What Price a “Cheap Idea”? Money, Sanctuary, and Its Intertexts

Temple Drake enters Sanctuary at a run; indeed, at one point Faulkner describes her as almost, “running out of her body.” Even when horribly constrained to be still, in barn and brothel, she obeys the imperatives of a particular form of motion, that of circulation in a monetary sense. Temple compulsively circulates throughout Sanctuary, even as that to which she is subjected ensures the successful circulation of the novel

A Volcano-Plutonic Association in Northeastern New South Wales

In the Emmaville-Tenterfield region of northeastern New South Wales, Late Permian comagmatic volcanic and high-level intrusive rocks are spatially associated with large cauldron structures. Major economic concentrations of cassiterite, molybdenite and wolframite are associated with specific leucogranitoid plutons which were intruded to subvolcanic levels in regions between discrete cauldrons. Chemical, mineralogical and field data, used to relate the associated calc-alkaline volcanic and intrusi ve rocks and the various types of mineralization, have led to the recognition of a volcano-plutonic association displaying features common to volcanoplutonic associations developed in evolved geosynclinal environments in many other parts of the world. Igneous activity in the Emmaville-Tenterfield region commenced with the accumulation of large volumes of leucoadamellite and adamellite magma generated by minimum and non-minimum progressi ve partial melting of lower crustal rocks of presumed adamellitic composition. Intrusion of these magmas to high levels within Early Permian silicified siltstones and sandstones induced doming and fracturing of the brittle sedimentary rocks above specific magma chambers, leading to the upward venting of magmas along arcuate fractures and eventual eruption in the form of pyroclastic volcanism. The Emmaville Volcanics so formed, consist of a large number of individual ash flows, minor lava flows and rare ash-fall units which comprise a thick sequence of dominantly rhyolitic volcanics ranging in composition from dacite to high-silica rhyolite. Rare andesites and associated mafic rhyodacites are also present and constitute a geochemically distinct group apparently unrelated to the bulk of the Emmaville Volcanics. The evacuation of large volumes of magma from the high-level chambers caused subsidence of the overlying sedimentary and fresh volcanic rocks, forming simple cauldrons of the Glencoe type

Chemical and Sensory Profiles of Sauvignon Blanc Wine Following Protein Stabilization Using a Combined Ultrafiltration/Heat/Protease Treatment

Ultrafiltration (UF) was evaluated as a process by which proteins can be selectively removed from white wine as an alternative approach to protein stabilization than traditional bentonite fining. Unfined Sauvignon Blanc wine (50 L) was fractionated by UF and the retentate stabilized either by heat and/or protease treatment or bentonite fining before being recombined with the permeate. The heat stability of recombined wine was significantly improved when retentate was heated following protease (Aspergillopepsin) addition and subsequently stabilized by bentonite treatment. The combined UF/heat/protease treatment removed 59% of protein and reduced the quantity of bentonite needed to achieve protein stability by 72%, relative to bentonite treatment alone. This innovative approach to protein stabilization had no significant impact on wine quality or sensory characteristics, affording industry greater confidence in adopting this technology as a novel approach to achieving protein stability.Yihe Sui, David Wollan, Jacqui M. McRae, Richard Muhlack, Dimitra L. Capone, Peter Godden, and Kerry L. Wilkinso

Recent structural insights into the function of copper nitrite reductases.

Copper nitrite reductases (CuNiR) carry out the first committed step of the denitrification pathway of the global nitrogen cycle, the reduction of nitrite (NO2(-)) to nitric oxide (NO). As such, they are of major agronomic and environmental importance. CuNiRs occur primarily in denitrifying soil bacteria which carry out the overall reduction of nitrate to dinitrogen. In this article, we review the insights gained into copper nitrite reductase (CuNiR) function from three dimensional structures. We particularly focus on developments over the last decade, including insights from serial femtosecond crystallography using X-ray free electron lasers (XFELs) and from the recently discovered 3-domain CuNiRs

Implementation of corticosteroids in treating COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK:prospective observational cohort study

BACKGROUND: Dexamethasone was the first intervention proven to reduce mortality in patients with COVID-19 being treated in hospital. We aimed to evaluate the adoption of corticosteroids in the treatment of COVID-19 in the UK after the RECOVERY trial publication on June 16, 2020, and to identify discrepancies in care. METHODS: We did an audit of clinical implementation of corticosteroids in a prospective, observational, cohort study in 237 UK acute care hospitals between March 16, 2020, and April 14, 2021, restricted to patients aged 18 years or older with proven or high likelihood of COVID-19, who received supplementary oxygen. The primary outcome was administration of dexamethasone, prednisolone, hydrocortisone, or methylprednisolone. This study is registered with ISRCTN, ISRCTN66726260. FINDINGS: Between June 17, 2020, and April 14, 2021, 47 795 (75·2%) of 63 525 of patients on supplementary oxygen received corticosteroids, higher among patients requiring critical care than in those who received ward care (11 185 [86·6%] of 12 909 vs 36 415 [72·4%] of 50 278). Patients 50 years or older were significantly less likely to receive corticosteroids than those younger than 50 years (adjusted odds ratio 0·79 [95% CI 0·70–0·89], p=0·0001, for 70–79 years; 0·52 [0·46–0·58], p80 years), independent of patient demographics and illness severity. 84 (54·2%) of 155 pregnant women received corticosteroids. Rates of corticosteroid administration increased from 27·5% in the week before June 16, 2020, to 75–80% in January, 2021. INTERPRETATION: Implementation of corticosteroids into clinical practice in the UK for patients with COVID-19 has been successful, but not universal. Patients older than 70 years, independent of illness severity, chronic neurological disease, and dementia, were less likely to receive corticosteroids than those who were younger, as were pregnant women. This could reflect appropriate clinical decision making, but the possibility of inequitable access to life-saving care should be considered. FUNDING: UK National Institute for Health Research and UK Medical Research Council

Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission

Abstract Admission procalcitonin measurements and microbiology results were available for 1040 hospitalized adults with coronavirus disease 2019 (from 48 902 included in the International Severe Acute Respiratory and Emerging Infections Consortium World Health Organization Clinical Characterisation Protocol UK study). Although procalcitonin was higher in bacterial coinfection, this was neither clinically significant (median [IQR], 0.33 [0.11–1.70] ng/mL vs 0.24 [0.10–0.90] ng/mL) nor diagnostically useful (area under the receiver operating characteristic curve, 0.56 [95% confidence interval, .51–.60]).</jats:p

Global wealth disparities drive adherence to COVID-safe pathways in head and neck cancer surgery

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