Androgen-independent events in penile development in humans and animals.

The common view on penile development is that it is androgen-dependent, based first and foremost on the fact that the genital tubercle forms a penis in males and a clitoris in females. However, critical examination of the complex processes involved in human penile development reveals that many individual steps in development of the genital tubercle are common to both males and females, and thus can be interpreted as androgen-independent. For certain developmental events this conclusion is bolstered by observations in androgen-insensitive patients and androgen receptor mutant mice. Events in genital tubercle development that are common to human males and females include: formation of (a) the genital tubercle, (b) the urethral plate, (c) the urethral groove, (d) the glans, (e) the prepuce and (f) the corporal body. For humans 6 of 13 individual developmental steps in penile development were interpreted as androgen-independent. For mice 5 of 11 individual developmental steps were found to be androgen-independent, which were verified through analysis of androgen-insensitive mutants. Observations from development of external genitalia of other species (moles and spotted hyena) provide further examples of androgen-independent events in penile development. These observations support the counter-intuitive idea that penile development involves both androgen-independent and androgen-dependent processes

Statistics of football dynamics

We investigate the dynamics of football matches. Our goal is to characterize statistically the temporal sequence of ball movements in this collective sport game, searching for traits of complex behavior. Data were collected over a variety of matches in South American, European and World championships throughout 2005 and 2006. We show that the statistics of ball touches presents power-law tails and can be described by $q$-gamma distributions. To explain such behavior we propose a model that provides information on the characteristics of football dynamics. Furthermore, we discuss the statistics of duration of out-of-play intervals, not directly related to the previous scenario.Comment: 7 page

Emergence of a measurement basis in atom-photon scattering

The process of quantum measurement has been a long standing source of debate. A measurement is postulated to collapse a wavefunction onto one of the states of a predetermined set - the measurement basis. This basis origin is not specified within quantum mechanics. According to the theory of decohernce, a measurement basis is singled out by the nature of coupling of a quantum system to its environment. Here we show how a measurement basis emerges in the evolution of the electronic spin of a single trapped atomic ion due to spontaneous photon scattering. Using quantum process tomography we visualize the projection of all spin directions, onto this basis, as a photon is scattered. These basis spin states are found to be aligned with the scattered photon propagation direction. In accordance with decohernce theory, they are subjected to a minimal increase in entropy due to the photon scattering, while, orthogonal states become fully mixed and their entropy is maximally increased. Moreover, we show that detection of the scattered photon polarization measures the spin state of the ion, in the emerging basis, with high fidelity. Lastly, we show that while photon scattering entangles all superpositions of pointer states with the scattered photon polarization, the measurement-basis states themselves remain classically correlated with it. Our findings show that photon scattering by atomic spin superpositions fulfils all the requirements from a quantum measurement process

Dynamic Bradley–Terry modelling of sports tournaments

Summary.  In the course of national sports tournaments, usually lasting several months, it is expected that the abilities of teams taking part in the tournament will change over time. A dynamic extension of the Bradley–Terry model for paired comparison data is introduced to model the outcomes of sporting contests, allowing for time varying abilities. It is assumed that teams’ home and away abilities depend on past results through exponentially weighted moving average processes. The model proposed is applied to sports data with and without tied contests, namely the 2009–2010 regular season of the National Basketball Association tournament and the 2008–2009 Italian Serie A football season

High-fidelity state detection and tomography of a single ion Zeeman qubit

We demonstrate high-fidelity Zeeman qubit state detection in a single trapped 88 Sr+ ion. Qubit readout is performed by shelving one of the qubit states to a metastable level using a narrow linewidth diode laser at 674 nm followed by state-selective fluorescence detection. The average fidelity reached for the readout of the qubit state is 0.9989(1). We then measure the fidelity of state tomography, averaged over all possible single-qubit states, which is 0.9979(2). We also fully characterize the detection process using quantum process tomography. This readout fidelity is compatible with recent estimates of the detection error-threshold required for fault-tolerant computation, whereas high-fidelity state tomography opens the way for high-precision quantum process tomography

A Woman’s Portion: 5000 Years a Slave

Slavery has existed for all of recorded history. The evidence is conclusive that slave systems have almost always been majority female. I suggest that slavery originated as an attempt to control female reproductive capacity, and that this attempt to control was not limited to enslaved women

A core genetic module : the Mixed Feedback Loop

The so-called Mixed Feedback Loop (MFL) is a small two-gene network where protein A regulates the transcription of protein B and the two proteins form a heterodimer. It has been found to be statistically over-represented in statistical analyses of gene and protein interaction databases and to lie at the core of several computer-generated genetic networks. Here, we propose and mathematically study a model of the MFL and show that, by itself, it can serve both as a bistable switch and as a clock (an oscillator) depending on kinetic parameters. The MFL phase diagram as well as a detailed description of the nonlinear oscillation regime are presented and some biological examples are discussed. The results emphasize the role of protein interactions in the function of genetic modules and the usefulness of modelling RNA dynamics explicitly.Comment: To be published in Physical Review

The Effect of Psychomotor Performance, Cerebral and Arterial Blood Saturation Between African-American and Caucasian Males Before, During and After Normobaric Hypoxic Exercise

International Journal of Exercise Science 10(5): 655-665, 2017. To further elucidate physiological and cognitive performance differences between African-American (AA) and Caucasian individuals (CAU) before, during or after hypoxic and normoxic exercise. Twelve college aged (18-25) apparently healthy African-American (six volunteers) and Caucasian (six subjects) males took part in two trials consisting of normobaric normoxia and normobaric hypoxia (12% oxygen). Each subject cycled at 50% of their altitude adjusted VO2max (-26% of normoxia VO2max) for one hour after a two-hour baseline. Subjects were monitored for cerebral and arterial O2 saturation, as well as the Trail Making Test A and B (TMT) psychomotor performance. Arterial saturation proved to be significantly higher in AA (86.0±4.7) compared to CAU (79.5±4.8) during the first 60 minutes of exposure to hypoxia at rest (p=0.039), but not during exercise. However, cerebral oxygenation to the left frontal lobe was decreased near the conclusion and in 30 minutes after normoxic exercise. TMT B data revealed that CAU (79±12.7) had faster scores than the AA subjects (98±25.1) at all time points and was significantly different at the 115-minute time point of the hypoxic trial (p=0.024). The data suggests that before, during and after normobaric normoxia and hypoxia trial there is a differential response between AA and CAU in regards to arterial and cerebral oxygenation, as well as psychomotor tests