Improved IEEE 802.11 point coordination function considering fiber-delay difference in distributed antenna systems

In this paper, we present an improved IEEE 802.11 wireless local-area network (WLAN) medium access control (MAC) mechanism for simulcast radio-over-fiber-based distributed antenna systems where multiple remote antenna units (RAUs) are connected to one access point (AP). In the improved mechanism, the fiber delay between RAUs and central unit is taken into account in a modification to the conventional point coordination function (PCF) that achieves coordination by a centralized algorithm. Simulation results show that the improved PCF outperforms the distributed coordination function (DCF) in both the basic-access and request/clear-to-send modes in terms of the total throughput and the fairness among RAU

Tip-enhanced Raman scattering of DNA aptamers for Listeria monocytogenes

Optical detection and conformational mapping of aptamers are important for improving medical and biosensing technologies and for better understanding of biological processes at the molecular level. The authors investigate the vibrational signals of deoxyribonucleic acid aptamers specific to Listeria monocytogenes immobilized on gold substrates using tip-enhanced Raman scattering (TERS) spectroscopy and nanoscale imaging. The authors compare topographic and nano-optical signals and investigate the fluctuations of the position-dependent TERS spectra. They perform spatial TERS mapping with 3 nm step size and discuss the limitation of the resulting spatial resolution under the ambient conditions. TERS mapping provides information about the chemical composition and conformation of aptamers and paves the way to future label-free biosensing

Solving non-abelian loop Toda equations

We construct soliton solutions for non-abelian loop Toda equations associated with general linear groups. Here we consider the untwisted case only and use the rational dressing method based upon appropriate block-matrix representation suggested by the initial \bbZ-gradation.Comment: 28 page

Red Blood Cell Transfusion Strategy for Upper Gastrointestinal Bleeding

Acute upper gastrointestinal bleeding (UGIB) is a potentially lethal and frequent digestive disease. It is mainly divided into the nonvariceal UGIB and variceal bleeding according to the source of bleeding. Red blood cell transfusion is the core therapeutic option for the management of acute UGIB. In this chapter, we reviewed the primary evidence from meta‐analyses and large‐scale randomized controlled trials regarding red blood cell transfusion strategy for acute UGIB

Intelligent Scheduling Method for Bulk Cargo Terminal Loading Process Based on Deep Reinforcement Learning

Funding Information: Funding: This research was funded by the National Natural Science Foundation of China under Grant U1964201 and Grant U21B6001, the Major Scientific and Technological Special Project of Hei-longjiang Province under Grant 2021ZX05A01, the Heilongjiang Natural Science Foundation under Grant LH2019F020, and the Major Scientific and Technological Research Project of Ningbo under Grant 2021Z040. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.Sea freight is one of the most important ways for the transportation and distribution of coal and other bulk cargo. This paper proposes a method for optimizing the scheduling efficiency of the bulk cargo loading process based on deep reinforcement learning. The process includes a large number of states and possible choices that need to be taken into account, which are currently performed by skillful scheduling engineers on site. In terms of modeling, we extracted important information based on actual working data of the terminal to form the state space of the model. The yard information and the demand information of the ship are also considered. The scheduling output of each convey path from the yard to the cabin is the action of the agent. To avoid conflicts of occupying one machine at same time, certain restrictions are placed on whether the action can be executed. Based on Double DQN, an improved deep reinforcement learning method is proposed with a fully connected network structure and selected action sets according to the value of the network and the occupancy status of environment. To make the network converge more quickly, an improved new epsilon-greedy exploration strategy is also proposed, which uses different exploration rates for completely random selection and feasible random selection of actions. After training, an improved scheduling result is obtained when the tasks arrive randomly and the yard state is random. An important contribution of this paper is to integrate the useful features of the working time of the bulk cargo terminal into a state set, divide the scheduling process into discrete actions, and then reduce the scheduling problem into simple inputs and outputs. Another major contribution of this article is the design of a reinforcement learning algorithm for the bulk cargo terminal scheduling problem, and the training efficiency of the proposed algorithm is improved, which provides a practical example for solving bulk cargo terminal scheduling problems using reinforcement learning.publishersversionpublishe

DIMP53-1:A novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties

The transcription factor p53 plays a crucial role in cancer development and dissemination, and thus, p53-targeted therapies are among the most encouraging anticancer strategies. In human cancers with wild-type (wt) p53, its inactivation by interaction with murine double minute (MDM)2 and MDMX is a common event. Simultaneous inhibition of the p53 interaction with both MDMs is crucial to restore the tumor suppressor activity of p53. Here, we describe the synthesis of the new tryptophanol-derived oxazoloisoindolinone DIMP53-1 and identify its activity as a dual inhibitor of the p53-MDM2/X interactions using a yeast-based assay. DIMP53-1 caused growth inhibition, mediated by p53 stabilization and upregulation of p53 transcriptional targets involved in cell cycle arrest and apoptosis, in wt p53-expressing tumor cells, including MDM2- or MDMX-overexpressing cells. Importantly, DIMP53-1 inhibits the p53-MDM2/X interactions by potentially binding to p53, in human colon adenocarcinoma HCT116 cells. DIMP53-1 also inhibited the migration and invasion of HCT116 cells, and the migration and tube formation of HMVEC-D endothelial cells. Notably, in human tumor xenograft mice models, DIMP53-1 showed a p53-dependent antitumor activity through induction of apoptosis and inhibition of proliferation and angiogenesis. Finally, no genotoxicity or undesirable toxic effects were observed with DIMP53-1. In conclusion, DIMP53-1 is a novel p53 activator, which potentially binds to p53 inhibiting its interaction with MDM2 and MDMX. Although target-directed, DIMP53-1 has a multifunctional activity, targeting major hallmarks of cancer through its antiproliferative, proapoptotic, antiangiogenic, anti-invasive, and antimigratory properties. DIMP53-1 is a promising anticancer drug candidate and an encouraging starting point to develop improved derivatives for clinical application

Origin and Dynamical Evolution of Neptune Trojans - I: Formation and Planetary Migration

We present the results of detailed dynamical simulations of the effect of the migration of the four giant planets on both the transport of pre-formed Neptune Trojans, and the capture of new Trojans from a trans-Neptunian disk. We find that scenarios involving the slow migration of Neptune over a large distance (50Myr to migrate from 18.1AU to its current location) provide the best match to the properties of the known Trojans. Scenarios with faster migration (5Myr), and those in which Neptune migrates from 23.1AU to its current location, fail to adequately reproduce the current day Trojan population. Scenarios which avoid disruptive perturbation events between Uranus and Neptune fail to yield any significant excitation of pre-formed Trojans (transported with efficiencies between 30 and 98% whilst maintaining the dynamically cold nature of these objects). Conversely, scenarios with periods of strong Uranus-Neptune perturbation lead to the almost complete loss of such pre-formed objects. In these cases, a small fraction (~0.15%) of these escaped objects are later recaptured as Trojans prior to the end of migration, with a wide range of eccentricities (<0.35) and inclinations (<40 deg). In all scenarios (including those with such disruptive interaction between Uranus and Neptune) the capture of objects from the trans-Neptunian disk (through which Neptune migrates) is achieved with efficiencies between ~0.1 and ~1%. The captured Trojans display a wide range of inclinations (<40 deg for slow migration, and <20 deg for rapid migration) and eccentricities (<0.35), and we conclude that, given the vast amount of material which undoubtedly formed beyond the orbit of Neptune, such captured objects may be sufficient to explain the entire Neptune Trojan population. (Shortened version)Comment: 25 pages, 6 figure

Atomically controlled, self-limiting procedures for growth of aluminum oxide on SiC-on-Si

Abstract number 0451, Abstract book page P-02-008Electronic devices fabricated from SiC/Si epitaxial wafers will need surface passivation and insulating coatings. For solar cell applications – and in MOS systems – Al-oxide thin film coatings have some strong advocates, not the least due to the advances of the ALD process. We have grown SiC/Si, formed by a remote CH4 plasma interacting with Si surfaces in UHV. After growing the SiC/Si system (SiC thickness between 0.5 and 5 nm; polycrystalline) a self-limiting Si-oxide layer was grown on the surface, with a thickness of around 1 nm, at 7000C. On top of this layer we deposited approximately 1 nm of Al with a Knudsen atomic source (all steps in UHV) and then reacted it thermally (at 6000C) with the Si-oxide. We monitored all the process steps and the resulting structures of the layers and the interface using synchrotron radiation induced core level photoemission at ASTRID, Aarhus, Denmark. We found similar qualities with this procedure, as for Si, i.e. an atomically sharp interface between Al-oxide and SiC, and this reaction scheme offers self-limiting behavior both of the oxidation to create Si-oxide, and to the conversion into Al-oxide, which only needs a sufficient amount of Al to affect the total conversion of the Si-oxide, while excess Al will leave the system at sufficiently elevated temperatures.publishersversionpublishe