Enduring Bonds: Duration and Contact in Close Relationships in Late Life.

BACKGROUND AND OBJECTIVES: Older adults maintain ties to long-duration social partners, some with whom have regular contact and some with whom have little contact. We asked whether these ties with little contact still offer a sense of connection and security, and buffer the effects of interpersonal stress in daily life. Helping older adults foster these ties may improve their mental health. RESEARCH DESIGN AND METHODS: Participants (n = 313) aged 65+ completed a baseline interview reporting duration and contact frequency of their closest ties. Then, participants completed ecological momentary assessments every 3 hr for 5-6 days, reporting their social encounters and mood. RESULTS: We classified ties according to duration (10+ years = long vs shorter duration) and frequency of contact (at least once a month = active vs dormant). Throughout the day, participants were more likely to have stressful encounters with long-duration active ties. Encounters with active ties were associated with more positive mood (regardless of duration) and encounters with long-duration dormant ties with more negative mood. Having more active ties buffered effects of interpersonal stress on mood, but more long-duration dormant ties exacerbated these effects. DISCUSSION AND IMPLICATIONS: Supporting social integration theory, ties with frequent contact were associated with positive mood. Surprisingly, long-duration ties with infrequent contact exacerbated effects of interpersonal stress on mood. Older adults who lack contact with long-duration social partners may be more sensitive to interpersonal stress. Future interventions might focus on phone or electronic media to increase contact with long-duration social partners

Conscientiousness, Career Success, and Longevity: A Lifespan Analysis

Markers of executive functioning, such as prudent planning for the future and impulse control, are related to conscientiousness and may be central to both occupational success and health outcomes. The aim of the study was to examine relations among conscientiousness, career success, and mortality risk across a 65-year period. Using data derived from 693 male participants in the Terman Life Cycle Study, we examined associations among childhood personality, midlife objective career success, and lifelong mortality risk through 2006. Conscientiousness and career success each predicted lower mortality risk (N = 693, relative hazard (rh) = 0.82 [95% confidence interval = 0.74, 0.91] and rh = 0.80 [0.71, 0.91], respectively), with both shared and unique variance. Importantly, childhood personality moderated the success–longevity link; conscientiousness was most relevant for least successful individuals. Conscientiousness and career success predicted longevity, but not in a straightforward manner. Findings highlight the importance of lifespan processes

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types

A first update on mapping the human genetic architecture of COVID-19

peer reviewe

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Coping with a negative social interaction: the role of age and depressive symptoms

Interpersonal stressors, such as arguments and disagreements, are among the most distressing types of daily experiences. It is therefore important to understand how people cope with such stressors. Previous studies suggest that older adults are more likely to use emotion-focused, avoidant, and passive coping strategies during interpersonal tensions (e.g., Birditt & Fingerman, 2003), which are among the most effective strategies for these types of stressors (e.g., Blanchard-Fields et al., 2007). Individuals with greater depressive symptoms also tend to use similar coping strategies and yet, they often exhibit lower efficacy (Coyne, Aldwin, & Lazarus, 1981). The current study investigates how age correlates with depressive symptoms and coping styles in response to a controlled negative interpersonal stressor. Younger adult (18-35 years old) and older adult (60+ years old) participants (N = 159) discussed hypothetical dilemmas with an age-group, gender, and cultural group matched confederate who was scripted to act unfriendly and disagreeable. As expected, individuals with greater depressive symptoms were less likely to engage in active coping and more likely to self-blame, use behavioral disengagement, and be in denial about the negative social interaction with the confederate. Moreover, there was an interaction effect such that with increasing depressive symptoms, older adults were less likely to vent (i.e., express negative affect) with the confederate whereas for younger adults, greater depressive symptoms was associated with greater venting. However, it was also found that depressive symptoms were more likely to be found in the young adult participants than the older adult participants. These findings suggest the importance of considering how the association between depressive symptoms and coping strategies may depend on age and other possible motivational factors

Age differences in affective and cardiovascular responses to a negative social interaction: The role of goals, appraisals, and emotion regulation.

Older adults often report less affective reactivity to interpersonal tensions than younger individuals, but few studies have directly investigated mechanisms explaining this effect. The current study examined whether older adults’ differential endorsement of goals, appraisals, and emotion regulation strategies (i.e., conflict avoidance/de-escalation, self-distraction) during a controlled negative social interaction may explain age differences in affective and cardiovascular responses to the conflict discussion. Participants (N=159; 80 younger adults, 79 older adults) discussed hypothetical dilemmas with disagreeable confederates. Throughout the laboratory session, participants’ subjective emotional experience, blood pressure, and pulse rate were assessed. Older adults generally exhibited less reactivity (negative affect reactivity, diastolic blood pressure reactivity, and pulse rate reactivity) to the task, and more pronounced positive and negative affect recovery following the task, than did younger adults. Older adults appraised the task as more enjoyable and the confederate as more likeable, and more strongly endorsed goals to perform well on the task, which mediated age differences in negative affect reactivity, pulse rate reactivity, and positive affect recovery (i.e., increases in post-task positive affect), respectively. In addition, younger adults showed increased negative affect reactivity with greater use of self-distraction, whereas older adults did not. Together, findings suggest that older adults respond less negatively to unpleasant social interactions than younger adults, and these responses are explained in part by older adults’ pursuit of different motivational goals, less threatening appraisals of the social interaction, and more effective use of self-distraction, compared to younger adults

Cultural differences in coping with interpersonal tensions lead to divergent shorter- and longer-term affective consequences.

Culture influences how people cope with interpersonal tensions, with those from more collectivistic contexts (e.g. Chinese Americans (CA)) generally opting for strategies promoting social harmony whereas those from more individualistic contexts (e.g. European Americans (EA)) preferring confrontational strategies. The current study examined cultural differences in coping strategy choices and their linkages to immediate affective reactions and subsequent affective memories. Participants (N = 159) discussed hypothetical dilemmas with a disagreeable confederate matched by age group, gender, and cultural group. CA exhibited less positive affect reactivity (i.e. smaller decreases in positive affect) and greater positive affect recovery (i.e. greater increases in post-task positive affect) compared to EA, which was explained by CAs appraisals of greater emotional support from the confederate and lower endorsement of defending ones opinions. In contrast, one week later, EA, but not CA, recalled experiencing more task positive affect and less task negative affect than originally reported. Cultural differences in negative affect memory discrepancies were explained by EAs greater tendency to defend their opinions, relative to CA. Culture shapes coping choices, which predict affective consequences over different time scales