278 research outputs found
Transverse Spin Structure of the Nucleon through Target Single Spin Asymmetry in Semi-Inclusive Deep-Inelastic Reaction at Jefferson Lab
Jefferson Lab (JLab) 12 GeV energy upgrade provides a golden opportunity to
perform precision studies of the transverse spin and
transverse-momentum-dependent structure in the valence quark region for both
the proton and the neutron. In this paper, we focus our discussion on a
recently approved experiment on the neutron as an example of the precision
studies planned at JLab. The new experiment will perform precision measurements
of target Single Spin Asymmetries (SSA) from semi-inclusive electro-production
of charged pions from a 40-cm long transversely polarized He target in
Deep-Inelastic-Scattering kinematics using 11 and 8.8 GeV electron beams. This
new coincidence experiment in Hall A will employ a newly proposed solenoid
spectrometer (SoLID). The large acceptance spectrometer and the high polarized
luminosity will provide precise 4-D (, , and ) data on the
Collins, Sivers, and pretzelocity asymmetries for the neutron through the
azimuthal angular dependence. The full 2 azimuthal angular coverage in the
lab is essential in controlling the systematic uncertainties. The results from
this experiment, when combined with the proton Collins asymmetry measurement
and the Collins fragmentation function determined from the ee collision
data, will allow for a quark flavor separation in order to achieve a
determination of the tensor charge of the d quark to a 10% accuracy. The
extracted Sivers and pretzelocity asymmetries will provide important
information to understand the correlations between the quark orbital angular
momentum and the nucleon spin and between the quark spin and nucleon spin.Comment: 23 pages, 13 figures, minor corrections, matches published versio
Coherent states for the hydrogen atom
We construct wave packets for the hydrogen atom labelled by the classical
action-angle variables with the following properties. i) The time evolution is
exactly given by classical evolution of the angle variables. (The angle
variable corresponding to the position on the orbit is now non-compact and we
do not get exactly the same state after one period. However the gross features
do not change. In particular the wave packet remains peaked around the labels.)
ii) Resolution of identity using this overcomplete set involves exactly the
classical phase space measure. iii) Semi-classical limit is related to
Bohr-Sommerfield quantization. iv) They are almost minimum uncertainty wave
packets in position and momentum.Comment: 9 pages, 2 figures, minor change in language and journal reference
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Pin1 and neurodegeneration: a new player for prion disorders?
Pin1 is a peptidyl-prolyl isomerase that catalyzes the cis/trans conversion of phosphorylated proteins at serine or threonine residues which precede a proline. The peptidyl-prolyl isomerization induces a conformational change of the proteins involved in cell signaling process. Pin1 dysregulation has been associated with some neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and Huntington's disease. Proline-directed phosphorylation is a common regulator of these pathologies and a recent work showed that it is also involved in prion disorders. In fact, prion protein phosphorylation at the Ser-43-Pro motif induces prion protein conversion into a disease-associated form. Furthermore, phosphorylation at Ser-43-Pro has been observed to increase in the cerebral spinal fluid of sporadic Creutzfeldt-Jakob Disease patients. These findings provide new insights into the pathogenesis of prion disorders, suggesting Pin1 as a potential new player in the disease. In this paper, we review the mechanisms underlying Pin1 involvement in the aforementioned neurodegenerative pathologies focusing on the potential role of Pin1 in prion disorders
MicroMotility: State of the art, recent accomplishments and perspectives on the mathematical modeling of bio-motility at microscopic scales
Mathematical modeling and quantitative study of biological motility (in particular, of motility at microscopic scales) is producing new biophysical insight and is offering opportunities for new discoveries at the level of both fundamental science and technology. These range from the explanation of how complex behavior at the level of a single organism emerges from body architecture, to the understanding of collective phenomena in groups of organisms and tissues, and of how these forms of swarm intelligence can be controlled and harnessed in engineering applications, to the elucidation of processes of fundamental biological relevance at the cellular and sub-cellular level. In this paper, some of the most exciting new developments in the fields of locomotion of unicellular organisms, of soft adhesive locomotion across scales, of the study of pore translocation properties of knotted DNA, of the development of synthetic active solid sheets, of the mechanics of the unjamming transition in dense cell collectives, of the mechanics of cell sheet folding in volvocalean algae, and of the self-propulsion of topological defects in active matter are discussed. For each of these topics, we provide a brief state of the art, an example of recent achievements, and some directions for future research
Significant locus and metabolic genetic correlations revealed in genome-wide association study of anorexia nervosa
OBJECTIVE: The authors conducted a genome-wide association study of anorexia nervosa and calculated genetic correlations with a series of psychiatric, educational, and metabolic phenotypes. METHOD: Following uniform quality control and imputation procedures using the 1000 Genomes Project (phase 3) in 12 case-control cohorts comprising 3,495 anorexia nervosa cases and 10,982 controls, the authors performed standard association analysis followed by a meta-analysis across cohorts. Linkage disequilibrium score regression was used to calculate genome-wide common variant heritability (single-nucleotide polymorphism [SNP]-based heritability [h2SNP]), partitioned heritability, and genetic correlations (rg) between anorexia nervosa and 159 other phenotypes. RESULTS: Results were obtained for 10,641,224 SNPs and insertion-deletion variants with minor allele frequencies >1% and imputation quality scores >0.6. The h2SNP of anorexia nervosa was 0.20 (SE=0.02), suggesting that a substantial fraction of the twin-based heritability arises from common genetic variation. The authors identified one genome-wide significant locus on chromosome 12 (rs4622308) in a region harboring a previously reported type 1 diabetes and autoimmune disorder locus. Significant positive genetic correlations were observed between anorexia nervosa and schizophrenia, neuroticism, educational attainment, and high-density lipoprotein cholesterol, and significant negative genetic correlations were observed between anorexia nervosa and body mass index, insulin, glucose, and lipid phenotypes. CONCLUSIONS: Anorexia nervosa is a complex heritable phenotype for which this study has uncovered the first genome-wide significant locus. Anorexia nervosa also has large and significant genetic correlations with both psychiatric phenotypes and metabolic traits. The study results encourage a reconceptualization of this frequently lethal disorder as one with both psychiatric and metabolic etiology
Genetic Association Analysis Using Sibship Data: A Multilevel Model Approach
Family based association study (FBAS) has the advantages of controlling for population stratification and testing for linkage and association simultaneously. We propose a retrospective multilevel model (rMLM) approach to analyze sibship data by using genotypic information as the dependent variable. Simulated data sets were generated using the simulation of linkage and association (SIMLA) program. We compared rMLM to sib transmission/disequilibrium test (S-TDT), sibling disequilibrium test (SDT), conditional logistic regression (CLR) and generalized estimation equations (GEE) on the measures of power, type I error, estimation bias and standard error. The results indicated that rMLM was a valid test of association in the presence of linkage using sibship data. The advantages of rMLM became more evident when the data contained concordant sibships. Compared to GEE, rMLM had less underestimated odds ratio (OR). Our results support the application of rMLM to detect gene-disease associations using sibship data. However, the risk of increasing type I error rate should be cautioned when there is association without linkage between the disease locus and the genotyped marker
Bivalirudin started during emergency transport for primary PCI.
BACKGROUND: Bivalirudin, as compared with heparin and glycoprotein IIb/IIIa inhibitors, has been shown to reduce rates of bleeding and death in patients undergoing primary percutaneous coronary intervention (PCI). Whether these benefits persist in contemporary practice characterized by prehospital initiation of treatment, optional use of glycoprotein IIb/IIIa inhibitors and novel P2Y12 inhibitors, and radial-artery PCI access use is unknown. METHODS: We randomly assigned 2218 patients with ST-segment elevation myocardial infarction (STEMI) who were being transported for primary PCI to receive either bivalirudin or unfractionated or low-molecular-weight heparin with optional glycoprotein IIb/IIIa inhibitors (control group). The primary outcome at 30 days was a composite of death or major bleeding not associated with coronary-artery bypass grafting (CABG), and the principal secondary outcome was a composite of death, reinfarction, or non-CABG major bleeding. RESULTS: Bivalirudin, as compared with the control intervention, reduced the risk of the primary outcome (5.1% vs. 8.5%; relative risk, 0.60; 95% confidence interval [CI], 0.43 to 0.82; P=0.001) and the principal secondary outcome (6.6% vs. 9.2%; relative risk, 0.72; 95% CI, 0.54 to 0.96; P=0.02). Bivalirudin also reduced the risk of major bleeding (2.6% vs. 6.0%; relative risk, 0.43; 95% CI, 0.28 to 0.66; P<0.001). The risk of acute stent thrombosis was higher with bivalirudin (1.1% vs. 0.2%; relative risk, 6.11; 95% CI, 1.37 to 27.24; P=0.007). There was no significant difference in rates of death (2.9% vs. 3.1%) or reinfarction (1.7% vs. 0.9%). Results were consistent across subgroups of patients. CONCLUSIONS: Bivalirudin, started during transport for primary PCI, improved 30-day clinical outcomes with a reduction in major bleeding but with an increase in acute stent thrombosis. (Funded by the Medicines Company; EUROMAX ClinicalTrials.gov number, NCT01087723.)
The Fermi GBM Gamma-Ray Burst Spectral Catalog: Four Years Of Data
In this catalog we present the updated set of spectral analyses of GRBs
detected by the Fermi Gamma-Ray Burst Monitor (GBM) during its first four years
of operation. It contains two types of spectra, time-integrated spectral fits
and spectral fits at the brightest time bin, from 943 triggered GRBs. Four
different spectral models were fitted to the data, resulting in a compendium of
more than 7500 spectra. The analysis was performed similarly, but not
identically to Goldstein et al. 2012. All 487 GRBs from the first two years
have been re-fitted using the same methodology as that of the 456 GRBs in years
three and four. We describe, in detail, our procedure and criteria for the
analysis, and present the results in the form of parameter distributions both
for the observer-frame and rest-frame quantities. The data files containing the
complete results are available from the High-Energy Astrophysics Science
Archive Research Center (HEASARC).Comment: Accepted for publication in ApJ
The Nuts and Bolts of Einstein-Maxwell Solutions
We find new non-supersymmetric solutions of five-dimensional ungauged
supergravity coupled to two vector multiplets. The solutions are regular,
horizonless and have the same asymptotic charges as non-extremal charged black
holes. An essential ingredient in our construction is a four-dimensional
Euclidean base which is a solution to Einstein-Maxwell equations. We construct
stationary solutions based on the Euclidean dyonic Reissner-Nordstrom black
hole as well as a six-parameter family with a dyonic Kerr-Newman-NUT base.
These solutions can be viewed as compactifications of eleven-dimensional
supergravity on a six-torus and we discuss their brane interpretation.Comment: 29 pages, 3 figure
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Health-related quality of life in patients with a germline BRCA mutation and metastatic pancreatic cancer receiving maintenance olaparib
Background: Patients with metastatic pancreatic cancer often have a detriment in health-related quality of life (HRQoL). In the randomized, double-blind, phase III POLO trial progression-free survival was significantly longer with maintenance olaparib, a poly(ADP-ribose) polymerase inhibitor, than placebo in patients with a germline BRCA1 and/or BRCA2 mutation (gBRCAm) and metastatic pancreatic cancer whose disease had not progressed during first-line platinum-based chemotherapy. The prespecified HRQoL evaluation is reported here. Patients and methods: Patients were randomized to receive maintenance olaparib (300 mg b.i.d.; tablets) or placebo. HRQoL was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30-item module at baseline, every 4 weeks until disease progression, at discontinuation, and 30 days after last dose. Scores ranged from 0 to 100; a ≥10-point change or difference between arms was considered clinically meaningful. Adjusted mean change from baseline was analysed using a mixed model for repeated measures. Time to sustained clinically meaningful deterioration (TSCMD) was analysed using a log-rank test. Results: Of 154 randomized patients, 89 of 92 olaparib-arm and 58 of 62 placebo-arm patients were included in HRQoL analyses. The adjusted mean change in Global Health Status (GHS) score from baseline was <10 points in both arms and there was no significant between-group difference [-2.47; 95% confidence interval (CI) -7.27, 2.33; P = 0.31]. Analysis of physical functioning scores showed a significant between-group difference (-4.45 points; 95% CI -8.75, -0.16; P = 0.04). There was no difference in TSCMD for olaparib versus placebo for GHS [P = 0.25; hazard ratio (HR) 0.72; 95% CI 0.41, 1.27] or physical functioning (P = 0.32; HR 1.38; 95% CI 0.73, 2.63). Conclusions: HRQoL was preserved with maintenance olaparib treatment with no clinically meaningful difference compared with placebo. These results support the observed efficacy benefit of maintenance olaparib in patients with a gBRCAm and metastatic pancreatic cancer. ClincalTrials.gov number: NCT02184195
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