Socialismo e Liberdade : o PSB e a cultura socialista-democrática no Brasil (1945-1965)

Dissertação (mestrado)—Universidade de Brasília, Instituto de Ciências Humanas, Programa de Pós-Graduação em História, 2014.O Partido Socialista Brasileiro (PSB) é objeto de pesquisa desta dissertação de mestrado. Os enfoques deste trabalho estão situados na análise da formação do PSB, partido político surgido no processo de redemocratização brasileira de 1945, por meio da ação de variados atores com experiências e ideias políticas que, embora estivessem todas no campo ideológico da esquerda, eram substantivamente distintas do pensamento de esquerda, mais ortodoxo, em especial o marxismo stalinista do PCB. Este trabalho também consiste em analisar os elementos peculiares que caracterizaram o projeto socialista democrático do PSB, que combinava igualdade social com liberdades civis e políticas. Enfatiza-se na análise as modificações sofridas pelo projeto e pelo discurso do PSB, que são visíveis a partir da década de 1950. Por fim, analisa-se a história do partido no período entre 1945-1965. Debruçamo-nos sobre a experiência e sobre o percurso do socialismo democrático no Brasil por meio das ações do partido em todo esse período democrático. _______________________________________________________________________________________ ABSTRACTThe Brazilian Socialist Party (PSB) is the research object of this dissertation. The approaches that work are situated in analyzing formation of the PSB, political party, emerged in the 1945 Brazilian democratization process, through the action of actors with varying experiences and political views, even though they were all on the ideological left field, were substantively distinct from left thinking, more orthodox , especially the Stalinist Marxism of the PCB. This work also consists of analyzing the peculiar elements that characterized the democratic socialist project of the PSB, which combined social equality with civil and political liberties. We emphasize the analysis the changes undergone by the project and by the discourse of the PSB that are visible from the 1950s. Finally, we analyze the history of the party in the period 1945 to 1965. We focused on the experience and on the path of democratic socialism in Brazil through the actions of the party in all this democratic period

A genetic algorithm based determination of the ground and excited ( 1 L b ) state structure and the orientation of the transition dipole moment of benzimidazolew

The structure of benzimidazole has been determined in the electronic ground and excited states using rotationally resolved electronic spectroscopy. The rovibronic spectra of four isotopomers and subsequently the structure of benzimidazole have been automatically assigned and fitted using a genetic algorithm based fitting strategy. The lifetimes of the deuterated isotopomers have been shown to depend on the position of deuteration. The angle of the transition dipole moment with the inertial a-axis could be determined to be À301. Structures and transition dipole moment orientation have been calculated at various levels of theory and were compared to the experimental results

Identification of the anti-mycobacterial functional properties of piperidinol derivatives

BACKGROUND AND PURPOSE: Tuberculosis (TB) remains a major global health threat and is now the leading cause of death from a single infectious agent worldwide. The current TB drug regimen is inadequate, and new anti-tubercular agents are urgently required to be able to successfully combat the increasing prevalence of drug-resistant TB. The purpose of this study was to investigate a piperidinol compound derivative that is highly active against the Mycobacterium tuberculosis bacillus. EXPERIMENTAL APPROACH: The antibacterial properties of the piperidinol compound and its corresponding bis-Mannich base analogue were evaluated against M. smegmatis and Gram-negative organisms. Cytotoxicity studies were undertaken in order to determine the selectivity index for these compounds. Spontaneous resistant mutants of M. smegmatis were generated against the piperidinol and corresponding bis-Mannich base lead derivatives and whole genome sequencing employed to determine the genetic modifications that lead to selection pressure in the presence of these compounds. KEY RESULTS: The piperidinol and the bis-Mannich base analogue were found to be selective for mycobacteria and rapidly kill this organism with a cytotoxicity selectivity index for mycobacteria of >30-fold. Whole genome sequencing of M. smegmatis strains resistant to the lead compounds led to the identification of a number of single nucleotide polymorphisms indicating multiple targets. CONCLUSION AND IMPLICATIONS: Our results indicate that the piperidinol moiety represents an attractive compound class in the pursuit of novel anti-tubercular agents. LINKED ARTICLES: This article is part of a themed section on Drug Metabolism and Antibiotic Resistance in Micro-organisms. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.14/issuetoc

Risk factors associated with default from multi- and extensively drug-resistant tuberculosis treatment, uzbekistan: a retrospective cohort analysis.

The Médecins Sans Frontières project of Uzbekistan has provided multidrug-resistant tuberculosis treatment in the Karakalpakstan region since 2003. Rates of default from treatment have been high, despite psychosocial support, increasing particularly since programme scale-up in 2007. We aimed to determine factors associated with default in multi- and extensively drug-resistant tuberculosis patients who started treatment between 2003 and 2008 and thus had finished approximately 2 years of treatment by the end of 2010

Rapid Diagnosis of Tuberculosis with the Xpert MTB/RIF Assay in High Burden Countries: A Cost-Effectiveness Analysis

A cost-effectiveness study by Frank Cobelens and colleagues reveals that Xpert MTB/RIF is a cost-effective method of tuberculosis diagnosis that is suitable for use in low- and middle-income settings

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis

New therapeutic strategies are needed to combat the tuberculosis pandemic and the spread of multidrug-resistant (MDR) and extensively drug-resistant (XDR) forms of the disease, which remain a serious public health challenge worldwide1, 2. The most urgent clinical need is to discover potent agents capable of reducing the duration of MDR and XDR tuberculosis therapy with a success rate comparable to that of current therapies for drug-susceptible tuberculosis. The last decade has seen the discovery of new agent classes for the management of tuberculosis3, 4, 5, several of which are currently in clinical trials6, 7, 8. However, given the high attrition rate of drug candidates during clinical development and the emergence of drug resistance, the discovery of additional clinical candidates is clearly needed. Here, we report on a promising class of imidazopyridine amide (IPA) compounds that block Mycobacterium tuberculosis growth by targeting the respiratory cytochrome bc1 complex. The optimized IPA compound Q203 inhibited the growth of MDR and XDR M. tuberculosis clinical isolates in culture broth medium in the low nanomolar range and was efficacious in a mouse model of tuberculosis at a dose less than 1 mg per kg body weight, which highlights the potency of this compound. In addition, Q203 displays pharmacokinetic and safety profiles compatible with once-daily dosing. Together, our data indicate that Q203 is a promising new clinical candidate for the treatment of tuberculosis