Hacia una ontología de razonamiento pedagógico para la recomendación de estrategias didácticas mediadas por TIC

Este trabajo presenta los avances preliminares obtenidos en la construcción de una ontología para el razonamiento pedagógico. La ontología tiene como objetivo la recomendación de estrategias didácticas mediadas por TIC a los docentes que utilizan dispositivos electrónicos como mediadores de procesos de enseñanza y aprendizaje

CONDUCTAS PROTECTORAS PARA EVITAR ENFERMEDADES DE TRANSMISIÓN SEXUAL EN ADOLESCENTES DEL COLEGIO “SANTA MAGDALENA SOFÍA” - CHICLAYO 2019

La presente investigación tuvo como objetivo determinar las conductas protectoras para evitar enfermedades de transmisión sexual en adolescentes del colegio “Santa Magdalena Sofía” – Chiclayo 2019. Se realizó un estudio de tipo cuantitativo y descriptivo con un diseño transversal y no experimental. La muestra estuvo comprendida por 120 alumnas del quinto grado de secundaria de las aulas A, B, C y D que fueron encuestadas y colaboraron voluntariamente respondiendo a un cuestionario sobre las conductas protectoras en el inicio de su vida sexual, conocimiento de las ETS y empleo de métodos anticonceptivos para evitar enfermedades de transmisión sexual. Los resultados mostraron que, entre las edades de 15 y 17 años, un 66.7% iniciaron la vida sexual a los 15 años. Se identificó que más de la mitad de las encuestadas utilizan métodos anticonceptivos y que un porcentaje menor no las utiliza; asimismo la mayoría de las encuestadas recibe escasa información sobre las enfermedades de transmisión sexual. Se concluye que las conductas protectoras y las influencias interpersonales en las adolescentes son importantes ante los riesgos que contraen las enfermedades de transmisión sexual

Synthesis of quinoxaline 1,4-di-N-oxide derivatives on solid support using room temperature and microwave-assisted solvent-free procedures

We describe the synthesis of 12 new ethyl and methyl quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives on solid supports with room temperature and microwave-assisted solvent-free procedures. Results show that solid supports have good catalytic activity in the formation of quinoxaline 1,4-di-N-oxide derivatives. We found that florisil and montmorillonite KSF and K10 could be used as new, easily available, inexpensive alternatives of catalysts. Additionally, room temperature and microwave-irradiation solvent-free synthesis was more efficient than a conventional procedure (Beirut reaction), reducing reaction time and increasing yield

Repair of complete bilateral cleft lip with severely protruding premaxilla performing a premaxillary setback and vomerine ostectomy in one stage surgery

Background: The authors present a technique for selected cases of CBCL. The primary repair of the CBCL with a severely protruding premaxilla in one stage surgery is very difficult, essentially because a good muscular apposition is difficult, forcing synchronously to do a premaxillary setback to facilitate subsequent bilateral lip repair and, thus, achieving satisfactory results. We achieve this by a reductive ostectomy on the vomero- premaxillary suture. Material and Methods: 4 patients with CBCL and severely protruding premaxilla underwent premaxillary setback by vomerine ostectomy at the same time of lip repair in the past 24 months. The extent of premaxillary setback varied between 9 and 16 mm. The required amount of bone was removed anterior to the vomero-premaxillary suture. The authors did an additional simultaneous gingivoperiosteoplasty in all patients, achieving an enough stability of the premaxilla in its new position, to be able to close the alveolar gap bilaterally. The authors have examined the position of premaxilla and dental arch between 6 and 24 months. We did not do the primary nose correction, because this increased the risk of impairment of the already compromised vascularity of the philtrum and premaxilla. Results : The follow-up period ranged between 6 and 24 months. None of the patients had any major complication. During follow-up, the premaxilla was minimally mobile. We achieved a good lip repair in all cases: adequate muscle repair, symmetry of the lip, prolabium and Cupid’s bow, as well as good scars. Conclusions : To our knowledge, there are few reports of one stage surgery with vomerine ostectomy to repair CBCL with severely protruding premaxilla. Doing this vomerine ostectomy, we don’t know how it will affect the subsequent growth of the premaxila and restrict the natural maxillary growth. Applying this alternative treatment for children with CBCL and protruded premaxilla without any preoperative orthopedic, we can successfully perform, in a single-stage surgery, a good primary lip repair at our center. Further confirmations of this surgery with follow up and anthropometric studies of these patients during childhood and adolescence are require

Characterization of New TRPM8 Modulators in Pain Perception

Background: Transient Receptor Potential Melastatin-8 (TRPM8) is a non-selective cation channel activated by cold temperature and by cooling agents. Several studies have proved that this channel is involved in pain perception. Although some studies indicate that TRPM8 inhibition is necessary to reduce acute and chronic pain, it is also reported that TRPM8 activation produces analgesia. These conflicting results could be explained by extracellular Ca2+-dependent desensitization that is induced by an excessive activation. Likely, this effect is due to phosphatidylinositol 4,5-bisphosphate (PIP2) depletion that leads to modification of TRPM8 channel activity, shifting voltage dependence towards more positive potentials. This phenomenon needs further evaluation and confirmation that would allow us to understand better the role of this channel and to develop new therapeutic strategies for controlling pain. Experimental approach: To understand the role of TRPM8 in pain perception, we tested two specific TRPM8-modulating compounds, an antagonist (IGM-18) and an agonist (IGM-5), in either acute or chronic animal pain models using male Sprague-Dawley rats or CD1 mice, after systemic or topical routes of administration. Results: IGM-18 and IGM-5 were fully characterized in vivo. The wet-dog shake test and the body temperature measurements highlighted the antagonist activity of IGM-18 on TRPM8 channels. Moreover, IGM-18 exerted an analgesic effect on formalin-induced orofacial pain and chronic constriction injury-induced neuropathic pain, demonstrating the involvement of TRPM8 channels in these two pain models. Finally, the results were consistent with TRPM8 downregulation by agonist IGM-5, due to its excessive activation. Conclusions: TRPM8 channels are strongly involved in pain modulation, and their selective antagonist is able to reduce both acute and chronic pain

Criterios de implementación ISO 14001:2015 Caso estudio sector reciclaje, en Tunja.

Criterios de implementación ISO 14001:2015 Caso estudio sector reciclaje, en Tunja.El desarrollo del presente Estudio de caso tiene como objetivo principal realizar la auditoria interna de la norma NTC ISO 14001:2015 realizada a la empresa Recitunja, empresa que se dedica a la recolección, clasificación, transformación y comercialización de materiales aprovechables para su reciclaje.The main objective of this case study is to carry out the internal audit of the NTC ISO 14001: 2015 standard made to the company Recitunja, a company that is dedicated to the collection, classification, transformation and commercialization of usable materials for recycling

Las prácticas pedagógicas del español como lengua extranjera en dos universidades colombianas

En este artículo se presenta la investigación realizada por investigadores de la Universidad Santo Tomás de Bogotá y la Pontificia Bolivariana de Medellín sobre las prácticas docentes y los recursos didácticos utilizados en las clases de ELE. Éste es un estudio cualitativo, de carácter descriptivo/etnográfico y se realizó de la siguiente manera: Se seleccionaron y analizaron los recursos didácticos en ELE, se hizo la aplicación de los instrumentos, la triangulación hermenéutica y el análisis de la información.  Los resultados de este estudio se derivan en tres categorías: Las prácticas pedagógicas, el uso de los recursos didácticos y la inclusión del componente cultural