Suicide in European Hodgkin Lymphoma Patients

The purpose of this study was to determine whether there is an increased risk of suicide in European Hodgkin Lymphoma (HL) patients compared to the general European population. European HL patients enrolled in the German Hodgkin Study Group (GHSG) HD7 through HD15 studies were analyzed and standardized mortality ratio (SMR) was calculated using suicide mortality rates for the general European population. Case-control analysis was performed to identify characteristics associated with risk of death by suicide. Among 12,202 European HL patients observed for 94,972 person-years, 19 suicides (17 males and 2 females) were identified resulting in a SMR 1.63 (95% CI: 1.01-2.50, p = 0.046). The only characteristic associated with a statistically significant increased risk of suicide was male sex with an odds ratio (OR) 8.42 (95% CI = 1.04-67.85; p = 0.046) on multivariate analysis. These findings were confirmed in an independently analyzed Surveillance, Epidemiology, and End Results Program (SEER) validation dataset. European HL patients have a significantly increased incidence of suicide compared to the general European population. Male HL patients have a greater than 8-fold increased risk of suicide compared to female HL patients. Further study of social risk factors associated with an increased risk of suicide in HL patients is needed

Regional climate hindcast simulations within EURO-CORDEX: evaluation of a WRF multi-physics ensemble

In the current work we present six hindcast WRF (Weather Research and Forecasting model) simulations for the EURO-CORDEX (European Coordinated Regional Climate Downscaling Experiment) domain with different configurations in microphysics, convection and radiation for the time period 1990?2008. All regional model simulations are forced by the ERA-Interim reanalysis and have the same spatial resolution (0.44°). These simulations are evaluated for surface temperature, precipitation, short- and longwave downward radiation at the surface and total cloud cover. The analysis of the WRF ensemble indicates systematic temperature and precipitation biases, which are linked to different physical mechanisms in the summer and winter seasons. Overestimation of total cloud cover and underestimation of downward shortwave radiation at the surface, mostly linked to the Grell?Devenyi convection and CAM (Community Atmosphere Model) radiation schemes, intensifies the negative bias in summer temperatures over northern Europe (max ?2.5 °C). Conversely, a strong positive bias in downward shortwave radiation in summer over central (40?60%) and southern Europe mitigates the systematic cold bias over these regions, signifying a typical case of error compensation. Maximum winter cold biases are over northeastern Europe (?2.8 °C); this location suggests that land?atmosphere rather than cloud?radiation interactions are to blame. Precipitation is overestimated in summer by all model configurations, especially the higher quantiles which are associated with summertime deep cumulus convection. The largest precipitation biases are produced by the Kain?Fritsch convection scheme over the Mediterranean. Precipitation biases in winter are lower than those for summer in all model configurations (15?30%). The results of this study indicate the importance of evaluating not only the basic climatic parameters of interest for climate change applications (temperature and precipitation), but also other components of the energy and water cycle, in order to identify the sources of systematic biases, possible compensatory or masking mechanisms and suggest pathways for model improvement.The contribution from Universidad de Cantabria was funded by the Spanish R&D programme through projects CORWES (CGL2010-22158-C02-01) and WRF4G (CGL2011-28864), co-funded by the European Regional Development Fund. M. García-Díez acknowledges financial support from the EXTREMBLES (CGL2010-21869) project

Future Heat Waves in Different European Capitals Based on Climate Change Indicators

Changes in the frequency and intensity of heat waves have shown substantial negative impacts on public health. At the same time, climate change towards increasing air temperatures throughout Europe will foster such extreme events, leading to the population being more exposed to them and societies becoming more vulnerable. Based on two climate change scenarios (Representative Concentration Pathway 4.5 and 8.5) we analysed the frequency and intensity of heat waves for three capital cities in Europe representing a North–South transect (London, Luxembourg, Rome). We used indices proposed by the Expert Team on Sector-Specific Climate Indices of the World Meteorological Organization to analyze the number of heat waves, the number of days that contribute to heat waves, the length of the longest heat waves, as well as the mean temperature during heat waves. The threshold for the definition of heat waves is calculated based on a reference period of 30 years for each of the three cities, allowing for a direct comparison of the projected changes between the cities. Changes in the projected air temperature between a reference period (1971–2000) and three future periods (2001–2030 near future, 2031–2060 middle future, and 2061–2090 far future) are statistically significant for all three cities and both emission scenarios. Considerable similarities could be identified for the different heat wave indices. This directly affects the risk of the exposed population and might also negatively influence food security and water supply