200} (~the cluster virial radius) is defined to be a fixed multiple of the critical density of the Universe, and b) the number of galaxies per unit of cluster DM mass is remarkably constant both with redshift and cluster mass if counting galaxies brighter than a passively evolving magnitude limit. Our results highlight that distant clusters were much denser environments than today's clusters, both in galaxy number and mass, and that the density conditions felt by galaxies in virialized systems do not depend on the system mass.Comment: accepted for publication in MNRA

The importance of the local density in shaping the galaxy stellar mass functions

Exploiting the capabilities of four different surveys --- the Padova-Millennium Galaxy and Group Catalogue (PM2GC), the WIde-field Nearby Galaxy-cluster Survey (WINGS), the IMACS Cluster Building Survey (ICBS) and the ESO Distant Cluster Survey (EDisCS) --- we analyze the galaxy stellar mass distribution as a function of local density in mass-limited samples, in the field and in clusters from low (z>0.04) to high (z<0.8) redshift. We find that at all redshifts and in all environments, local density plays a role in shaping the mass distribution. In the field, it regulates the shape of the mass function at any mass above the mass limits. In clusters, it seems to be important only at low masses (log M_ast/M_sun <10.1 in WINGS and log M_ast/M_sun < 10.4 in EDisCS), otherwise it seems not to influence the mass distribution. Putting together our results with those of Calvi et al. and Vulcani et al. for the global environment, we argue that at least at $z\leq 0.8$ local density is more important than global environment in determining the galaxy stellar mass distribution, suggesting that galaxy properties are not much dependent of halo mass, but do depend on local scale processes.Comment: MNRAS accepted, in pres