A Drosophila-centric view of protein tyrosine phosphatases

AbstractMost of our knowledge on protein tyrosine phosphatases (PTPs) is derived from human pathologies and mouse knockout models. These models largely correlate well with human disease phenotypes, but can be ambiguous due to compensatory mechanisms introduced by paralogous genes. Here we present the analysis of the PTP complement of the fruit fly and the complementary view that PTP studies in Drosophila will accelerate our understanding of PTPs in physiological and pathological conditions. With only 44 PTP genes, Drosophila represents a streamlined version of the human complement. Our integrated analysis places the Drosophila PTPs into evolutionary and functional contexts, thereby providing a platform for the exploitation of the fly for PTP research and the transfer of knowledge onto other model systems

Face-to-Face with the Past: Reconstructing a Teenage Boy from Early Dilmun

Since 2008, the Dilmun Bioarchaeology Project has analyzed the human skeletal remains and artifacts that Peter B. Cornwall excavated from Bahrain in the 1940s, now held in the Hearst Museum of Anthropology. One mode of interpretation and dissemination pursued by the DBP team is forensic facial reconstruction. The subject of the first reconstruction is a twelve- to fifteen-year-old male who lived during the Early Dilmun period (ca. 2050–1800 b.c.e.). The resulting sculpture incorporates skeletal data about his identity and health as well as visual cues grounded in archaeological and sociohistorical contexts. It will be one of two reconstructions at the center of a traveling museum exhibition beginning in 2013. The goal of the exhibition is to present members of past societies to the interested public in a tangible fashion that encourages empathy and an appreciation of our shared humanity

Face-to-Face with the Past: Reconstructing a Teenage Boy from Early Dilmun

Since 2008, the Dilmun Bioarchaeology Project has analyzed the human skeletal remains and artifacts that Peter B. Cornwall excavated from Bahrain in the 1940s, now held in the Hearst Museum of Anthropology. One mode of interpretation and dissemination pursued by the DBP team is forensic facial reconstruction. The subject of the first reconstruction is a twelve- to fifteen-year-old male who lived during the Early Dilmun period (ca. 2050–1800 b.c.e.). The resulting sculpture incorporates skeletal data about his identity and health as well as visual cues grounded in archaeological and sociohistorical contexts. It will be one of two reconstructions at the center of a traveling museum exhibition beginning in 2013. The goal of the exhibition is to present members of past societies to the interested public in a tangible fashion that encourages empathy and an appreciation of our shared humanity