Fluctuation Analysis of the Atmospheric Energy Cycle

The atmosphere gains available potential energy by solar radiation and dissipates kinetic energy mainly in the atmospheric boundary layer. We analyze the fluctuations of the global mean energy cycle defined by Lorenz (1955) in a simulation with a simplified hydrostatic model. The energy current densities are well approximated by the generalized Gumbel distribution (Bramwell, Holdsworth and Pinton, 1998) and the Generalized Extreme Value (GEV) distribution. In an attempt to assess the fluctuation relation of Evans, Cohen, and Morriss (1993) we define entropy production by the injected power and use the GEV location parameter as a reference state. The fluctuation ratio reveals a linear behavior in a finite range.Comment: 17 pages, 5 figure

Multigram scale synthesis of polycyclic lactones and evaluation of antitumor and other biological properties

YesAn efficient four-step synthesis of tetracyclic lactones from 1,4-benzodioxine-2-carboxylic acid was developed. Ellipticine derivatives exhibit antitumor activity however only a few derivatives without carbazole subunit have been studied to date. Herein, several tetracyclic lactones were synthesized and biologically evaluated. Several compounds (2a, 3a, 4a and 5a) were found to be inhibitors of the Kras-Wnt pathway. The lactone 2a also exerted a potent inhibition of Tau protein translation and was shown to have capacity for CYP1A1-bioactivation. The results obtained are further evidence of the therapeutic potential of tetracyclic lactones related to ellipticine. Molecular modeling studies showed that compound 2a is inserted between helix α3 and α4 of the KRas protein making interactions with the hydrophobic residues Phe90, Glu91, Ile9364, Hie94, Leu133 and Tyr137and a hydrogen bond with residue Arg97.The Spanish Minister (CTQ2011-29285-C02-02) the SGR(2014)-1017 Generalitat de Catalunya and the Laboratories Servier (France